Literature DB >> 27587788

A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci.

Kristin A Rand1, Chi Song1, Eric Dean2, Daniel J Serie3, Karen Curtin4, Xin Sheng1, Donglei Hu5, Carol Ann Huff6, Leon Bernal-Mizrachi7, Michael H Tomasson8, Sikander Ailawadhi3, Seema Singhal9, Karen Pawlish10, Edward S Peters11, Cathryn H Bock12, Alex Stram13, David J Van Den Berg1, Christopher K Edlund1, David V Conti1, Todd Zimmerman14, Amie E Hwang1, Scott Huntsman5, John Graff15, Ajay Nooka7, Yinfei Kong1, Silvana L Pregja12, Sonja I Berndt16, William J Blot17,18, John Carpten19, Graham Casey1, Lisa Chu20,21, W Ryan Diver22, Victoria L Stevens22, Michael R Lieber1, Phyllis J Goodman23, Anselm J M Hennis24,25, Ann W Hsing21, Jayesh Mehta9, Rick A Kittles26, Suzanne Kolb27, Eric A Klein28, Cristina Leske24, Adam B Murphy9, Barbara Nemesure24, Christine Neslund-Dudas29, Sara S Strom30, Ravi Vij8, Benjamin A Rybicki29, Janet L Stanford27, Lisa B Signorello31, John S Witte32, Christine B Ambrosone33, Parveen Bhatti27, Esther M John20,21, Leslie Bernstein34, Wei Zheng17, Andrew F Olshan35, Jennifer J Hu36, Regina G Ziegler16, Sarah J Nyante35, Elisa V Bandera15, Brenda M Birmann31, Sue A Ingles1, Michael F Press1, Djordje Atanackovic4, Martha J Glenn4, Lisa A Cannon-Albright4, Brandt Jones4, Guido Tricot37, Thomas G Martin5, Shaji K Kumar38, Jeffrey L Wolf5, Sandra L Deming Halverson17, Nathaniel Rothman16, Angela R Brooks-Wilson39, S Vincent Rajkumar38, Laurence N Kolonel40, Stephen J Chanock16, Susan L Slager38, Richard K Severson12, Nalini Janakiraman29, Howard R Terebelo41, Elizabeth E Brown42, Anneclaire J De Roos43, Ann F Mohrbacher1, Graham A Colditz8, Graham G Giles44,45,46, John J Spinelli39,47, Brian C Chiu14, Nikhil C Munshi48, Kenneth C Anderson48, Joan Levy49, Jeffrey A Zonder12, Robert Z Orlowski30, Sagar Lonial7, Nicola J Camp4, Celine M Vachon38, Elad Ziv5, Daniel O Stram1, Dennis J Hazelett50, Christopher A Haiman51, Wendy Cozen51.   

Abstract

BACKGROUND: Genome-wide association studies (GWAS) in European populations have identified genetic risk variants associated with multiple myeloma.
METHODS: We performed association testing of common variation in eight regions in 1,318 patients with multiple myeloma and 1,480 controls of European ancestry and 1,305 patients with multiple myeloma and 7,078 controls of African ancestry and conducted a meta-analysis to localize the signals, with epigenetic annotation used to predict functionality.
RESULTS: We found that variants in 7p15.3, 17p11.2, 22q13.1 were statistically significantly (P < 0.05) associated with multiple myeloma risk in persons of African ancestry and persons of European ancestry, and the variant in 3p22.1 was associated in European ancestry only. In a combined African ancestry-European ancestry meta-analysis, variation in five regions (2p23.3, 3p22.1, 7p15.3, 17p11.2, 22q13.1) was statistically significantly associated with multiple myeloma risk. In 3p22.1, the correlated variants clustered within the gene body of ULK4 Correlated variants in 7p15.3 clustered around an enhancer at the 3' end of the CDCA7L transcription termination site. A missense variant at 17p11.2 (rs34562254, Pro251Leu, OR, 1.32; P = 2.93 × 10-7) in TNFRSF13B encodes a lymphocyte-specific protein in the TNF receptor family that interacts with the NF-κB pathway. SNPs correlated with the index signal in 22q13.1 cluster around the promoter and enhancer regions of CBX7
CONCLUSIONS: We found that reported multiple myeloma susceptibility regions contain risk variants important across populations, supporting the use of multiple racial/ethnic groups with different underlying genetic architecture to enhance the localization and identification of putatively functional alleles. IMPACT: A subset of reported risk loci for multiple myeloma has consistent effects across populations and is likely to be functional. Cancer Epidemiol Biomarkers Prev; 25(12); 1609-18. ©2016 AACR. ©2016 American Association for Cancer Research.

