Literature DB >> 27590333

MicroRNA-Mediated Post-Transcriptional Regulation of Epithelial to Mesenchymal Transition in Cancer.

Golnoush Dehbashi Behbahani1, Nastaran Mohammadi Ghahhari2, Mohammad Amin Javidi1, Asghar Farzi Molan1, Neda Feizi3, Sadegh Babashah4.   

Abstract

Epithelial to mesenchymal transition (EMT) program participates in tissue repair, embryogenesis and numerous pathological conditions, particularly cancer progression and tumor metastasis. A highly complex and strongly controlled post-transcriptionally regulated network of microRNAs (miRNAs) regulates the EMT process. miRNAs are critical parts of the post-transcriptional regulation of gene expression. A set of miRNAs target multiple components of major signaling pathways and downstream effectors of EMT. miRNAs associated with this process are involved in controlling tumor progression and invasiveness either as oncogenes or as tumor suppressors. Since several miRNAs directly affect EMT-related master regulators, they have been discovered to have the potential to be used as biomarkers or targets in EMT-based pathological conditions such as cancer. Therefore, comprehensive understanding of miRNA-EMT correlation with tumor metastatic spread may provide improvements to diagnostic tools or therapeutics for cancer. This review summarizes our current knowledge about some of these important miRNAs and focuses on their specific roles in regulation of the EMT process in cancer.

Entities:  

Keywords:  Cancer; Epithelial to mesenchymal transition; Post-transcriptional regulation; microRNAs

Mesh：

Substances：

Year:  2016        PMID： 27590333     DOI： 10.1007/s12253-016-0101-6

Source DB:  PubMed          Journal:  Pathol Oncol Res        ISSN： 1219-4956            Impact factor:   3.201


  128 in total

1.  MicroRNA-30a inhibits epithelial-to-mesenchymal transition by targeting Snai1 and is downregulated in non-small cell lung cancer.

Authors:  Regalla Kumarswamy; Giridhar Mudduluru; Paolo Ceppi; Santoshi Muppala; Miroslaw Kozlowski; Jacek Niklinski; Mauro Papotti; Heike Allgayer
Journal:  Int J Cancer       Date:  2011-08-08       Impact factor: 7.396

2.  Growth-suppressive function of phosphatidylethanolamine-binding protein in anaplastic thyroid cancer.

Authors:  Junko Akaishi; Masamitsu Onda; Shinichi Asaka; Junichi Okamoto; Shizuyo Miyamoto; Mitsuji Nagahama; Kouichi Ito; Oichi Kawanami; Kazuo Shimizu
Journal:  Anticancer Res       Date:  2006 Nov-Dec       Impact factor: 2.480

Review 3.  Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

Authors:  Héctor Peinado; David Olmeda; Amparo Cano
Journal:  Nat Rev Cancer       Date:  2007-05-17       Impact factor: 60.716

Review 4.  Regulatory networks defining EMT during cancer initiation and progression.

Authors:  Bram De Craene; Geert Berx
Journal:  Nat Rev Cancer       Date:  2013-02       Impact factor: 60.716

5.  Expression of twist and wnt in human breast cancer.

Authors:  Osamu Watanabe; Hiroshi Imamura; Tadao Shimizu; Jun Kinoshita; Toshihiro Okabe; Akira Hirano; Kazuhiko Yoshimatsu; Soichi Konno; Motohiko Aiba; Kenji Ogawa
Journal:  Anticancer Res       Date:  2004 Nov-Dec       Impact factor: 2.480

6.  The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma.

Authors:  Brian C Lewis; David S Klimstra; Nicholas D Socci; Su Xu; Jason A Koutcher; Harold E Varmus
Journal:  Mol Cell Biol       Date:  2005-02       Impact factor: 4.272

7.  Unique microRNA molecular profiles in lung cancer diagnosis and prognosis.

Authors:  Nozomu Yanaihara; Natasha Caplen; Elise Bowman; Masahiro Seike; Kensuke Kumamoto; Ming Yi; Robert M Stephens; Aikou Okamoto; Jun Yokota; Tadao Tanaka; George Adrian Calin; Chang-Gong Liu; Carlo M Croce; Curtis C Harris
Journal:  Cancer Cell       Date:  2006-03       Impact factor: 31.743

8.  Clinical significance of high mobility group A2 in human gastric cancer and its relationship to let-7 microRNA family.

Authors:  Kazuo Motoyama; Hiroshi Inoue; Yoshito Nakamura; Hiroyuki Uetake; Kenichi Sugihara; Masaki Mori
Journal:  Clin Cancer Res       Date:  2008-04-15       Impact factor: 12.531

9.  Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization.

