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Literature DB >> 27565924

Drug-induced myocarditis after nivolumab treatment in a patient with PDL1- negative squamous cell carcinoma of the lung.

H Semper¹, F Muehlberg², J Schulz-Menger², M Allewelt¹, C Grohé³.

Abstract

Immunotherapy such as nivolumab is a new promising therapeutic option for advanced stage non small cell lung cancer (NSCLC). Due to the interference with the immune system previously unknown side effects are observed both in clinical studies and experience. Autoimmune phenomena effecting skin, gastrointestinal tract, endocrine glands, kidney and lung have been described. Up to now there is only limited information regarding potential cardiac side effects. We present a case of symptomatic drug induced myocarditis after nine cycles of nivolumab in a patient with efficient anticancer response.

Entities: Chemical Disease Gene Species

Keywords: Drug-induced myocarditis; Immunotherapy; Nivolumab; PDL-1; Pulmonary squamous cell carcinoma

Mesh：

Substances：

Year: 2016 PMID： 27565924 DOI： 10.1016/j.lungcan.2016.06.025

Source DB: PubMed Journal: Lung Cancer ISSN： 0169-5002 Impact factor: 5.705

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Cited

33 in total

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Review 3. Checkpoint Inhibitors.

Authors: Lucie Heinzerling; Enrico N de Toni; Georg Schett; Gheorghe Hundorfean; Lisa Zimmer
Journal: Dtsch Arztebl Int Date: 2019-02-22 Impact factor: 5.594

Review 4. Pediatric Cardio-Oncology: Development of Cancer Treatment-Related Cardiotoxicity and the Therapeutic Approach to Affected Patients.

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Journal: Curr Treat Options Oncol Date: 2019-05-25

Drug-induced myocarditis after nivolumab treatment in a patient with PDL1- negative squamous cell carcinoma of the lung.

Review 1. Cardiovascular Complications Associated With Novel Cancer Immunotherapies.

2. Immune Checkpoint Inhibitor-Related Cardiotoxicity.

Review 3. Checkpoint Inhibitors.

Review 4. Pediatric Cardio-Oncology: Development of Cancer Treatment-Related Cardiotoxicity and the Therapeutic Approach to Affected Patients.

Review 5. Co-stimulatory and co-inhibitory pathways in cancer immunotherapy.

Review 6. Human In Vitro Models for Assessing the Genomic Basis of Chemotherapy-Induced Cardiovascular Toxicity.

7. [Lymphocytic myocarditis in a patient with metastatic clear cell renal cell carcinoma treated with Nivolumab].

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Review 10. Hodgkin lymphoma: A review and update on recent progress.