Literature DB >> 25634214

GOLPH3 links the Golgi, DNA damage, and cancer.

Matthew D Buschman1, Juliati Rahajeng1, Seth J Field2.   

Abstract

GOLPH3 is the first example of an oncogene that functions in secretory trafficking at the Golgi. The discovery of GOLPH3's roles in both cancer and Golgi trafficking raises questions about how GOLPH3 and the Golgi contribute to cancer. Our recent investigation of the regulation of GOLPH3 revealed a surprising response by the Golgi upon DNA damage that is mediated by DNA-PK and GOLPH3. These results provide new insight into the DNA damage response with important implications for understanding the cellular response to standard cancer therapeutic agents. ©2015 American Association for Cancer Research.

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Year:  2015        PMID： 25634214      PMCID： PMC4333064          DOI： 10.1158/0008-5472.CAN-14-3081

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  42 in total

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Journal:  J Biol Chem       Date:  1999-11-26       Impact factor: 5.157

5.  Substrate specificities and identification of putative substrates of ATM kinase family members.

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Journal:  J Biol Chem       Date:  1999-12-31       Impact factor: 5.157

6.  Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi.

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Journal:  Cell       Date:  2003-08-08       Impact factor: 41.582

Review 7.  Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining.

Authors:  Brandi L Mahaney; Katheryn Meek; Susan P Lees-Miller
Journal:  Biochem J       Date:  2009-02-01       Impact factor: 3.857

8.  PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival.

Authors:  Lana Bozulic; Banu Surucu; Debby Hynx; Brian A Hemmings
Journal:  Mol Cell       Date:  2008-04-25       Impact factor: 17.970

9.  FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P.

Authors:  Anna Godi; Antonella Di Campli; Athanasios Konstantakopoulos; Giuseppe Di Tullio; Dario R Alessi; Gursant S Kular; Tiziana Daniele; Pierfrancesco Marra; John M Lucocq; M Antonietta De Matteis
Journal:  Nat Cell Biol       Date:  2004-04-25       Impact factor: 28.824

10.  Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1.

Authors:  Anastasia Blagoveshchenskaya; Fei Ying Cheong; Holger M Rohde; Greta Glover; Andreas Knödler; Teresa Nicolson; Guido Boehmelt; Peter Mayinger
Journal:  J Cell Biol       Date:  2008-02-25       Impact factor: 10.539
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  35 in total

Review 1.  Proteomics Identifies Golgi phosphoprotein 3 (GOLPH3) with A Link Between Golgi Structure, Cancer, DNA Damage and Protection from Cell Death.

Authors:  John J M Bergeron; Catherine E Au; David Y Thomas; Louis Hermo
Journal:  Mol Cell Proteomics       Date:  2017-09-27       Impact factor: 5.911

2.  [Golgi phosphoprotein 3 overexpression inhibits paclitaxel-induced apoptosis in HeLa cells by promoting autophagy].

Authors:  Zhennan Wang; Yuhan Zheng; Haili Huang; Huijuan He; Qingming Jia
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2019-11-30

Review 3.  GOLPH3: a Golgi phosphatidylinositol(4)phosphate effector that directs vesicle trafficking and drives cancer.

Authors:  Ramya S Kuna; Seth J Field
Journal:  J Lipid Res       Date:  2018-09-28       Impact factor: 5.922

Review 4.  Emerging themes of regulation at the Golgi.

Authors:  Stefanie L Makowski; Thuy Tt Tran; Seth J Field
Journal:  Curr Opin Cell Biol       Date:  2017-02-16       Impact factor: 8.382

Review 5.  MYO18A: An unusual myosin.

Authors:  Matthew D Buschman; Seth J Field
Journal:  Adv Biol Regul       Date:  2017-09-18

6.  Wiskott-Aldrich syndrome protein senses irradiation-induced DNA damage to coordinate the cell-protective Golgi dispersal response in human T and B lymphocytes.

Authors:  Kuo-Kuang Wen; Seong-Su Han; Yatin M Vyas
Journal:  J Allergy Clin Immunol       Date:  2019-10-09       Impact factor: 10.793

7.  GOLM1 Modulates EGFR/RTK Cell-Surface Recycling to Drive Hepatocellular Carcinoma Metastasis.

Authors:  Qing-Hai Ye; Wen-Wei Zhu; Ju-Bo Zhang; Yi Qin; Ming Lu; Guo-Ling Lin; Lei Guo; Bo Zhang; Zhen-Hai Lin; Stephanie Roessler; Marshonna Forgues; Hu-Liang Jia; Lu Lu; Xiao-Fei Zhang; Bao-Feng Lian; Lu Xie; Qiong-Zhu Dong; Zhao-You Tang; Xin Wei Wang; Lun-Xiu Qin
Journal:  Cancer Cell       Date:  2016-08-25       Impact factor: 31.743

8.  Correlational research of Golgi phosphorylation protein 3 expression in colorectal cancer.

Authors:  Yan-Ta Guo; Cheng-Zhi Qiu; Zhong-Xin Huang; Wai-Shi Yu; Xiao-Feng Yang; Ming-Zhen Wang
Journal:  World J Gastroenterol       Date:  2015-12-28       Impact factor: 5.742

9.  Copy number analysis of whole-genome data using BIC-seq2 and its application to detection of cancer susceptibility variants.

Authors:  Ruibin Xi; Semin Lee; Yuchao Xia; Tae-Min Kim; Peter J Park
Journal:  Nucleic Acids Res       Date:  2016-06-03       Impact factor: 16.971

10.  Inhibition of glioma growth by a GOLPH3 siRNA-loaded cationic liposomes.

Authors:  Zixuan Yuan; Liang Zhao; Yafei Zhang; Shun Li; Bomin Pan; Lei Hua; Zhen Wang; Chengkun Ye; Jun Lu; Rutong Yu; Hongmei Liu
Journal:  J Neurooncol       Date:  2018-08-13       Impact factor: 4.130
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