Literature DB >> 27572415

Complex Class 1 Integron Carrying qnrB62 and blaVIM-2 in a Citrobacter freundii Clinical Isolate.

Jae Jin Lee1, Mi-Na Kim2, Kwang Seung Park1, Jung Hun Lee1, Asad Mustafa Karim1, Moonhee Park1,3, Ji Hwan Kim1, Sang Hee Lee4.   

Abstract

The coexistence of qnrB62 and blaVIM-2 was detected in a Citrobacter clinical isolate. The reduced fluoroquinolone susceptibility is attributable to qnrB62, mutations of quinolone-resistance-determining regions, and an efflux pump or pumps. The genetic context surrounding chromosomal qnrB62 was a novel complex class 1 integron (In1184::ISCR1::qnrB62) containing a unique gene array (blaVIM-2-aacA4'-8-gucD). An 18-nucleotide deletion at the 3' end of the pspA gene [pspA(Δ18)], upstream of qnrB62, and an inverted repeat region (IRR2) were detected in In1184::ISCR1::qnrB62, indicating past transposition events.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 27572415      PMCID： PMC5075112          DOI： 10.1128/AAC.00614-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii.

Authors:  Il Kwon Bae; Indal Park; Jae Jin Lee; Ha Ik Sun; Kwang Seung Park; Jeong Eun Lee; Ji Hye Ahn; Sang Hee Lee; Gun-Jo Woo
Journal:  Antimicrob Agents Chemother       Date:  2010-04-26       Impact factor: 5.191

2.  Urgent need for β-lactam-β-lactamase inhibitors.

Authors:  Jung Hun Lee; Jae Jin Lee; Kwang Seung Park; Sang Hee Lee
Journal:  Lancet Infect Dis       Date:  2015-07-19       Impact factor: 25.071

3.  Novel variant of the qnrB gene, qnrB12, in Citrobacter werkmanii.

Authors:  Corinna Kehrenberg; Sonja Friederichs; Anno de Jong; Stefan Schwarz
Journal:  Antimicrob Agents Chemother       Date:  2007-12-17       Impact factor: 5.191

4.  Gene splicing and mutagenesis by PCR-driven overlap extension.

Authors:  Karin L Heckman; Larry R Pease
Journal:  Nat Protoc       Date:  2007       Impact factor: 13.491

5.  Isolation of novel IncA/C and IncN fluoroquinolone resistance plasmids from an antibiotic-polluted lake.

Authors:  Carl-Fredrik Flach; Anna Johnning; Ida Nilsson; Kornelia Smalla; Erik Kristiansson; D G Joakim Larsson
Journal:  J Antimicrob Chemother       Date:  2015-06-29       Impact factor: 5.790

6.  The KQ element, a complex genetic region conferring transferable resistance to carbapenems, aminoglycosides, and fluoroquinolones in Klebsiella pneumoniae.

Authors:  Louis B Rice; Lenore L Carias; Rebecca A Hutton; Susan D Rudin; Andrea Endimiani; Robert A Bonomo
Journal:  Antimicrob Agents Chemother       Date:  2008-06-23       Impact factor: 5.191

Review 7.  Plasmid-mediated quinolone resistance: a multifaceted threat.

Authors:  Jacob Strahilevitz; George A Jacoby; David C Hooper; Ari Robicsek
Journal:  Clin Microbiol Rev       Date:  2009-10       Impact factor: 26.132

8.  ISEcp1-mediated transposition of qnrB-like gene in Escherichia coli.

Authors:  Vincent Cattoir; Patrice Nordmann; Jesus Silva-Sanchez; Paula Espinal; Laurent Poirel
Journal:  Antimicrob Agents Chemother       Date:  2008-06-02       Impact factor: 5.191

Review 9.  Plasmid encoded antibiotic resistance: acquisition and transfer of antibiotic resistance genes in bacteria.

Authors:  P M Bennett
Journal:  Br J Pharmacol       Date:  2008-01-14       Impact factor: 8.739

10.  Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

Authors:  Yolanda Sáenz; Myriam Zarazaga; Laura Briñas; Fernanda Ruiz-Larrea; Carmen Torres
Journal:  J Antimicrob Chemother       Date:  2003-03-13       Impact factor: 5.790
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  4 in total

Review 1.  Transferable Mechanisms of Quinolone Resistance from 1998 Onward.

Authors:  Joaquim Ruiz
Journal:  Clin Microbiol Rev       Date:  2019-08-14       Impact factor: 26.132

2.  A comprehensive survey of integron-associated genes present in metagenomes.

Authors:  Mariana Buongermino Pereira; Tobias Österlund; K Martin Eriksson; Thomas Backhaus; Marina Axelson-Fisk; Erik Kristiansson
Journal:  BMC Genomics       Date:  2020-07-20       Impact factor: 3.969

3.  Characterization of a Novel Variant of the Quinolone-Resistance Gene qnrB (qnrB89) Carried by a Multi-Drug Resistant Citrobacter gillenii Strain Isolated from Farmed Salmon in Chile.

Authors:  Christopher Concha; Claudio D Miranda; Rodrigo Rojas; Felix A Godoy; Jaime Romero
Journal:  Antibiotics (Basel)       Date:  2021-02-26

4.  Detection of common mobile genetic elements and genotyping of multidrug-resistant Gram-negative bacilli in blood specimens from septicemia patients in southern China.

Authors:  Yongyu Rui; Wengting Lu; Si Li; Cancan Cheng; Jingjing Sun; Qiu Yang
Journal:  Infect Drug Resist       Date:  2018-10-12       Impact factor: 4.003
  4 in total

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