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Year:  2016        PMID: 27587788      PMCID: PMC5524541          DOI: 10.1158/1055-9965.EPI-15-1193

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN: 1055-9965            Impact factor:   4.254


  37 in total

1.  Principal components analysis corrects for stratification in genome-wide association studies.

Authors:  Alkes L Price; Nick J Patterson; Robert M Plenge; Michael E Weinblatt; Nancy A Shadick; David Reich
Journal:  Nat Genet       Date:  2006-07-23       Impact factor: 38.330

2.  The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells.

Authors:  Niels Weinhold; Tobias Meissner; David C Johnson; Anja Seckinger; Jérôme Moreaux; Asta Försti; Bowang Chen; Jolanta Nickel; Daniel Chubb; Andrew C Rawstron; Chi Doughty; Nasrin B Dahir; Dil B Begum; Kwee Young; Brian A Walker; Per Hoffmann; Marcus M Nöthen; Faith E Davies; Bernard Klein; Hartmut Goldschmidt; Gareth J Morgan; Richard S Houlston; Dirk Hose; Kari Hemminki
Journal:  Haematologica       Date:  2014-12-05       Impact factor: 9.941

3.  Genome-wide scan identifies variant in 2q12.3 associated with risk for multiple myeloma.

Authors:  Stephen W Erickson; Vinay R Raj; Owen W Stephens; Ishwori Dhakal; Shweta S Chavan; Naveen Sanathkumar; Elizabeth Ann Coleman; Jeannette Y Lee; Julia A Goodwin; Senu Apewokin; Daohong Zhou; Joshua Epstein; Christoph J Heuck; Annette J Vangsted
Journal:  Blood       Date:  2014-09-18       Impact factor: 22.113

4.  BAFF supports human B cell differentiation in the lymphoid follicles through distinct receptors.

Authors:  Xin Zhang; Chan-Sik Park; Sun-Ok Yoon; Li Li; Yen-Ming Hsu; Christine Ambrose; Yong Sung Choi
Journal:  Int Immunol       Date:  2005-05-20       Impact factor: 4.823

5.  [Downregulation of chromobox protein homolog 7 expression in multiple human cancer tissues].

Authors:  Zhen-Po Guan; Lian-Kun Gu; Bao-Cai Xing; Jia-Fu Ji; Jin Gu; Da-Jun Deng
Journal:  Zhonghua Yu Fang Yi Xue Za Zhi       Date:  2011-07

6.  Risk patterns of multiple myeloma in Los Angeles County, 1972-1999 (United States).

Authors:  Mulugeta Gebregziabher; Leslie Bernstein; Yaping Wang; Wendy Cozen
Journal:  Cancer Causes Control       Date:  2006-09       Impact factor: 2.506

7.  Predicting functional effect of human missense mutations using PolyPhen-2.

Authors:  Ivan Adzhubei; Daniel M Jordan; Shamil R Sunyaev
Journal:  Curr Protoc Hum Genet       Date:  2013-01

8.  FunciSNP: an R/bioconductor tool integrating functional non-coding data sets with genetic association studies to identify candidate regulatory SNPs.

Authors:  Simon G Coetzee; Suhn K Rhie; Benjamin P Berman; Gerhard A Coetzee; Houtan Noushmehr
Journal:  Nucleic Acids Res       Date:  2012-06-08       Impact factor: 16.971

9.  TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation.

Authors:  X Z Xia; J Treanor; G Senaldi; S D Khare; T Boone; M Kelley; L E Theill; A Colombero; I Solovyev; F Lee; S McCabe; R Elliott; K Miner; N Hawkins; J Guo; M Stolina; G Yu; J Wang; J Delaney; S Y Meng; W J Boyle; H Hsu
Journal:  J Exp Med       Date:  2000-07-03       Impact factor: 14.307

