Literature DB >> 28819833

[Lymphocytic myocarditis in a patient with metastatic clear cell renal cell carcinoma treated with Nivolumab].

R Sauer1, P Kiewe2, M Desole3, M Schuler3, F Theissig4, A Roth4, T Mairinger4.   

Abstract

Immune checkpoint inhibitors against the PD-1 protein offer a new therapy option for many solid cancers. We report a patient with metastatic renal cell cancer treated with Nivolumab. As a rare immune-mediated adverse event, we describe a fatal lymphocytic myocarditis two weeks after starting immune therapy. The cause of death was first diagnosed at autopsy. This case report underlines the importance and need of clinical autopsies as an instrument of quality assurance and detection of rare therapy-induced adverse effects.

Entities:  

Keywords:  Immune-mediated adverse event; Lymphocytic myocarditis; PD-1 inhibition; Parvovirus B19; Renal cell carcinoma

Mesh:

Substances:

Year:  2017        PMID: 28819833     DOI: 10.1007/s00292-017-0349-y

Source DB:  PubMed          Journal:  Pathologe        ISSN: 0172-8113            Impact factor:   1.011


  26 in total

Review 1.  [The pathology of adverse events with immune checkpoint inhibitors].

Authors:  V H Koelzer; K Glatz; L Bubendorf; A Weber; A Gaspert; G Cathomas; A Lugli; A Zippelius; W Kempf; K D Mertz
Journal:  Pathologe       Date:  2017-05       Impact factor: 1.011

Review 2.  Current Perspectives in Immunotherapy for Non-Small Cell Lung Cancer.

Authors:  Edward B Garon
Journal:  Semin Oncol       Date:  2015-09-11       Impact factor: 4.929

Review 3.  Relevance of cardiac parvovirus B19 in myocarditis and dilated cardiomyopathy: review of the literature.

Authors:  Job Verdonschot; Mark Hazebroek; Jort Merken; Yannick Debing; Robert Dennert; Hans-Peter Brunner-La Rocca; Stephane Heymans
Journal:  Eur J Heart Fail       Date:  2016-10-17       Impact factor: 15.534

Review 4.  Immune checkpoint blockade: a common denominator approach to cancer therapy.

Authors:  Suzanne L Topalian; Charles G Drake; Drew M Pardoll
Journal:  Cancer Cell       Date:  2015-04-06       Impact factor: 31.743

5.  Overall Survival and Long-Term Safety of Nivolumab (Anti-Programmed Death 1 Antibody, BMS-936558, ONO-4538) in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer.

Authors:  Scott N Gettinger; Leora Horn; Leena Gandhi; David R Spigel; Scott J Antonia; Naiyer A Rizvi; John D Powderly; Rebecca S Heist; Richard D Carvajal; David M Jackman; Lecia V Sequist; David C Smith; Philip Leming; David P Carbone; Mary C Pinder-Schenck; Suzanne L Topalian; F Stephen Hodi; Jeffrey A Sosman; Mario Sznol; David F McDermott; Drew M Pardoll; Vindira Sankar; Christoph M Ahlers; Mark Salvati; Jon M Wigginton; Matthew D Hellmann; Georgia D Kollia; Ashok K Gupta; Julie R Brahmer
Journal:  J Clin Oncol       Date:  2015-04-20       Impact factor: 44.544

6.  Survival, Durable Response, and Long-Term Safety in Patients With Previously Treated Advanced Renal Cell Carcinoma Receiving Nivolumab.

Authors:  David F McDermott; Charles G Drake; Mario Sznol; Toni K Choueiri; John D Powderly; David C Smith; Julie R Brahmer; Richard D Carvajal; Hans J Hammers; Igor Puzanov; F Stephen Hodi; Harriet M Kluger; Suzanne L Topalian; Drew M Pardoll; Jon M Wigginton; Georgia D Kollia; Ashok Gupta; Dan McDonald; Vindira Sankar; Jeffrey A Sosman; Michael B Atkins
Journal:  J Clin Oncol       Date:  2015-03-30       Impact factor: 44.544

7.  PD-1 protects against inflammation and myocyte damage in T cell-mediated myocarditis.

Authors:  Margarite L Tarrio; Nir Grabie; De-xiu Bu; Arlene H Sharpe; Andrew H Lichtman
Journal:  J Immunol       Date:  2012-04-09       Impact factor: 5.422

8.  Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.

Authors:  Suzanne L Topalian; F Stephen Hodi; Julie R Brahmer; Scott N Gettinger; David C Smith; David F McDermott; John D Powderly; Richard D Carvajal; Jeffrey A Sosman; Michael B Atkins; Philip D Leming; David R Spigel; Scott J Antonia; Leora Horn; Charles G Drake; Drew M Pardoll; Lieping Chen; William H Sharfman; Robert A Anders; Janis M Taube; Tracee L McMiller; Haiying Xu; Alan J Korman; Maria Jure-Kunkel; Shruti Agrawal; Daniel McDonald; Georgia D Kollia; Ashok Gupta; Jon M Wigginton; Mario Sznol
Journal:  N Engl J Med       Date:  2012-06-02       Impact factor: 91.245

9.  Suspected autoimmune myocarditis and cardiac conduction abnormalities with nivolumab therapy for non-small cell lung cancer.

Authors:  Robert Gibson; Jess Delaune; Anita Szady; Merry Markham
Journal:  BMJ Case Rep       Date:  2016-07-20

10.  Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice.

Authors:  Julie A Lucas; Julia Menke; Whitney A Rabacal; Frederick J Schoen; Arlene H Sharpe; Vicki R Kelley
Journal:  J Immunol       Date:  2008-08-15       Impact factor: 5.422

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  2 in total

Review 1.  Cardiac toxicity of immune-checkpoint inhibitors: a clinical case of nivolumab-induced myocarditis and review of the evidence and new challenges.

Authors:  Roberto Martin Huertas; Cristina Saavedra Serrano; Cristian Perna; Ana Ferrer Gómez; Teresa Alonso Gordoa
Journal:  Cancer Manag Res       Date:  2019-05-16       Impact factor: 3.989

2.  Neural Net Modeling of Checkpoint Inhibitor Related Myocarditis and Steroid Response.

Authors:  Filip Stefanovic; Andres Gomez-Caminero; David M Jacobs; Poornima Subramanian; Igor Puzanov; Maya R Chilbert; Steven G Feuerstein; Yan Yatsynovich; Benjamin Switzer; Jerome J Schentag
Journal:  Clin Pharmacol       Date:  2022-08-10
  2 in total

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