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Literature DB >> 27585747

Regulation of sarcoplasmic reticulum Ca²⁺ release by serine-threonine phosphatases in the heart.

Abstract

The amount and timing of Ca2+ release from the sarcoplasmic reticulum (SR) during cardiac cycle are the main determinants of cardiac contractility. Reversible phosphorylation of the SR Ca2+ release channel, ryanodine receptor type 2 (RyR2) is the central mechanism of regulation of Ca2+ release in cardiomyocytes. Three major serine-threonine phosphatases including PP1, PP2A and PP2B (calcineurin) have been implicated in modulation of RyR2 function. Changes in expression levels of these phosphatases, their activity and targeting to the RyR2 macromolecular complex were demonstrated in many animal models of cardiac disease and humans and are implicated in cardiac arrhythmia and heart failure. Here we review evidence in support of regulation of RyR2-mediated SR Ca2+ release by serine-threonine phosphatases and the role and mechanisms of dysregulation of phosphatases in various disease states.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Cardiac arrhythmia; Heart failure; Ryanodine receptor; Sarcoplasmic reticulum calcium release; Serine threonine phosphatase

Mesh：

Substances：

Year: 2016 PMID： 27585747 PMCID： PMC5180210 DOI： 10.1016/j.yjmcc.2016.08.020

Source DB: PubMed Journal: J Mol Cell Cardiol ISSN： 0022-2828 Impact factor: 5.000

141 in total

1. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.

Authors: S O Marx; S Reiken; Y Hisamatsu; T Jayaraman; D Burkhoff; N Rosemblit; A R Marks
Journal: Cell Date: 2000-05-12 Impact factor: 41.582

2. Protein phosphatases decrease sarcoplasmic reticulum calcium content by stimulating calcium release in cardiac myocytes.

Authors: Dmitry Terentyev; Serge Viatchenko-Karpinski; Inna Gyorke; Radmila Terentyeva; Sandor Gyorke
Journal: J Physiol Date: 2003-08-01 Impact factor: 5.182

3. Arrhythmogenic consequences of intracellular calcium waves.

Authors: Lai-Hua Xie; James N Weiss
Journal: Am J Physiol Heart Circ Physiol Date: 2009-06-26 Impact factor: 4.733

4. Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase a.

Authors: C L Antos; N Frey; S O Marx; S Reiken; M Gaburjakova; J A Richardson; A R Marks; E N Olson
Journal: Circ Res Date: 2001-11-23 Impact factor: 17.367

5. Diminished basal phosphorylation level of phospholamban in the postinfarction remodeled rat ventricle: role of beta-adrenergic pathway, G(i) protein, phosphodiesterase, and phosphatases.

Authors: B Huang; S Wang; D Qin; M Boutjdir; N El-Sherif
Journal: Circ Res Date: 1999-10-29 Impact factor: 17.367

6. Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.

Authors: Xander H T Wehrens; Stephan E Lehnart; Steven Reiken; John A Vest; Anetta Wronska; Andrew R Marks
Journal: Proc Natl Acad Sci U S A Date: 2006-01-06 Impact factor: 11.205

7. Defective cardiac ryanodine receptor regulation during atrial fibrillation.

Authors: John A Vest; Xander H T Wehrens; Steven R Reiken; Stephan E Lehnart; Dobromir Dobrev; Parag Chandra; Peter Danilo; Ursula Ravens; Michael R Rosen; Andrew R Marks
Journal: Circulation Date: 2005-04-26 Impact factor: 29.690

8. Dominant-negative control of cAMP-dependent IKs upregulation in human long-QT syndrome type 1.

Authors: Jordi Heijman; Roel L H M G Spätjens; Sandrine R M Seyen; Viola Lentink; Helma J H Kuijpers; Inge R Boulet; Leon J de Windt; Miren David; Paul G A Volders
Journal: Circ Res Date: 2011-11-17 Impact factor: 17.367

9. Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy.

Authors: Sameer Ather; Wei Wang; Qiongling Wang; Na Li; Mark E Anderson; Xander H T Wehrens
Journal: Heart Rhythm Date: 2012-12-12 Impact factor: 6.343

10. Evidence for protein phosphatase inhibitor-1 playing an amplifier role in beta-adrenergic signaling in cardiac myocytes.

Authors: Ali El-Armouche; Thomas Rau; Oliver Zolk; Diana Ditz; Torsten Pamminger; Wolfram-H Zimmermann; Elmar Jäckel; Sian E Harding; Peter Boknik; Joachim Neumann; Thomas Eschenhagen
Journal: FASEB J Date: 2003-01-02 Impact factor: 5.191

17 in total

1. Successful overexpression of wild-type inhibitor-2 of PP1 in cardiovascular cells.

Authors: Thorsten Krause; Stefanie Grote-Wessels; Felix Balzer; Peter Boknik; Ulrich Gergs; Uwe Kirchhefer; Igor B Buchwalow; Frank U Müller; Wilhelm Schmitz; Joachim Neumann
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2018-05-24 Impact factor: 3.000

Review 2. Serine/Threonine Phosphatases in Atrial Fibrillation.

