Susanne Schulz1, Henriette Lüdike2, Madlen Lierath2, Axel Schlitt3, Karl Werdan4, Britt Hofmann5, Christiane Gläser6, Hans-Günter Schaller2, Stefan Reichert2. 1. Department of Operative Dentistry and Periodontology, Martin-Luther University Halle-Wittenberg, Germany. Electronic address: susanne.schulz@medizin.uni-halle.de. 2. Department of Operative Dentistry and Periodontology, Martin-Luther University Halle-Wittenberg, Germany. 3. Department of Medicine III, Heart Centre of the University Clinics Halle (Saale), Martin-Luther University Halle-Wittenberg, Germany; Department of Cardiology, Paracelsus-Harz-Clinic Bad Suderode, Germany. 4. Department of Medicine III, Heart Centre of the University Clinics Halle (Saale), Martin-Luther University Halle-Wittenberg, Germany. 5. Department of Cardiothoracic Surgery, Heart Centre of the University Clinics Halle (Saale), Martin-Luther University Halle-Wittenberg, Germany. 6. Institute of Human Genetics and Medical Biology, Martin-Luther University Halle-Wittenberg, Germany.
Abstract
BACKGROUND: The aim of this analysis was to evaluate the importance of C-reactive protein levels and genetic variants of CRP as prognostic markers for further cardiovascular (CV) events (3-year follow-up) in a cohort of in-patients with cardiovascular disease (CVD) patients. METHODS AND RESULTS: Patients with angiographic proven CVD (n=939) were prospectively included. The three-year CV outcome of the patients was evaluated considering the predefined, combined endpoint (CV death, death from stroke, myocardial infarction, and stroke/TIA). Polymorphisms rs1800947, rs1417938, rs1130864, rs3093077 were analysed. In Kaplan-Meier survival curve and Cox regression increased CRP levels of ⩾5mg/l (log-rank test: p=0.001, Cox regression: hazard ratio=1.77, 95% CI: 1.2-2.7) and the GG genotype of rs1800947 (log-rank test: p=0.01, Cox regression: hazard ratio=1.99, 95% CI: 1.1-3.6) were associated with the incidence of the combined endpoint. CONCLUSIONS: Both a CRP level ⩾5mg/l and SNP rs1800947 of the CRP gene were independent risk factors for further adverse CV events among patients with CVD within three years follow-up.
BACKGROUND: The aim of this analysis was to evaluate the importance of C-reactive protein levels and genetic variants of CRP as prognostic markers for further cardiovascular (CV) events (3-year follow-up) in a cohort of in-patients with cardiovascular disease (CVD) patients. METHODS AND RESULTS:Patients with angiographic proven CVD (n=939) were prospectively included. The three-year CV outcome of the patients was evaluated considering the predefined, combined endpoint (CV death, death from stroke, myocardial infarction, and stroke/TIA). Polymorphisms rs1800947, rs1417938, rs1130864, rs3093077 were analysed. In Kaplan-Meier survival curve and Cox regression increased CRP levels of ⩾5mg/l (log-rank test: p=0.001, Cox regression: hazard ratio=1.77, 95% CI: 1.2-2.7) and the GG genotype of rs1800947 (log-rank test: p=0.01, Cox regression: hazard ratio=1.99, 95% CI: 1.1-3.6) were associated with the incidence of the combined endpoint. CONCLUSIONS: Both a CRP level ⩾5mg/l and SNP rs1800947 of the CRP gene were independent risk factors for further adverse CV events among patients with CVD within three years follow-up.
Authors: Stefan Reichert; Britt Hofmann; Michael Kohnert; Alexander Navarrete Santos; Lisa Friebe; Julia Grollmitz; Hans-Günter Schaller; Susanne Schulz Journal: J Clin Med Date: 2022-07-15 Impact factor: 4.964
Authors: Mario Di Napoli; Mark Slevin; Aurel Popa-Wagner; Puneetpal Singh; Simona Lattanzi; Afshin A Divani Journal: Front Immunol Date: 2018-09-11 Impact factor: 7.561