Authors:  Manav Korpal; Brian J Ell; Francesca M Buffa; Toni Ibrahim; Mario A Blanco; Toni Celià-Terrassa; Laura Mercatali; Zia Khan; Hani Goodarzi; Yuling Hua; Yong Wei; Guohong Hu; Benjamin A Garcia; Jiannis Ragoussis; Dino Amadori; Adrian L Harris; Yibin Kang
Journal:  Nat Med       Date:  2011-08-07       Impact factor: 53.440

10.  MicroRNA-200 family modulation in distinct breast cancer phenotypes.

Authors:  María Ángeles Castilla; Juan Díaz-Martín; David Sarrió; Laura Romero-Pérez; María Ángeles López-García; Begoña Vieites; Michele Biscuola; Susana Ramiro-Fuentes; Clare M Isacke; José Palacios
Journal:  PLoS One       Date:  2012-10-24       Impact factor: 3.240
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  16 in total

1.  MiR-98 inhibits malignant progression via targeting MTDH in squamous cell carcinoma of the head and neck.

Authors:  Haolei Tan; Gangcai Zhu; Li She; Ming Wei; Yunyun Wang; Leiming Pi; Changhan Chen; Diekuo Zhang; Pingqing Tan; Jie Chen; Donghai Huang; Yongquan Tian; Yong Liu; Xin Zhang
Journal:  Am J Cancer Res       Date:  2017-12-01       Impact factor: 6.166

Review 2.  The Kraken Wakes: induced EMT as a driver of tumour aggression and poor outcome.

Authors:  Andrew D Redfern; Lisa J Spalding; Erik W Thompson
Journal:  Clin Exp Metastasis       Date:  2018-06-08       Impact factor: 5.150

3.  Identification of potential tumor-educated platelets RNA biomarkers in non-small-cell lung cancer by integrated bioinformatical analysis.

Authors:  Linlin Xue; Li Xie; Xingguo Song; Xianrang Song
Journal:  J Clin Lab Anal       Date:  2018-04-17       Impact factor: 2.352

Review 4.  Advances of exosome isolation techniques in lung cancer.

Authors:  Elham O Mahgoub; Ehsan Razmara; Amirreza Bitaraf; Fahimeh-Sadat Norouzi; Maryam Montazeri; Roudabeh Behzadi-Andouhjerdi; Mojtaba Falahati; Ke Cheng; Yousif Haik; Anwarul Hasan; Sadegh Babashah
Journal:  Mol Biol Rep       Date:  2020-08-12       Impact factor: 2.316

Review 5.  Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer.

Authors:  Antoine Legras; Nicolas Pécuchet; Sandrine Imbeaud; Karine Pallier; Audrey Didelot; Hélène Roussel; Laure Gibault; Elizabeth Fabre; Françoise Le Pimpec-Barthes; Pierre Laurent-Puig; Hélène Blons
Journal:  Cancers (Basel)       Date:  2017-08-03       Impact factor: 6.639

Review 6.  More than Just a Simple Cardiac Envelope; Cellular Contributions of the Epicardium.

Authors:  Angel Dueñas; Amelia E Aranega; Diego Franco
Journal:  Front Cell Dev Biol       Date:  2017-05-01

Review 7.  Controversies around epithelial-mesenchymal plasticity in cancer metastasis.

Authors:  Elizabeth D Williams; Dingcheng Gao; Andrew Redfern; Erik W Thompson
Journal:  Nat Rev Cancer       Date:  2019-10-30       Impact factor: 60.716

8.  A qRT-PCR and Gene Functional Enrichment Study Focused on Downregulation of miR-141-3p in Hepatocellular Carcinoma and Its Clinicopathological Significance.

Authors:  Cui-Zhen Liu; Zhi-Hua Ye; Jie Ma; Rong-Quan He; Hai-Wei Liang; Zhi-Gang Peng; Gang Chen
Journal:  Technol Cancer Res Treat       Date:  2017-04-23

9.  MiR-155 Promotes Uveal Melanoma Cell Proliferation and Invasion by Regulating NDFIP1 Expression.

Authors:  Jing Peng; Honglei Liu; Cuihong Liu
Journal:  Technol Cancer Res Treat       Date:  2017-11-01

10.  Silencing Lin28 promotes apoptosis in colorectal cancer cells by upregulating let‑7c targeting of antiapoptotic BCL2L1.

Authors:  Haogang Zhang; Yaguang Zong; Gongcai Qiu; Ruichun Jia; Xunzheng Xu; Fujing Wang; Dequan Wu
Journal:  Mol Med Rep       Date:  2018-01-25       Impact factor: 2.952
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