Jeannie S Huang1, Laura Terrones, Alan N Simmons, Walter Kaye, Irina Strigo. 1. *Department of Pediatrics, Rady Children's Hospital and University of California San Diego, San Diego †Department of Psychiatry, University of California San Diego, La Jolla ‡Center of Excellence Stress and Mental Health, Veterans Affairs Health System §San Francisco Veterans Affairs Medical Center, San Francisco, CA.
Abstract
BACKGROUND: Brain-gut axis signaling modifies gastrointestinal symptomatology. Altered neural processing of intestinal pain signals involves interoceptive brain regions in adults with functional and inflammatory gastrointestinal disorders. Although these disorders frequently present in childhood, there are no published studies in youth. We determined whether neural processing of somatic pain stimuli differs in adolescents and young adults (AYA) with irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), as compared to healthy controls (HC). METHODS: IBS and IBD AYA (16-20 years) underwent anticipated and thermal pain stimuli of low and high intensity on their forearm and simultaneous blood oxygen level-dependent functional magnetic resonance imaging. Data from adult HC were used for comparison. Subjects answered surveys evaluating alexithymia, anxiety, depression, and pain catastrophizing. Group data were compared using linear mixed effects and analysis of variance. RESULTS: Study groups were similar by sex but not age. Significant group by pain condition interactions were observed in interoceptive brain regions during pain anticipation, and within perceptual brain regions during perceived pain. Higher activation within interoceptive brain regions during anticipated pain was observed in IBS compared with IBD and HC subjects. IBD patients demonstrated increased activation in perceptual brain regions during experienced pain as compared to IBS and HC. CONCLUSIONS: IBS and IBD AYA demonstrate altered neural processing of somatic pain compared with each other and with HC. Our results suggest that neuromodulatory interventions targeting interoceptive brain circuits in IBS and perceptual brain regions in IBD may be effective.
BACKGROUND: Brain-gut axis signaling modifies gastrointestinal symptomatology. Altered neural processing of intestinal pain signals involves interoceptive brain regions in adults with functional and inflammatory gastrointestinal disorders. Although these disorders frequently present in childhood, there are no published studies in youth. We determined whether neural processing of somatic pain stimuli differs in adolescents and young adults (AYA) with irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), as compared to healthy controls (HC). METHODS:IBS and IBD AYA (16-20 years) underwent anticipated and thermal pain stimuli of low and high intensity on their forearm and simultaneous blood oxygen level-dependent functional magnetic resonance imaging. Data from adult HC were used for comparison. Subjects answered surveys evaluating alexithymia, anxiety, depression, and pain catastrophizing. Group data were compared using linear mixed effects and analysis of variance. RESULTS: Study groups were similar by sex but not age. Significant group by pain condition interactions were observed in interoceptive brain regions during pain anticipation, and within perceptual brain regions during perceived pain. Higher activation within interoceptive brain regions during anticipated pain was observed in IBS compared with IBD and HC subjects. IBDpatients demonstrated increased activation in perceptual brain regions during experienced pain as compared to IBS and HC. CONCLUSIONS:IBS and IBD AYA demonstrate altered neural processing of somatic pain compared with each other and with HC. Our results suggest that neuromodulatory interventions targeting interoceptive brain circuits in IBS and perceptual brain regions in IBD may be effective.
Authors: Lori Haase; Nate J Thom; Akanksha Shukla; Paul W Davenport; Alan N Simmons; Elizabeth A Stanley; Martin P Paulus; Douglas C Johnson Journal: Soc Cogn Affect Neurosci Date: 2014-04-08 Impact factor: 3.436
Authors: Mats B O Larsson; Kirsten Tillisch; A D Craig; Maria Engström; Jennifer Labus; Bruce Naliboff; Peter Lundberg; Magnus Ström; Emeran A Mayer; Susanna A Walter Journal: Gastroenterology Date: 2011-11-19 Impact factor: 22.682
Authors: Susan A Gaylord; Olafur S Palsson; Eric L Garland; Keturah R Faurot; Rebecca S Coble; J Douglas Mann; William Frey; Karyn Leniek; William E Whitehead Journal: Am J Gastroenterol Date: 2011-06-21 Impact factor: 10.864
Authors: Irina A Strigo; Scott C Matthews; Alan N Simmons; Tyson Oberndorfer; Megan Klabunde; Lindsay E Reinhardt; Walter H Kaye Journal: Int J Eat Disord Date: 2012-07-27 Impact factor: 4.861
Authors: Natoshia R Cunningham; Hadas Nahman-Averbuch; Gregory R Lee; Christopher D King; Robert C Coghill Journal: Pain Date: 2022-01-28 Impact factor: 7.926
Authors: Catherine S Hubbard; Lino Becerra; Nicole Heinz; Allison Ludwick; Tali Rasooly; Anastasia Yendiki; Rina Wu; Neil L Schechter; Samuel Nurko; David Borsook Journal: eNeuro Date: 2018-08-14