10.  The UCSC Genome Browser database: 2014 update.

Authors:  Donna Karolchik; Galt P Barber; Jonathan Casper; Hiram Clawson; Melissa S Cline; Mark Diekhans; Timothy R Dreszer; Pauline A Fujita; Luvina Guruvadoo; Maximilian Haeussler; Rachel A Harte; Steve Heitner; Angie S Hinrichs; Katrina Learned; Brian T Lee; Chin H Li; Brian J Raney; Brooke Rhead; Kate R Rosenbloom; Cricket A Sloan; Matthew L Speir; Ann S Zweig; David Haussler; Robert M Kuhn; W James Kent
Journal:  Nucleic Acids Res       Date:  2013-11-21       Impact factor: 16.971

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  11 in total

Review 1.  Genome-Wide Association Studies of Cancer in Diverse Populations.

Authors:  Sungshim L Park; Iona Cheng; Christopher A Haiman
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2017-06-21       Impact factor: 4.254

2.  A meta-analysis of genome-wide association studies of multiple myeloma among men and women of African ancestry.

Authors:  Zhaohui Du; Niels Weinhold; Gregory Chi Song; Kristin A Rand; David J Van Den Berg; Amie E Hwang; Xin Sheng; Victor Hom; Sikander Ailawadhi; Ajay K Nooka; Seema Singhal; Karen Pawlish; Edward S Peters; Cathryn Bock; Ann Mohrbacher; Alexander Stram; Sonja I Berndt; William J Blot; Graham Casey; Victoria L Stevens; Rick Kittles; Phyllis J Goodman; W Ryan Diver; Anselm Hennis; Barbara Nemesure; Eric A Klein; Benjamin A Rybicki; Janet L Stanford; John S Witte; Lisa Signorello; Esther M John; Leslie Bernstein; Antoinette M Stroup; Owen W Stephens; Maurizio Zangari; Frits Van Rhee; Andrew Olshan; Wei Zheng; Jennifer J Hu; Regina Ziegler; Sarah J Nyante; Sue Ann Ingles; Michael F Press; John David Carpten; Stephen J Chanock; Jayesh Mehta; Graham A Colditz; Jeffrey Wolf; Thomas G Martin; Michael Tomasson; Mark A Fiala; Howard Terebelo; Nalini Janakiraman; Laurence Kolonel; Kenneth C Anderson; Loic Le Marchand; Daniel Auclair; Brian C-H Chiu; Elad Ziv; Daniel Stram; Ravi Vij; Leon Bernal-Mizrachi; Gareth J Morgan; Jeffrey A Zonder; Carol Ann Huff; Sagar Lonial; Robert Z Orlowski; David V Conti; Christopher A Haiman; Wendy Cozen
Journal:  Blood Adv       Date:  2020-01-14

3.  Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma.

Authors:  Xiaomu Wei; M Nieves Calvo-Vidal; Siwei Chen; Gang Wu; Maria V Revuelta; Jian Sun; Jinghui Zhang; Michael F Walsh; Kim E Nichols; Vijai Joseph; Carrie Snyder; Celine M Vachon; James D McKay; Shu-Ping Wang; David S Jayabalan; Lauren M Jacobs; Dina Becirovic; Rosalie G Waller; Mykyta Artomov; Agnes Viale; Jayeshkumar Patel; Jude Phillip; Selina Chen-Kiang; Karen Curtin; Mohamed Salama; Djordje Atanackovic; Ruben Niesvizky; Ola Landgren; Susan L Slager; Lucy A Godley; Jane Churpek; Judy E Garber; Kenneth C Anderson; Mark J Daly; Robert G Roeder; Charles Dumontet; Henry T Lynch; Charles G Mullighan; Nicola J Camp; Kenneth Offit; Robert J Klein; Haiyuan Yu; Leandro Cerchietti; Steven M Lipkin
Journal:  Cancer Res       Date:  2018-03-20       Impact factor: 12.701

4.  Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma.

