P J Vinholt1, A M Hvas2, H Frederiksen3, L Bathum4, M K Jørgensen5, M Nybo6. 1. Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Denmark. Electronic address: pernille.vinholt@rsyd.dk. 2. Department of Clinical Biochemistry, Aarhus University Hospital, Denmark. 3. Department of Haematology, Odense University Hospital, Denmark. 4. Department of Clinical Biochemistry, Amager Hvidovre Hospital, Denmark. 5. Department of Clinical Biochemistry, Slagelse-Naestved Hospital, Denmark. 6. Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Denmark.
Abstract
INTRODUCTION: Platelet count is used to determine bleeding risk and monitoring thrombopoiesis. While abnormal platelet counts are associated with mortality and morbidity, it is unclear whether it also apply to platelet counts within reference range. We investigated the relationship between platelet count (100-450×109/L) and mortality, development of future cardiovascular disease (myocardial infarction, ischaemic stroke, or peripheral vascular disease), venous thromboembolism, bleeding or cancer in the general population. MATERIAL AND METHODS: We conducted a register-based cohort study of 21,252 adults (≥20years) from the Danish General Suburban Population Study (GESUS). Laboratory results from GESUS were linked to information from national registers regarding morbidity and death. Cox proportional hazard regression was conducted with adjustment for age, sex, smoking status, haemoglobin, leukocyte count, C-reactive protein and Charlson comorbidity index. RESULTS: We found a U-shaped relationship between mortality and platelet count. Mortality was significantly increased for platelet count <175×109/L or >300×109/L. When categorizing platelet count using the interval 201-250×109/L as reference group, platelet count 301-450×109/L was associated with mortality, adjusted hazard ratio (HR)=1.42(95% CI 1.06-1.90) and cardiovascular disease, adjusted HR=1.32 (95% CI 1.03-1.69). Platelet count 100-200×109/L was associated with future cancer, adjusted HR=1.28(95% CI 1.05-1.57), but not with future bleeding or venous thromboembolism. CONCLUSIONS: Platelet count is associated with mortality, future cardiovascular disease, and future cancer.
INTRODUCTION: Platelet count is used to determine bleeding risk and monitoring thrombopoiesis. While abnormal platelet counts are associated with mortality and morbidity, it is unclear whether it also apply to platelet counts within reference range. We investigated the relationship between platelet count (100-450×109/L) and mortality, development of future cardiovascular disease (myocardial infarction, ischaemic stroke, or peripheral vascular disease), venous thromboembolism, bleeding or cancer in the general population. MATERIAL AND METHODS: We conducted a register-based cohort study of 21,252 adults (≥20years) from the Danish General Suburban Population Study (GESUS). Laboratory results from GESUS were linked to information from national registers regarding morbidity and death. Cox proportional hazard regression was conducted with adjustment for age, sex, smoking status, haemoglobin, leukocyte count, C-reactive protein and Charlson comorbidity index. RESULTS: We found a U-shaped relationship between mortality and platelet count. Mortality was significantly increased for platelet count <175×109/L or >300×109/L. When categorizing platelet count using the interval 201-250×109/L as reference group, platelet count 301-450×109/L was associated with mortality, adjusted hazard ratio (HR)=1.42(95% CI 1.06-1.90) and cardiovascular disease, adjusted HR=1.32 (95% CI 1.03-1.69). Platelet count 100-200×109/L was associated with future cancer, adjusted HR=1.28(95% CI 1.05-1.57), but not with future bleeding or venous thromboembolism. CONCLUSIONS: Platelet count is associated with mortality, future cardiovascular disease, and future cancer.
Authors: Tessa J Barrett; Martin Schlegel; Felix Zhou; Mike Gorenchtein; Jennifer Bolstorff; Kathryn J Moore; Edward A Fisher; Jeffrey S Berger Journal: Sci Transl Med Date: 2019-11-06 Impact factor: 17.956
Authors: Bianca Dahlen; Felix Müller; Sven-Oliver Tröbs; Marc William Heidorn; Andreas Schulz; Natalie Arnold; M Iris Hermanns; Sören Schwuchow-Thonke; Jürgen H Prochaska; Tommaso Gori; Hugo Ten Cate; Karl J Lackner; Thomas Münzel; Philipp S Wild; Marina Panova-Noeva Journal: Front Cardiovasc Med Date: 2021-06-16