OBJECTIVE: To describe the risk patterns of multiple myeloma in Los Angeles County (LAC). METHODS: Incident multiple myeloma cases diagnosed from 1972 to 1999 were ascertained by the population-based cancer registry for LAC. Average annual age-specific and age-adjusted incidence rates (AAIR), standardized to the 2000 US census age distribution, were calculated using age-, race-, sex- and socioeconomic status (SES)-specific denominators estimated for all years from US census data for 1970, 1980 and 1990. Odds ratios (ORs) for risk by birthplace and religion were estimated using multivariate logistic regression, comparing multiple myeloma patients with other cancer patients. RESULTS: All groups experienced increasing incidence with age; African-Americans experienced the steepest increase which began a decade earlier compared to other groups. Overall incidence rates were 50% higher among males (n = 4,692) than females (n = 4,343) (p < 0.05). AAIRs were highest for African-Americans, followed by Spanish-surnamed whites (SSW), non-Spanish-surnamed whites (NSSW), Filipinos and other Asian groups. Among African-Americans, incidence rates increased with increasing SES. US-born SSW had 14% lower risk compared to non-US born SSW (OR = 0.86, 95% confidence interval [CI] = 0.74-0.99]. Jews had an 11% higher risk compared to Protestants (OR = 1.11; 95% CI = 0.99-1.24). CONCLUSION: Risk patterns suggest a role for both environmental and genetic factors.
OBJECTIVE: To describe the risk patterns of multiple myeloma in Los Angeles County (LAC). METHODS: Incident multiple myeloma cases diagnosed from 1972 to 1999 were ascertained by the population-based cancer registry for LAC. Average annual age-specific and age-adjusted incidence rates (AAIR), standardized to the 2000 US census age distribution, were calculated using age-, race-, sex- and socioeconomic status (SES)-specific denominators estimated for all years from US census data for 1970, 1980 and 1990. Odds ratios (ORs) for risk by birthplace and religion were estimated using multivariate logistic regression, comparing multiple myelomapatients with other cancerpatients. RESULTS: All groups experienced increasing incidence with age; African-Americans experienced the steepest increase which began a decade earlier compared to other groups. Overall incidence rates were 50% higher among males (n = 4,692) than females (n = 4,343) (p < 0.05). AAIRs were highest for African-Americans, followed by Spanish-surnamed whites (SSW), non-Spanish-surnamed whites (NSSW), Filipinos and other Asian groups. Among African-Americans, incidence rates increased with increasing SES. US-born SSW had 14% lower risk compared to non-US born SSW (OR = 0.86, 95% confidence interval [CI] = 0.74-0.99]. Jews had an 11% higher risk compared to Protestants (OR = 1.11; 95% CI = 0.99-1.24). CONCLUSION: Risk patterns suggest a role for both environmental and genetic factors.
