Feon W Cheng1, Xiang Gao2, Diane C Mitchell1, Craig Wood3, Christopher D Still3, David Rolston3, Gordon L Jensen1,4. 1. Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania, USA. 2. Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania, USA. xxg14@psu.edu. 3. Department of Internal Medicine & the Obesity Institute, Geisinger Health System, Danville, Pennsylvania, USA. 4. Dean's Office and Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA.
Abstract
OBJECTIVE: To examine the association between baseline body mass index (BMI, kg/m(2) ) and all-cause mortality in a well-characterized cohort of older persons. METHODS: The association between BMI (both as a categorical and continuous variable) and all-cause mortality was investigated using 4,565 Geisinger Rural Aging Study participants with baseline age 74.0 ± 4.7 years (mean ± SD) and BMI 29.5 ± 5.3 kg/m(2) over a mean of 10.9 ± 3.8 years of follow-up. RESULTS: The relationship between BMI (as a continuous variable) and all-cause mortality was found to be U-shaped (P nonlinearity <0.001). Controlling for age, sex, smoking, alcohol, laboratory values, medications, and comorbidity status, underweight (BMI <18.5 kg/m(2) ) individuals had significantly greater adjusted risk of all-cause mortality than persons of BMI 18.5 to 24.9 kg/m(2) (reference range). Participants with overweight (BMI 25.0-29.9 kg/m(2) ) and class I obesity (BMI 30.0-34.9 kg/m(2) ) had significantly lower adjusted-risk of all-cause mortality. Those with classes II/III obesity (BMI ≥ 35.0 kg/m(2) ) did not have significantly greater adjusted-risk of all-cause mortality. Findings were consistent using propensity score weights and among never-smokers with 2- and 5-year lag analysis and among those with no identified chronic disease. CONCLUSIONS: A U-shaped association was observed between BMI and all-cause mortality with lower risk among older persons with overweight and class I obesity in comparison with those with BMI 18.5 to 24.9 kg/m(2) .
OBJECTIVE: To examine the association between baseline body mass index (BMI, kg/m(2) ) and all-cause mortality in a well-characterized cohort of older persons. METHODS: The association between BMI (both as a categorical and continuous variable) and all-cause mortality was investigated using 4,565 Geisinger Rural Aging Study participants with baseline age 74.0 ± 4.7 years (mean ± SD) and BMI 29.5 ± 5.3 kg/m(2) over a mean of 10.9 ± 3.8 years of follow-up. RESULTS: The relationship between BMI (as a continuous variable) and all-cause mortality was found to be U-shaped (P nonlinearity <0.001). Controlling for age, sex, smoking, alcohol, laboratory values, medications, and comorbidity status, underweight (BMI <18.5 kg/m(2) ) individuals had significantly greater adjusted risk of all-cause mortality than persons of BMI 18.5 to 24.9 kg/m(2) (reference range). Participants with overweight (BMI 25.0-29.9 kg/m(2) ) and class I obesity (BMI 30.0-34.9 kg/m(2) ) had significantly lower adjusted-risk of all-cause mortality. Those with classes II/III obesity (BMI ≥ 35.0 kg/m(2) ) did not have significantly greater adjusted-risk of all-cause mortality. Findings were consistent using propensity score weights and among never-smokers with 2- and 5-year lag analysis and among those with no identified chronic disease. CONCLUSIONS: A U-shaped association was observed between BMI and all-cause mortality with lower risk among older persons with overweight and class I obesity in comparison with those with BMI 18.5 to 24.9 kg/m(2) .
Authors: M de Almeida Roediger; M de Fátima Nunes Marucci; D A Quintiliano Scarpelli Dourado; C de Oliveira; J Licio Ferreira Santos; Y A de Oliveira Duarte Journal: J Nutr Health Aging Date: 2019 Impact factor: 4.075
Authors: Julie Shlisky; David E Bloom; Amy R Beaudreault; Katherine L Tucker; Heather H Keller; Yvonne Freund-Levi; Roger A Fielding; Feon W Cheng; Gordon L Jensen; Dayong Wu; Simin N Meydani Journal: Adv Nutr Date: 2017-01-17 Impact factor: 8.701
Authors: Yang Claire Yang; Christine E Walsh; Moira P Johnson; Daniel W Belsky; Max Reason; Patrick Curran; Allison E Aiello; Marianne Chanti-Ketterl; Kathleen Mullan Harris Journal: Proc Natl Acad Sci U S A Date: 2021-04-27 Impact factor: 11.205
Authors: Sheila M Manemann; Jennifer L St Sauver; Hongfang Liu; Nicholas B Larson; Sungrim Moon; Paul Y Takahashi; Janet E Olson; Walter A Rocca; Virginia M Miller; Terry M Therneau; Che G Ngufor; Veronique L Roger; Yiqing Zhao; Paul A Decker; Jill M Killian; Suzette J Bielinski Journal: BMJ Open Date: 2021-06-08 Impact factor: 3.006