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Literature DB >> 27574551

Regulation of CTNNB1 signaling in gastric cancer and stem cells.

Shihori Tanabe¹, Kazuhiko Aoyagi¹, Hiroshi Yokozaki¹, Hiroki Sasaki¹.

Abstract

Recent research has shown that the alteration of combinations in gene expression contributes to cellular phenotypic changes. Previously, it has been demonstrated that the combination of cadherin 1 and cadherin 2 expression can identify the diffuse-type and intestinal-type gastric cancers. Although the diffuse-type gastric cancer has been resistant to treatment, the precise mechanism and phenotypic involvement has not been revealed. It may be possible that stem cells transform into gastric cancer cells, possibly through the involvement of a molecule alteration and signaling mechanism. In this review article, we focus on the role of catenin beta 1 (CTNNB1 or β-catenin) and describe the regulation of CTNNB1 signaling in gastric cancer and stem cells.

Entities: Disease Gene

Keywords: CTNNB1 signaling; Epithelial-mesenchymal transition; Gastric cancer; Stem cell; β-catenin

Year: 2016 PMID： 27574551 PMCID： PMC4980649 DOI： 10.4251/wjgo.v8.i8.592

Source DB: PubMed Journal: World J Gastrointest Oncol

55 in total

1. Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling.

Authors: W Liu; X Dong; M Mai; R S Seelan; K Taniguchi; K K Krishnadath; K C Halling; J M Cunningham; L A Boardman; C Qian; E Christensen; S S Schmidt; P C Roche; D I Smith; S N Thibodeau
Journal: Nat Genet Date: 2000-10 Impact factor: 38.330

2. SDF-1/CXCR4 promotes epithelial-mesenchymal transition and progression of colorectal cancer by activation of the Wnt/β-catenin signaling pathway.

Authors: Ting-Hua Hu; Yu Yao; Shuo Yu; Li-Li Han; Wen-Juan Wang; Hui Guo; Tao Tian; Zhi-Pin Ruan; Xiao-Min Kang; Jing Wang; Shu-Hong Wang; Ke-Jun Nan
Journal: Cancer Lett Date: 2014-08-20 Impact factor: 8.679

3. Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions.

Authors: Wen Luo; Haiying Zou; Lihua Jin; Shuyong Lin; Qinxi Li; Zhiyun Ye; Hongliang Rui; Sheng-Cai Lin
Journal: J Biol Chem Date: 2004-12-05 Impact factor: 5.157

4. Identification of c-MYC as a target of the APC pathway.

Authors: T C He; A B Sparks; C Rago; H Hermeking; L Zawel; L T da Costa; P J Morin; B Vogelstein; K W Kinzler
Journal: Science Date: 1998-09-04 Impact factor: 47.728