Authors: Kristin A Rand; Chi Song; Eric Dean; Daniel J Serie; Karen Curtin; Xin Sheng; Donglei Hu; Carol Ann Huff; Leon Bernal-Mizrachi; Michael H Tomasson; Sikander Ailawadhi; Seema Singhal; Karen Pawlish; Edward S Peters; Cathryn H Bock; Alex Stram; David J Van Den Berg; Christopher K Edlund; David V Conti; Todd Zimmerman; Amie E Hwang; Scott Huntsman; John Graff; Ajay Nooka; Yinfei Kong; Silvana L Pregja; Sonja I Berndt; William J Blot; John Carpten; Graham Casey; Lisa Chu; W Ryan Diver; Victoria L Stevens; Michael R Lieber; Phyllis J Goodman; Anselm J M Hennis; Ann W Hsing; Jayesh Mehta; Rick A Kittles; Suzanne Kolb; Eric A Klein; Cristina Leske; Adam B Murphy; Barbara Nemesure; Christine Neslund-Dudas; Sara S Strom; Ravi Vij; Benjamin A Rybicki; Janet L Stanford; Lisa B Signorello; John S Witte; Christine B Ambrosone; Parveen Bhatti; Esther M John; Leslie Bernstein; Wei Zheng; Andrew F Olshan; Jennifer J Hu; Regina G Ziegler; Sarah J Nyante; Elisa V Bandera; Brenda M Birmann; Sue A Ingles; Michael F Press; Djordje Atanackovic; Martha J Glenn; Lisa A Cannon-Albright; Brandt Jones; Guido Tricot; Thomas G Martin; Shaji K Kumar; Jeffrey L Wolf; Sandra L Deming Halverson; Nathaniel Rothman; Angela R Brooks-Wilson; S Vincent Rajkumar; Laurence N Kolonel; Stephen J Chanock; Susan L Slager; Richard K Severson; Nalini Janakiraman; Howard R Terebelo; Elizabeth E Brown; Anneclaire J De Roos; Ann F Mohrbacher; Graham A Colditz; Graham G Giles; John J Spinelli; Brian C Chiu; Nikhil C Munshi; Kenneth C Anderson; Joan Levy; Jeffrey A Zonder; Robert Z Orlowski; Sagar Lonial; Nicola J Camp; Celine M Vachon; Elad Ziv; Daniel O Stram; Dennis J Hazelett; Christopher A Haiman; Wendy Cozen Journal: Cancer Epidemiol Biomarkers Prev Date: 2016-09-01 Impact factor: 4.254
Authors: Zhaohui Du; Niels Weinhold; Gregory Chi Song; Kristin A Rand; David J Van Den Berg; Amie E Hwang; Xin Sheng; Victor Hom; Sikander Ailawadhi; Ajay K Nooka; Seema Singhal; Karen Pawlish; Edward S Peters; Cathryn Bock; Ann Mohrbacher; Alexander Stram; Sonja I Berndt; William J Blot; Graham Casey; Victoria L Stevens; Rick Kittles; Phyllis J Goodman; W Ryan Diver; Anselm Hennis; Barbara Nemesure; Eric A Klein; Benjamin A Rybicki; Janet L Stanford; John S Witte; Lisa Signorello; Esther M John; Leslie Bernstein; Antoinette M Stroup; Owen W Stephens; Maurizio Zangari; Frits Van Rhee; Andrew Olshan; Wei Zheng; Jennifer J Hu; Regina Ziegler; Sarah J Nyante; Sue Ann Ingles; Michael F Press; John David Carpten; Stephen J Chanock; Jayesh Mehta; Graham A Colditz; Jeffrey Wolf; Thomas G Martin; Michael Tomasson; Mark A Fiala; Howard Terebelo; Nalini Janakiraman; Laurence Kolonel; Kenneth C Anderson; Loic Le Marchand; Daniel Auclair; Brian C-H Chiu; Elad Ziv; Daniel Stram; Ravi Vij; Leon Bernal-Mizrachi; Gareth J Morgan; Jeffrey A Zonder; Carol Ann Huff; Sagar Lonial; Robert Z Orlowski; David V Conti; Christopher A Haiman; Wendy Cozen Journal: Blood Adv Date: 2020-01-14
Authors: Dana Hashim; Zeinab Farhat; Sylvan Wallenstein; Marta Manczuk; Randall F Holcombe; Lorna Thorpe; Maria J Schymura; Roberto G Lucchini; Paolo Boffetta Journal: Eur J Cancer Prev Date: 2016-07 Impact factor: 2.497
Authors: Graça M Dores; Ola Landgren; Katherine A McGlynn; Rochelle E Curtis; Martha S Linet; Susan S Devesa Journal: Br J Haematol Date: 2008-11-11 Impact factor: 6.998
Authors: Brenda M Birmann; Edward Giovannucci; Bernard Rosner; Kenneth C Anderson; Graham A Colditz Journal: Cancer Epidemiol Biomarkers Prev Date: 2007-07 Impact factor: 4.254