Francesco Ferrara1, Lawrence G Rudski2, Olga Vriz3, Luna Gargani4, Jonathan Afilalo2, Antonello D'Andrea5, Michele D'Alto5, Alberto M Marra6, Edvige Acri7, Anna Agnese Stanziola8, Stefano Ghio9, Antonio Cittadini10, Robert Naeije11, Eduardo Bossone12. 1. Cardiology Division, "Cava de' Tirreni and Amalfi Coast" Hospital, Heart Department, University Hospital of Salerno, Salerno, Italy. 2. Jewish General Hospital, McGill University, Montreal, Quebec, Canada. 3. Hospital of San Daniele del Friuli, Cardiology and Emergency Department, Udine, Italy. 4. Institute of Clinical Physiology - C.N.R., Pisa, Italy. 5. Second University of Naples, Department of Cardiology, Napoli, Italy. 6. IRCCS S.D.N., Naples, Italy. 7. Cardiology Division, University of Messina, Italy. 8. Department of Respiratory Diseases, Monaldi Hospital, University "Federico II", Naples, Italy. 9. Cardiology Division, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. 10. Department of Translational Medical Sciences, University Federico II of Naples, Naples, Italy. 11. Free University of Brussels, Brussels, Belgium. 12. Cardiology Division, "Cava de' Tirreni and Amalfi Coast" Hospital, Heart Department, University Hospital of Salerno, Salerno, Italy. Electronic address: ebossone@hotmail.com.
Abstract
BACKGROUND: TAPSE provides a simple, reproducible estimate of the longitudinal function of the right ventricle (RV). However, the normal limits and physiologic correlates of tricuspid annular plane systolic excursion (TAPSE) are not exactly known. The aim of this study was to explore the full spectrum of TAPSE values and determine the physiologic correlates of TAPSE. METHODS AND RESULTS: From June 2007 to December 2013, 1168 healthy subjects [mean age 45.1±16years, range 16 to 92; 555 (47.5%) men] underwent comprehensive transthoracic echocardiography (TTE) as recommended by current guidelines. TAPSE values were higher in men than women (24.0±3.5 vs 23.2±3.0mm, p value<0.0001) but did not vary according to age. On multivariable linear regression analysis, cardiac output, RV basal and longitudinal dimensions were the only variables independently associated with TAPSE (β coefficient=0.161, 0.116 and 0.115 respectively). On the other hand echocardiographically-derived systolic pulmonary artery pressure (SPAP), pulmonary vascular resistance and mitral E/e' ratio were significantly higher in older subjects. Therefore a significant decrease of TAPSE/SPAP was detected in >60years old cohort (p=0.0001). CONCLUSIONS: Our large cohort of healthy subjects provides sex and age-based TAPSE and TAPSE/SPAP normal cut-offs. TAPSE was found to be higher in men but not influenced by age. It was mainly correlated with echo-Doppler indices reflecting pre-load as opposed to afterload. On the other hand a significant decrease of TAPSE/SPAP with older age was registered as a direct consequence of increased SPAP with aging.
BACKGROUND: TAPSE provides a simple, reproducible estimate of the longitudinal function of the right ventricle (RV). However, the normal limits and physiologic correlates of tricuspid annular plane systolic excursion (TAPSE) are not exactly known. The aim of this study was to explore the full spectrum of TAPSE values and determine the physiologic correlates of TAPSE. METHODS AND RESULTS: From June 2007 to December 2013, 1168 healthy subjects [mean age 45.1±16years, range 16 to 92; 555 (47.5%) men] underwent comprehensive transthoracic echocardiography (TTE) as recommended by current guidelines. TAPSE values were higher in men than women (24.0±3.5 vs 23.2±3.0mm, p value<0.0001) but did not vary according to age. On multivariable linear regression analysis, cardiac output, RV basal and longitudinal dimensions were the only variables independently associated with TAPSE (β coefficient=0.161, 0.116 and 0.115 respectively). On the other hand echocardiographically-derived systolic pulmonary artery pressure (SPAP), pulmonary vascular resistance and mitral E/e' ratio were significantly higher in older subjects. Therefore a significant decrease of TAPSE/SPAP was detected in >60years old cohort (p=0.0001). CONCLUSIONS: Our large cohort of healthy subjects provides sex and age-based TAPSE and TAPSE/SPAP normal cut-offs. TAPSE was found to be higher in men but not influenced by age. It was mainly correlated with echo-Doppler indices reflecting pre-load as opposed to afterload. On the other hand a significant decrease of TAPSE/SPAP with older age was registered as a direct consequence of increased SPAP with aging.
Authors: S Heyl; B Luu; M Wieszner; A Nikkhoo; F Seeger; K Hemmann; B Assmus; B Kaess; A M Zeiher; C Walther; S Fichtlscherer; J Honold Journal: Int J Cardiol Heart Vasc Date: 2020-10-12
Authors: Michele D'Alto; Alberto M Marra; Sergio Severino; Andrea Salzano; Emanuele Romeo; Rosanna De Rosa; Francesca Maria Stagnaro; Gianpiero Pagnano; Raffaele Verde; Patrizia Murino; Andrea Farro; Giovanni Ciccarelli; Maria Vargas; Giuseppe Fiorentino; Giuseppe Servillo; Ivan Gentile; Antonio Corcione; Antonio Cittadini; Robert Naeije; Paolo Golino Journal: Crit Care Date: 2020-11-30 Impact factor: 9.097
Authors: Olga Vriz; Paolo Palatini; Lawrence Rudski; Paolo Frumento; Jarosław D Kasprzak; Francesco Ferrara; Rosangela Cocchia; Luna Gargani; Karina Wierzbowska-Drabik; Valentina Capone; Brigida Ranieri; Andrea Salzano; Anna Agnese Stanziola; Alberto Maria Marra; Roberto Annunziata; Salvatore Chianese; Salvatore Rega; Teresa Saltalamacchia; Renato Maramaldi; Chiara Sepe; Giuseppe Limongelli; Filippo Cademartiri; Antonello D'Andrea; Michele D'Alto; Raffaele Izzo; Nicola Ferrara; Ciro Mauro; Antonio Cittadini; Grünig Ekkehard; Marco Guazzi; Eduardo Bossone Journal: J Clin Med Date: 2022-01-17 Impact factor: 4.241