Florian Rüfer1, Julia Jasmin Bartsch2, Carl Erb3, Anneliese Riehl4, Philipp Franko Zeitz5. 1. nordBLICK Eye Clinic Bellevue, Lindenallee 21/23, 24105, Kiel, Germany. f.ruefer@nordblick.de. 2. University of Münster Medical Center, Domagkstrasse 15, 48149, Münster, Germany. 3. Eye Clinic Wittenbergplatz, Kleiststr. 23-26, 10787, Berlin, Germany. 4. nordBLICK Eye Clinic Bellevue, Lindenallee 21/23, 24105, Kiel, Germany. 5. Practice Zeitz Franko Zeitz, Blumenstrasse 11-15, 40212, Düsseldorf, Germany.
Abstract
PURPOSE: We aimed to examine the extent to which measurement errors in the determination of retinal nerve fibre layer (RNFL) using spectral-domain optical coherence tomography (SD-OCT) occur in cases of epiretinal membrane and whether systematic deviations are found in the values obtained. METHODS: A macular scan and a circumpapillary scan were performed on 97 eyes of 97 patients using SD-OCT. Group 1 comprised 53 patients with epiretinal membrane at an age of 70 ± 4.8 years (median ± average absolute deviation). Group 2 consisted of 44 patients without any macular pathologies (median age 70 ± 5.8 years). Differences in the thickness of the RNFL and segmentation errors in the detection of the RNFL were recorded quantitatively in both groups and checked for statistical significance using non-parametric tests. RESULTS: The median central retinal thickness in Group 1 was 357 ± 79 μm (median ± average absolute deviation), and in Group 2 it was 270 ± 11 μm (p < 0.001). The result of the quadrant-by-quadrant measurement of the average RNFL in Group 1 and Group 2, respectively, was: temporal 88 ± 17 and 73 ± 9 μm, inferior 121 ± 17 and 118 ± 15 μm, nasal 87 ± 15 and 89 ± 14 μm and superior 115 ± 15 and 114 ± 9 μm. Temporally, the difference was statistically significant (p < 0.001). Segmentation errors of the RNFL were found in 19 of 53 eyes (35.8 %) in Group 1 and in no eyes (p < 0.001) in Group 2. CONCLUSIONS: In eyes with epiretinal membrane, measuring errors in the SD-OCT occur significantly more frequently than in eyes without any retinal pathologies. If epiretinal membrane and glaucoma are present simultaneously, the results of the automated RNFL measurement using SD-OCT should be critically scrutinised, even if no papillary changes are visible clinically.
PURPOSE: We aimed to examine the extent to which measurement errors in the determination of retinal nerve fibre layer (RNFL) using spectral-domain optical coherence tomography (SD-OCT) occur in cases of epiretinal membrane and whether systematic deviations are found in the values obtained. METHODS: A macular scan and a circumpapillary scan were performed on 97 eyes of 97 patients using SD-OCT. Group 1 comprised 53 patients with epiretinal membrane at an age of 70 ± 4.8 years (median ± average absolute deviation). Group 2 consisted of 44 patients without any macular pathologies (median age 70 ± 5.8 years). Differences in the thickness of the RNFL and segmentation errors in the detection of the RNFL were recorded quantitatively in both groups and checked for statistical significance using non-parametric tests. RESULTS: The median central retinal thickness in Group 1 was 357 ± 79 μm (median ± average absolute deviation), and in Group 2 it was 270 ± 11 μm (p < 0.001). The result of the quadrant-by-quadrant measurement of the average RNFL in Group 1 and Group 2, respectively, was: temporal 88 ± 17 and 73 ± 9 μm, inferior 121 ± 17 and 118 ± 15 μm, nasal 87 ± 15 and 89 ± 14 μm and superior 115 ± 15 and 114 ± 9 μm. Temporally, the difference was statistically significant (p < 0.001). Segmentation errors of the RNFL were found in 19 of 53 eyes (35.8 %) in Group 1 and in no eyes (p < 0.001) in Group 2. CONCLUSIONS: In eyes with epiretinal membrane, measuring errors in the SD-OCT occur significantly more frequently than in eyes without any retinal pathologies. If epiretinal membrane and glaucoma are present simultaneously, the results of the automated RNFL measurement using SD-OCT should be critically scrutinised, even if no papillary changes are visible clinically.
Authors: J Dawczynski; S Janz; M Kasper; S Franke; E Königsdörffer; R Augsten; J Strobel Journal: Klin Monbl Augenheilkd Date: 2006-08 Impact factor: 0.700
Authors: Maria A Mavrommatis; Nicole De Cuir; Juan Reynaud; Carlos G De Moraes; Daiyan Xin; Rashmi Rajshekhar; Jeffrey M Liebmann; Robert Ritch; Brad Fortune; Donald C Hood Journal: J Glaucoma Date: 2019-03 Impact factor: 2.503
Authors: Marco Rocco Pastore; Riccardo Merli; Carmen Dell'Aquila; Lorenzo Belfanti; Marco Franzon; Gabriella Cirigliano; Chiara De Giacinto; Rosa Giglio; Daniele Tognetto Journal: Diagnostics (Basel) Date: 2021-11-26