Literature DB >> 27562463

The interplay between cell signalling and the mevalonate pathway in cancer.

Peter J Mullen1, Rosemary Yu1,2, Joseph Longo1,2, Michael C Archer2,3, Linda Z Penn1,2.   

Abstract

The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to produce sterols and isoprenoids that are integral to tumour growth and progression. In recent years, many oncogenic signalling pathways have been shown to increase the activity and/or the expression of MVA pathway enzymes. This Review summarizes recent advances and discusses unique opportunities for immediately targeting this metabolic vulnerability in cancer with agents that have been approved for other therapeutic uses, such as the statin family of drugs, to improve outcomes for cancer patients.

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Year:  2016        PMID： 27562463     DOI： 10.1038/nrc.2016.76

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  202 in total

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Authors:  A J Wiemer; D F Wiemer; R J Hohl
Journal:  Clin Pharmacol Ther       Date:  2011-11-02       Impact factor: 6.875

2.  Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer.

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Journal:  Cancer Res       Date:  2007-08-01       Impact factor: 12.701

Review 3.  Regulation of the mevalonate pathway.

Authors:  J L Goldstein; M S Brown
Journal:  Nature       Date:  1990-02-01       Impact factor: 49.962

4.  Effect of zoledronic acid on disseminated tumour cells in women with locally advanced breast cancer: an open label, randomised, phase 2 trial.

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Journal:  Lancet Oncol       Date:  2010-03-31       Impact factor: 41.316

5.  Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7).

Authors:  Anders Sundqvist; Maria T Bengoechea-Alonso; Xin Ye; Vasyl Lukiyanchuk; Jianping Jin; J Wade Harper; Johan Ericsson
Journal:  Cell Metab       Date:  2005-06       Impact factor: 27.287

Review 6.  Enzymes of the mevalonate pathway of isoprenoid biosynthesis.

Authors:  Henry M Miziorko
Journal:  Arch Biochem Biophys       Date:  2010-10-07       Impact factor: 4.013

7.  Comparative safety of cardiovascular medication use and breast cancer outcomes among women with early stage breast cancer.

Authors:  Denise M Boudreau; Onchee Yu; Jessica Chubak; Heidi S Wirtz; Erin J Aiello Bowles; Monica Fujii; Diana S M Buist
Journal:  Breast Cancer Res Treat       Date:  2014-02-21       Impact factor: 4.872

Review 8.  Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR).

Authors:  Laura J Sharpe; Andrew J Brown
Journal:  J Biol Chem       Date:  2013-05-21       Impact factor: 5.157

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Authors:  Zachary T Schug; Barrie Peck; Dylan T Jones; Qifeng Zhang; Shaun Grosskurth; Israt S Alam; Louise M Goodwin; Elizabeth Smethurst; Susan Mason; Karen Blyth; Lynn McGarry; Daniel James; Emma Shanks; Gabriela Kalna; Rebecca E Saunders; Ming Jiang; Michael Howell; Francois Lassailly; May Zaw Thin; Bradley Spencer-Dene; Gordon Stamp; Niels J F van den Broek; Gillian Mackay; Vinay Bulusu; Jurre J Kamphorst; Saverio Tardito; David Strachan; Adrian L Harris; Eric O Aboagye; Susan E Critchlow; Michael J O Wakelam; Almut Schulze; Eyal Gottlieb
Journal:  Cancer Cell       Date:  2015-01-12       Impact factor: 31.743

10.  Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity.

Authors:  Vanessa P Houde; Maria Stella Ritorto; Robert Gourlay; Joby Varghese; Paul Davies; Natalia Shpiro; Kei Sakamoto; Dario R Alessi
Journal:  Biochem J       Date:  2014-02-15       Impact factor: 3.857
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  170 in total

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Authors:  Hannah M Jones; Ziwei Fang; Wenchuan Sun; Leslie H Clark; Jessica E Stine; Arthur-Quan Tran; Stephanie A Sullivan; Timothy P Gilliam; Chunxiao Zhou; Victoria L Bae-Jump
Journal:  Am J Cancer Res       Date:  2017-12-01       Impact factor: 6.166

2.  Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation.

Authors:  Ross A Weber; Frederick S Yen; Shirony P V Nicholson; Hanan Alwaseem; Erol C Bayraktar; Mohammad Alam; Rebecca C Timson; Konnor La; Monther Abu-Remaileh; Henrik Molina; Kıvanç Birsoy
Journal:  Mol Cell       Date:  2020-01-23       Impact factor: 17.970

Review 3.  The balance of protein farnesylation and geranylgeranylation during the progression of nonalcoholic fatty liver disease.

Authors:  Yue Zhao; Tian-Yu Wu; Meng-Fei Zhao; Chao-Jun Li
Journal:  J Biol Chem       Date:  2020-03-05       Impact factor: 5.157

4.  Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase.

Authors:  Ngee Kiat Chua; Gene Hart-Smith; Andrew J Brown
Journal:  J Biol Chem       Date:  2019-04-02       Impact factor: 5.157

5.  Statin use and pancreatic cancer risk in two prospective cohort studies.

Authors:  Tsuyoshi Hamada; Natalia Khalaf; Chen Yuan; Ana Babic; Vicente Morales-Oyarvide; Zhi Rong Qian; Jonathan Andrew Nowak; Kimmie Ng; Peter Kraft; Douglas Adam Rubinson; Meir Jonathan Stampfer; Edward Luciano Giovannucci; Charles Stewart Fuchs; Shuji Ogino; Brian Matthew Wolpin
Journal:  J Gastroenterol       Date:  2018-01-23       Impact factor: 7.527

6.  p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression.

Authors:  Sung-Hwan Moon; Chun-Hao Huang; Shauna L Houlihan; Kausik Regunath; William A Freed-Pastor; John P Morris; Darjus F Tschaharganeh; Edward R Kastenhuber; Anthony M Barsotti; Rachel Culp-Hill; Wen Xue; Yu-Jui Ho; Timour Baslan; Xiang Li; Allison Mayle; Elisa de Stanchina; Lars Zender; David R Tong; Angelo D'Alessandro; Scott W Lowe; Carol Prives
Journal:  Cell       Date:  2018-12-20       Impact factor: 41.582

7.  Cytotoxic effect of Semialarium mexicanum (Miers) Mennega root bark extracts and fractions against breast cancer cells.

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Journal:  Physiol Mol Biol Plants       Date:  2018-07-23

8.  Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells.

Authors:  Wei Su; Nicole M Chapman; Jun Wei; Hu Zeng; Yogesh Dhungana; Hao Shi; Jordy Saravia; Peipei Zhou; Lingyun Long; Sherri Rankin; Anil Kc; Peter Vogel; Hongbo Chi
Journal:  Cell Metab       Date:  2020-11-17       Impact factor: 27.287

9.  GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolism.

Authors:  Lisha Wei; Yan-Yan Zheng; Jie Sun; Pei Wang; Tao Tao; Yeqiong Li; Xin Chen; Yongjuan Sang; Danyang Chong; Wei Zhao; Yuwei Zhou; Ye Wang; Zhihui Jiang; Tiantian Qiu; Chao-Jun Li; Min-Sheng Zhu; Xuena Zhang
Journal:  J Biol Chem       Date:  2020-09-10       Impact factor: 5.157

Review 10.  The multifaceted roles of fatty acid synthesis in cancer.

Authors:  Florian Röhrig; Almut Schulze
Journal:  Nat Rev Cancer       Date:  2016-09-23       Impact factor: 60.716
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