J Zweegers1, J M M Groenewoud2, J M P A van den Reek1, M E Otero1, P C M van de Kerkhof1, R J B Driessen1, P P M van Lümig1, M D Njoo3, P M Ossenkoppele3, J M Mommers4, M I A Koetsier5, W P Arnold6, M P M Andriessen7, A L A Kuijpers8, M A M Berends9, W Kievit2, E M G J de Jong1. 1. Department of Dermatology, Radboud University Medical Center, Nijmegen, the Netherlands. 2. Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, the Netherlands. 3. Department of Dermatology, Ziekenhuisgroep Twente, Almelo/Hengelo, the Netherlands. 4. Department of Dermatology, St Anna Ziekenhuis, Geldrop, the Netherlands. 5. Department of Dermatology, Gelre Ziekenhuizen, Apeldoorn, the Netherlands. 6. Department of Dermatology, Ziekenhuis Gelderse Vallei, Ede, the Netherlands. 7. Department of Dermatology, Jeroen Bosch Ziekenhuis, Den Bosch, the Netherlands. 8. Department of Dermatology, Maxima Medisch Centrum, Eindhoven/Veldhoven, the Netherlands. 9. Department of Dermatology, Slingeland Ziekenhuis, Doetinchem, the Netherlands.
Abstract
BACKGROUND: The efficacy of etanercept and ustekinumab in psoriasis has been compared in one randomized controlled trial. Comparison of the long-term effectiveness of biologics in daily-practice psoriasis treatment is currently lacking. OBJECTIVES: To compare the effectiveness between the three widely used outpatient biologics adalimumab, etanercept and ustekinumab in daily-practice psoriasis treatment and to correct for confounders. METHODS: Data were extracted from the prospective, multicentre BioCAPTURE registry. Multilevel linear regression analyses (MLRAs) and generalized estimating equation (GEE) analyses were performed on the course of mean Psoriasis Area and Severity Index (PASI) and PASI 75 (≥ 75% reduction vs. baseline). Both models were corrected for confounders. Subgroup analyses for biological dose were performed. RESULTS: We included 356 patients with 513 treatment episodes: 178 adalimumab, 245 etanercept and 90 ustekinumab. MLRA showed a similar effectiveness between adalimumab, etanercept and ustekinumab after 1 year, but the highest effectiveness for ustekinumab during 5 years of treatment (P = 0·047; ustekinumab vs. etanercept, P = 0·019). GEE analysis revealed a higher chance of attaining PASI 75 with adalimumab and ustekinumab than with etanercept at 1 year of treatment. A higher than label dose was more often used in patients treated with etanercept (adalimumab, etanercept and ustekinumab: respectively 31·5%, 55·1% and 17% after 1 year, P < 0·001; 39·3%, 71·4% and 24% after 5 years, P < 0·001). CONCLUSIONS: Compared with etanercept, ustekinumab had the highest effectiveness during 5 years of treatment. Patients receiving adalimumab and ustekinumab more often reached PASI 75 than those on etanercept at 1 year of treatment. Dose escalation was more frequent in etanercept and adalimumab than in ustekinumab.
RCT Entities:
BACKGROUND: The efficacy of etanercept and ustekinumab in psoriasis has been compared in one randomized controlled trial. Comparison of the long-term effectiveness of biologics in daily-practice psoriasis treatment is currently lacking. OBJECTIVES: To compare the effectiveness between the three widely used outpatient biologics adalimumab, etanercept and ustekinumab in daily-practice psoriasis treatment and to correct for confounders. METHODS: Data were extracted from the prospective, multicentre BioCAPTURE registry. Multilevel linear regression analyses (MLRAs) and generalized estimating equation (GEE) analyses were performed on the course of mean Psoriasis Area and Severity Index (PASI) and PASI 75 (≥ 75% reduction vs. baseline). Both models were corrected for confounders. Subgroup analyses for biological dose were performed. RESULTS: We included 356 patients with 513 treatment episodes: 178 adalimumab, 245 etanercept and 90 ustekinumab. MLRA showed a similar effectiveness between adalimumab, etanercept and ustekinumab after 1 year, but the highest effectiveness for ustekinumab during 5 years of treatment (P = 0·047; ustekinumab vs. etanercept, P = 0·019). GEE analysis revealed a higher chance of attaining PASI 75 with adalimumab and ustekinumab than with etanercept at 1 year of treatment. A higher than label dose was more often used in patients treated with etanercept (adalimumab, etanercept and ustekinumab: respectively 31·5%, 55·1% and 17% after 1 year, P < 0·001; 39·3%, 71·4% and 24% after 5 years, P < 0·001). CONCLUSIONS: Compared with etanercept, ustekinumab had the highest effectiveness during 5 years of treatment. Patients receiving adalimumab and ustekinumab more often reached PASI 75 than those on etanercept at 1 year of treatment. Dose escalation was more frequent in etanercept and adalimumab than in ustekinumab.
Authors: Marloes E Van Muijen; Sarah E Thomas; Hans M M Groenewoud; Marisol E Otero; Paul M Ossenkoppele; Marcellus D Njoo; Sharon R P Dodemont; Else N Kop; Maartje A M Berends; Marjolein I A Koetsier; Johannes M Mommers; John E M Körver; Ron A Tupker; Marjolein S De Bruin-Weller; Lizelotte J M T Weppner-Parren; Bas Peters; Marloes M Kleinpenning; Astrid L A Kuijpers; W Peter Arnold; Paula P M Van Lümig; Juul M P A Van den Reek; Elke M G J De Jong Journal: Acta Derm Venereol Date: 2022-05-16 Impact factor: 3.875
Authors: Selma Atalay; Juul M P A van den Reek; Lieke J van Vugt; Marisol E Otero; Peter C M van de Kerkhof; Alfons A den Broeder; Wietske Kievit; Elke M G J de Jong Journal: BMC Dermatol Date: 2017-05-08
Authors: R Bissonnette; T Luger; D Thaçi; D Toth; A Lacombe; S Xia; R Mazur; M Patekar; P Charef; M Milutinovic; C Leonardi; U Mrowietz Journal: J Eur Acad Dermatol Venereol Date: 2018-03-22 Impact factor: 6.166
Authors: K A Papp; M G Lebwohl; L Puig; M Ohtsuki; S Beissert; J Zeng; S Rubant; R Sinvhal; Y Zhao; A M Soliman; G Alperovich; C Leonardi Journal: Br J Dermatol Date: 2021-09-21 Impact factor: 11.113