Authors: Jordi Heijman; Shokoufeh Ghezelbash; Xander H T Wehrens; Dobromir Dobrev
Journal: J Mol Cell Cardiol Date: 2017-01-07 Impact factor: 5.000

Review 3. Redefining the role of biomarkers in heart failure trials: expert consensus document.

Authors: Frank Kramer; Hani N Sabbah; James J Januzzi; Faiez Zannad; J Peter van Tintelen; Erik B Schelbert; Raymond J Kim; Hendrik Milting; Richardus Vonk; Brien Neudeck; Richard Clark; Klaus Witte; Wilfried Dinh; Burkert Pieske; Javed Butler; Mihai Gheorghiade
Journal: Heart Fail Rev Date: 2017-05 Impact factor: 4.214

Review 4. Structure-function relationships and modifications of cardiac sarcoplasmic reticulum Ca2+-transport.

Authors: M Nusier; A K Shah; N S Dhalla
Journal: Physiol Res Date: 2021-12-30 Impact factor: 2.139

5. Novel role of the ER/SR Ca²⁺ sensor STIM1 in the regulation of cardiac metabolism.

Authors: Helen E Collins; Betty M Pat; Luyun Zou; Silvio H Litovsky; Adam R Wende; Martin E Young; John C Chatham
Journal: Am J Physiol Heart Circ Physiol Date: 2018-12-21 Impact factor: 4.733

Review 6. Sarcoplasmic reticulum-mitochondria communication; implications for cardiac arrhythmia.

Authors: Shanna Hamilton; Radmila Terentyeva; Richard T Clements; Andriy E Belevych; Dmitry Terentyev
Journal: J Mol Cell Cardiol Date: 2021-04-17 Impact factor: 5.000

7. In vivo administration of urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats.

Authors: Monia Savi; Leonardo Bocchi; Pedro Mena; Margherita Dall'Asta; Alan Crozier; Furio Brighenti; Donatella Stilli; Daniele Del Rio
Journal: Cardiovasc Diabetol Date: 2017-07-06 Impact factor: 9.951

Regulation of sarcoplasmic reticulum Ca²⁺ release by serine-threonine phosphatases in the heart.

1. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.

2. Protein phosphatases decrease sarcoplasmic reticulum calcium content by stimulating calcium release in cardiac myocytes.

3. Arrhythmogenic consequences of intracellular calcium waves.

4. Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase a.

5. Diminished basal phosphorylation level of phospholamban in the postinfarction remodeled rat ventricle: role of beta-adrenergic pathway, G(i) protein, phosphodiesterase, and phosphatases.

6. Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.

7. Defective cardiac ryanodine receptor regulation during atrial fibrillation.

8. Dominant-negative control of cAMP-dependent IKs upregulation in human long-QT syndrome type 1.

9. Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy.

10. Evidence for protein phosphatase inhibitor-1 playing an amplifier role in beta-adrenergic signaling in cardiac myocytes.

1. Successful overexpression of wild-type inhibitor-2 of PP1 in cardiovascular cells.

Review 2. Serine/Threonine Phosphatases in Atrial Fibrillation.

Review 3. Redefining the role of biomarkers in heart failure trials: expert consensus document.

Review 4. Structure-function relationships and modifications of cardiac sarcoplasmic reticulum Ca2+-transport.

5. Novel role of the ER/SR Ca²⁺ sensor STIM1 in the regulation of cardiac metabolism.

Review 6. Sarcoplasmic reticulum-mitochondria communication; implications for cardiac arrhythmia.

7. In vivo administration of urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats.

Review 8. Proarrhythmic Remodeling of Calcium Homeostasis in Cardiac Disease; Implications for Diabetes and Obesity.

Review 9. Serine-threonine protein phosphatase regulation of Cx43 dephosphorylation in arrhythmogenic disorders.

Review 10. Mechanisms underlying pathological Ca²⁺ handling in diseases of the heart.

Review 2. Serine/Threonine Phosphatases in Atrial Fibrillation.

Review 3. Redefining the role of biomarkers in heart failure trials: expert consensus document.

Review 4. Structure-function relationships and modifications of cardiac sarcoplasmic reticulum Ca2+-transport.

Review 6. Sarcoplasmic reticulum-mitochondria communication; implications for cardiac arrhythmia.

Review 8. Proarrhythmic Remodeling of Calcium Homeostasis in Cardiac Disease; Implications for Diabetes and Obesity.

Review 9. Serine-threonine protein phosphatase regulation of Cx43 dephosphorylation in arrhythmogenic disorders.

Review 10. Mechanisms underlying pathological Ca2+ handling in diseases of the heart.

Review 10. Mechanisms underlying pathological Ca²⁺ handling in diseases of the heart.