| Literature DB >> 28819833 |
R Sauer1, P Kiewe2, M Desole3, M Schuler3, F Theissig4, A Roth4, T Mairinger4.
Abstract
Immune checkpoint inhibitors against the PD-1 protein offer a new therapy option for many solid cancers. We report a patient with metastatic renal cell cancer treated with Nivolumab. As a rare immune-mediated adverse event, we describe a fatal lymphocytic myocarditis two weeks after starting immune therapy. The cause of death was first diagnosed at autopsy. This case report underlines the importance and need of clinical autopsies as an instrument of quality assurance and detection of rare therapy-induced adverse effects.Entities:
Keywords: Immune-mediated adverse event; Lymphocytic myocarditis; PD-1 inhibition; Parvovirus B19; Renal cell carcinoma
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Year: 2017 PMID: 28819833 DOI: 10.1007/s00292-017-0349-y
Source DB: PubMed Journal: Pathologe ISSN: 0172-8113 Impact factor: 1.011