5. Divergent clonal selection dominates medulloblastoma at recurrence.

Authors: A Sorana Morrissy; Livia Garzia; David J H Shih; Scott Zuyderduyn; Xi Huang; Patryk Skowron; Marc Remke; Florence M G Cavalli; Vijay Ramaswamy; Patricia E Lindsay; Salomeh Jelveh; Laura K Donovan; Xin Wang; Betty Luu; Kory Zayne; Yisu Li; Chelsea Mayoh; Nina Thiessen; Eloi Mercier; Karen L Mungall; Yusanne Ma; Kane Tse; Thomas Zeng; Karey Shumansky; Andrew J L Roth; Sohrab Shah; Hamza Farooq; Noriyuki Kijima; Borja L Holgado; John J Y Lee; Stuart Matan-Lithwick; Jessica Liu; Stephen C Mack; Alex Manno; K A Michealraj; Carolina Nor; John Peacock; Lei Qin; Juri Reimand; Adi Rolider; Yuan Y Thompson; Xiaochong Wu; Trevor Pugh; Adrian Ally; Mikhail Bilenky; Yaron S N Butterfield; Rebecca Carlsen; Young Cheng; Eric Chuah; Richard D Corbett; Noreen Dhalla; An He; Darlene Lee; Haiyan I Li; William Long; Michael Mayo; Patrick Plettner; Jenny Q Qian; Jacqueline E Schein; Angela Tam; Tina Wong; Inanc Birol; Yongjun Zhao; Claudia C Faria; José Pimentel; Sofia Nunes; Tarek Shalaby; Michael Grotzer; Ian F Pollack; Ronald L Hamilton; Xiao-Nan Li; Anne E Bendel; Daniel W Fults; Andrew W Walter; Toshihiro Kumabe; Teiji Tominaga; V Peter Collins; Yoon-Jae Cho; Caitlin Hoffman; David Lyden; Jeffrey H Wisoff; James H Garvin; Duncan S Stearns; Luca Massimi; Ulrich Schüller; Jaroslav Sterba; Karel Zitterbart; Stephanie Puget; Olivier Ayrault; Sandra E Dunn; Daniela P C Tirapelli; Carlos G Carlotti; Helen Wheeler; Andrew R Hallahan; Wendy Ingram; Tobey J MacDonald; Jeffrey J Olson; Erwin G Van Meir; Ji-Yeoun Lee; Kyu-Chang Wang; Seung-Ki Kim; Byung-Kyu Cho; Torsten Pietsch; Gudrun Fleischhack; Stephan Tippelt; Young Shin Ra; Simon Bailey; Janet C Lindsey; Steven C Clifford; Charles G Eberhart; Michael K Cooper; Roger J Packer; Maura Massimino; Maria Luisa Garre; Ute Bartels; Uri Tabori; Cynthia E Hawkins; Peter Dirks; Eric Bouffet; James T Rutka; Robert J Wechsler-Reya; William A Weiss; Lara S Collier; Adam J Dupuy; Andrey Korshunov; David T W Jones; Marcel Kool; Paul A Northcott; Stefan M Pfister; David A Largaespada; Andrew J Mungall; Richard A Moore; Nada Jabado; Gary D Bader; Steven J M Jones; David Malkin; Marco A Marra; Michael D Taylor
Journal: Nature Date: 2016-01-13 Impact factor: 49.962

6. Upregulated expression of DIXDC1 in intestinal-type gastric carcinoma: co-localization with β-catenin and correlation with poor prognosis.

Authors: Lei Wang; Cong Tan; Fan Qiao; Weige Wang; Xiangnan Jiang; Peng Lian; Bin Chang; Weiqi Sheng
Journal: Cancer Cell Int Date: 2015-12-18 Impact factor: 5.722

7. MicroRNA-1225-5p inhibits proliferation and metastasis of gastric carcinoma through repressing insulin receptor substrate-1 and activation of β-catenin signaling.

Authors: Haiyin Zheng; Fuxing Zhang; Xinjian Lin; Changming Huang; Yiqin Zhang; Yun Li; Jianyin Lin; Wannan Chen; Xu Lin
Journal: Oncotarget Date: 2016-01-26

8. Direct regulation of transforming growth factor β-induced epithelial-mesenchymal transition by the protein phosphatase activity of unphosphorylated PTEN in lung cancer cells.

Authors: Masaaki Kusunose; Naozumi Hashimoto; Motohiro Kimura; Ryo Ogata; Daisuke Aoyama; Koji Sakamoto; Shinichi Miyazaki; Akira Ando; Norihito Omote; Kazuyoshi Imaizumi; Tsutomu Kawabe; Yoshinori Hasegawa
Journal: Cancer Sci Date: 2015-11-06 Impact factor: 6.716

Regulation of CTNNB1 signaling in gastric cancer and stem cells.

1. Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling.

2. SDF-1/CXCR4 promotes epithelial-mesenchymal transition and progression of colorectal cancer by activation of the Wnt/β-catenin signaling pathway.

3. Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions.

4. Identification of c-MYC as a target of the APC pathway.

5. Divergent clonal selection dominates medulloblastoma at recurrence.

6. Upregulated expression of DIXDC1 in intestinal-type gastric carcinoma: co-localization with β-catenin and correlation with poor prognosis.

7. MicroRNA-1225-5p inhibits proliferation and metastasis of gastric carcinoma through repressing insulin receptor substrate-1 and activation of β-catenin signaling.

8. Direct regulation of transforming growth factor β-induced epithelial-mesenchymal transition by the protein phosphatase activity of unphosphorylated PTEN in lung cancer cells.

9. Notch and Wnt/β-catenin signaling pathway play important roles in activating liver cancer stem cells.

Review 10. Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis.

Review 1. Regulatory RNAs, microRNA, long-non coding RNA and circular RNA roles in colorectal cancer stem cells.

2. Rottlerin as a novel chemotherapy agent for adrenocortical carcinoma.

3. Knockdown of PNO1 inhibits esophageal cancer progression.