| Literature DB >> 27578002 |
Li Zhang1,2, Jianghua Wang2, Yongquan Wang2, Yiqun Zhang3, Patricia Castro2, Longjiang Shao2, Arun Sreekumar4,5,6, Nagireddy Putluri4,5,6, Nilanjan Guha7, Saligrama Deepak7, Arunkumar Padmanaban7, Chad J Creighton3,8, Michael Ittmann9.
Abstract
Incidence and mortality rates for prostate cancer are higher in African-American (AA) men than in European-American (EA) men, but the biologic basis for this disparity is unclear. We carried out a detailed analysis of gene expression changes in prostate cancer compared with their matched benign tissues in a cohort of AA men and compared them with existing data from EA men. In this manner, we identified MNX1 as a novel oncogene upregulated to a relatively greater degree in prostate cancer from AA men. Androgen and AKT signaling play a central role in the pathogenesis of prostate cancer and we found that both of these signaling pathways increased MNX1 expression. MNX1 in turn upregulated lipid synthesis by stimulating expression of SREBP1 and fatty acid synthetase. Our results define MNX1 as a novel targetable oncogene increased in AA prostate cancer that is associated with aggressive disease. Cancer Res; 76(21); 6290-8. ©2016 AACR. ©2016 American Association for Cancer Research.Entities:
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Year: 2016 PMID： 27578002 PMCID： PMC5093064 DOI： 10.1158/0008-5472.CAN-16-0087
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701