Authors:  Molly Went; Amit Sud; Asta Försti; Britt-Marie Halvarsson; Niels Weinhold; Scott Kimber; Mark van Duin; Gudmar Thorleifsson; Amy Holroyd; David C Johnson; Ni Li; Giulia Orlando; Philip J Law; Mina Ali; Bowang Chen; Jonathan S Mitchell; Daniel F Gudbjartsson; Rowan Kuiper; Owen W Stephens; Uta Bertsch; Peter Broderick; Chiara Campo; Obul R Bandapalli; Hermann Einsele; Walter A Gregory; Urban Gullberg; Jens Hillengass; Per Hoffmann; Graham H Jackson; Karl-Heinz Jöckel; Ellinor Johnsson; Sigurður Y Kristinsson; Ulf-Henrik Mellqvist; Hareth Nahi; Douglas Easton; Paul Pharoah; Alison Dunning; Julian Peto; Federico Canzian; Anthony Swerdlow; Rosalind A Eeles; ZSofia Kote-Jarai; Kenneth Muir; Nora Pashayan; Jolanta Nickel; Markus M Nöthen; Thorunn Rafnar; Fiona M Ross; Miguel Inacio da Silva Filho; Hauke Thomsen; Ingemar Turesson; Annette Vangsted; Niels Frost Andersen; Anders Waage; Brian A Walker; Anna-Karin Wihlborg; Annemiek Broyl; Faith E Davies; Unnur Thorsteinsdottir; Christian Langer; Markus Hansson; Hartmut Goldschmidt; Martin Kaiser; Pieter Sonneveld; Kari Stefansson; Gareth J Morgan; Kari Hemminki; Björn Nilsson; Richard S Houlston
Journal:  Nat Commun       Date:  2018-09-13       Impact factor: 14.919

Review 5.  Germline Risk Contribution to Genomic Instability in Multiple Myeloma.

Authors:  Siegfried Janz; Fenghuang Zhan; Fumou Sun; Yan Cheng; Michael Pisano; Ye Yang; Hartmut Goldschmidt; Parameswaran Hari
Journal:  Front Genet       Date:  2019-05-08       Impact factor: 4.599

6.  LRP1B Polymorphisms Are Associated with Multiple Myeloma Risk in a Chinese Han Population.

Authors:  Bingjie Li; Chenxi Liu; Guixue Cheng; Mengle Peng; Xiaosong Qin; Yong Liu; Yongzhe Li; Dongchun Qin
Journal:  J Cancer       Date:  2019-01-01       Impact factor: 4.207

Review 7.  Genome Instability in Multiple Myeloma: Facts and Factors.

Authors:  Anna Y Aksenova; Anna S Zhuk; Artem G Lada; Irina V Zotova; Elena I Stepchenkova; Ivan I Kostroma; Sergey V Gritsaev; Youri I Pavlov
Journal:  Cancers (Basel)       Date:  2021-11-26       Impact factor: 6.639

Review 8.  Metabolic Disorders in Multiple Myeloma.

Authors:  Maria Gavriatopoulou; Stavroula A Paschou; Ioannis Ntanasis-Stathopoulos; Meletios A Dimopoulos
Journal:  Int J Mol Sci       Date:  2021-10-22       Impact factor: 5.923

9.  TNFRSF13B is a potential contributor to prostate cancer.

Authors:  Chia-Yang Li; Shu-Pin Huang; Yei-Tsung Chen; Hsin-En Wu; Wei-Chung Cheng; Chao-Yuan Huang; Chia-Cheng Yu; Victor C Lin; Jiun-Hung Geng; Te-Ling Lu; Bo-Ying Bao
Journal:  Cancer Cell Int       Date:  2022-05-06       Impact factor: 6.429

10.  Coinherited genetics of multiple myeloma and its precursor, monoclonal gammopathy of undetermined significance.

Authors:  Alyssa I Clay-Gilmour; Michelle A T Hildebrandt; Elizabeth E Brown; Jonathan N Hofmann; John J Spinelli; Graham G Giles; Wendy Cozen; Parveen Bhatti; Xifeng Wu; Rosalie G Waller; Alem A Belachew; Dennis P Robinson; Aaron D Norman; Jason P Sinnwell; Sonja I Berndt; S Vincent Rajkumar; Shaji K Kumar; Stephen J Chanock; Mitchell J Machiela; Roger L Milne; Susan L Slager; Nicola J Camp; Elad Ziv; Celine M Vachon
Journal:  Blood Adv       Date:  2020-06-23
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