| Literature DB >> 27569582 |
Qing-Hai Ye1, Wen-Wei Zhu2, Ju-Bo Zhang3, Yi Qin4, Ming Lu5, Guo-Ling Lin1, Lei Guo1, Bo Zhang1, Zhen-Hai Lin1, Stephanie Roessler6, Marshonna Forgues7, Hu-Liang Jia5, Lu Lu5, Xiao-Fei Zhang5, Bao-Feng Lian8, Lu Xie8, Qiong-Zhu Dong9, Zhao-You Tang2, Xin Wei Wang10, Lun-Xiu Qin11.
Abstract
The mechanism of cancer metastasis remains poorly understood. Using gene profiling of hepatocellular carcinoma (HCC) tissues, we have identified GOLM1 as a leading gene relating to HCC metastasis. GOLM1 expression is correlated with early recurrence, metastasis, and poor survival of HCC patients. Both gain- and loss-of-function studies determine that GOLM1 acts as a key oncogene by promoting HCC growth and metastasis. It selectively interacts with epidermal growth factor receptor (EGFR) and serves as a specific cargo adaptor to assist EGFR/RTK anchoring on the trans-Golgi network (TGN) and recycling back to the plasma membrane, leading to prolonged activation of the downstream kinases. These findings reveal the functional role of GOLM1, a Golgi-related protein, in EGFR/RTK recycling and metastatic progression of HCC.Entities:
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Year: 2016 PMID： 27569582 PMCID： PMC5021625 DOI： 10.1016/j.ccell.2016.07.017
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743