| Literature DB >> 35121907 |
Zhongyi Hu1,2, Jiao Yuan1,2, Meixiao Long3, Junjie Jiang1,2, Youyou Zhang1,2, Tianli Zhang1, Mu Xu1, Yi Fan4, Janos L Tanyi2, Kathleen T Montone5, Omid Tavana6, Ho Man Chan6, Xiaowen Hu7,8, Robert H Vonderheide9, Lin Zhang10,11,12.
Abstract
Cell-surface proteins (SPs) are a rich source of immune and targeted therapies. By systematically integrating single-cell and bulk genomics, functional studies and target actionability, in the present study we comprehensively identify and annotate genes encoding SPs (GESPs) pan-cancer. We characterize GESP expression patterns, recurrent genomic alterations, essentiality, receptor-ligand interactions and therapeutic potential. We also find that mRNA expression of GESPs is cancer-type specific and positively correlates with protein expression, and that certain GESP subgroups function as common or specific essential genes for tumor cell growth. We also predict receptor-ligand interactions substantially deregulated in cancer and, using systems biology approaches, we identify cancer-specific GESPs with therapeutic potential. We have made this resource available through the Cancer Surfaceome Atlas ( http://fcgportal.org/TCSA ) within the Functional Cancer Genome data portal.Entities:
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Year: 2021 PMID： 35121907 DOI： 10.1038/s43018-021-00282-w
Source DB: PubMed Journal: Nat Cancer ISSN： 2662-1347