| Literature DB >> 27576121 |
Saravana K Ramasamy1,2, Anjali P Kusumbe1,2, Tomer Itkin3, Shiri Gur-Cohen3, Tsvee Lapidot3, Ralf H Adams1,2.
Abstract
In addition to their conventional role as a versatile transport system, blood vessels provide signals controlling organ development, regeneration, and stem cell behavior. In the skeletal system, certain capillaries support perivascular osteoprogenitor cells and thereby control bone formation. Blood vessels are also a critical component of niche microenvironments for hematopoietic stem cells. Here we discuss key pathways and factors controlling endothelial cell behavior in bone, the role of vessels in osteogenesis, and the nature of vascular stem cell niches in bone marrow.Keywords: angiocrine factors; bone angiogenesis; hematopoietic stem cells; vascular niche
Mesh：
Year: 2016 PMID： 27576121 DOI： 10.1146/annurev-cellbio-111315-124936
Source DB: PubMed Journal: Annu Rev Cell Dev Biol ISSN： 1081-0706 Impact factor: 13.827