Literature DB >> 27562461

The metabolic fate of acetate in cancer.

Zachary T Schug1,2, Johan Vande Voorde1, Eyal Gottlieb1.   

Abstract

Recent high-profile reports have reignited an interest in acetate metabolism in cancer. Acetyl-CoA synthetases that catalyse the conversion of acetate to acetyl-CoA have now been implicated in the growth of hepatocellular carcinoma, glioblastoma, breast cancer and prostate cancer. In this Review, we discuss how acetate functions as a nutritional source for tumours and as a regulator of cancer cell stress, and how preventing its (re)capture by cancer cells may provide an opportunity for therapeutic intervention.

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Year:  2016        PMID： 27562461      PMCID： PMC8992383          DOI： 10.1038/nrc.2016.87

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  119 in total

1.  Fatty acid metabolism. VIII. Acetate metabolism in vitro during hepatocarcinogenesis by p-dimethylaminoazobenzene.

Authors:  G MEDES; B FRIEDMANN; S WEINHOUSE
Journal:  Cancer Res       Date:  1956-01       Impact factor: 12.701

2.  Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress.

Authors:  Kathrin Zaugg; Yi Yao; Patrick T Reilly; Karuppiah Kannan; Reza Kiarash; Jacqueline Mason; Ping Huang; Suzanne K Sawyer; Benjamin Fuerth; Brandon Faubert; Tuula Kalliomäki; Andrew Elia; Xunyi Luo; Vincent Nadeem; David Bungard; Sireesha Yalavarthi; Joseph D Growney; Andrew Wakeham; Yasmin Moolani; Jennifer Silvester; Annick You Ten; Walbert Bakker; Katsuya Tsuchihara; Shelley L Berger; Richard P Hill; Russell G Jones; Ming Tsao; Murray O Robinson; Craig B Thompson; Guohua Pan; Tak W Mak
Journal:  Genes Dev       Date:  2011-05-15       Impact factor: 11.361

3.  11C-Acetate PET/CT in localized prostate cancer: a study with MRI and histopathologic correlation.

Authors:  Esther Mena; Baris Turkbey; Haresh Mani; Stephen Adler; Vladimir A Valera; Marcelino Bernardo; Vijay Shah; Thomas Pohida; Yolanda McKinney; Gideon Kwarteng; Dagane Daar; Maria L Lindenberg; Philip Eclarinal; Revia Wade; W Marston Linehan; Maria J Merino; Peter A Pinto; Peter L Choyke; Karen A Kurdziel
Journal:  J Nucl Med       Date:  2012-02-17       Impact factor: 10.057

4.  Elevated blood acetate as indicator of fast ethanol elimination in chronic alcoholics.

Authors:  H Nuutinen; K Lindros; P Hekali; M Salaspuro
Journal:  Alcohol       Date:  1985 Jul-Aug       Impact factor: 2.405

5.  Subcellular distribution of acetyl-CoA synthetase, ATP citrate lyase, citrate synthase, choline acetyltransferase, fumarate hydratase and lactate dehydrogenase in mammalian brain tissue.

Authors:  S Tucek
Journal:  J Neurochem       Date:  1967-05       Impact factor: 5.372

6.  Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis.

Authors:  Stuart F W Kendrick; Graeme O'Boyle; Jelena Mann; Mujdat Zeybel; Jeremy Palmer; David E J Jones; Chris P Day
Journal:  Hepatology       Date:  2010-06       Impact factor: 17.425

7.  The Nurture of Tumors Can Drive Their Metabolic Phenotype.

Authors:  Zachary T Schug; Johan Vande Voorde; Eyal Gottlieb
Journal:  Cell Metab       Date:  2016-03-08       Impact factor: 27.287

8.  Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine.

Authors:  V J Starai; I Celic; R N Cole; J D Boeke; J C Escalante-Semerena
Journal:  Science       Date:  2002-12-20       Impact factor: 47.728

Review 9.  18F-Choline, 11C-choline and 11C-acetate PET/CT: comparative analysis for imaging prostate cancer patients.

Authors:  Claudia Brogsitter; Klaus Zöphel; Jörg Kotzerke
Journal:  Eur J Nucl Med Mol Imaging       Date:  2013-04-12       Impact factor: 9.236

10.  Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport.

Authors:  Becky M Bola; Amy L Chadwick; Filippos Michopoulos; Kathryn G Blount; Brian A Telfer; Kaye J Williams; Paul D Smith; Susan E Critchlow; Ian J Stratford
Journal:  Mol Cancer Ther       Date:  2014-10-03       Impact factor: 6.261
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  91 in total

Review 1.  The plasticity of pancreatic cancer metabolism in tumor progression and therapeutic resistance.

Authors:  Douglas E Biancur; Alec C Kimmelman
Journal:  Biochim Biophys Acta Rev Cancer       Date:  2018-04-24       Impact factor: 10.680

2.  Failure to Maintain Acetate Homeostasis by Acetate-Activating Enzymes Impacts Plant Development.

Authors:  Xinyu Fu; Hannah Yang; Febriana Pangestu; Basil J Nikolau
Journal:  Plant Physiol       Date:  2019-12-24       Impact factor: 8.340

Review 3.  Recent advances in the metabolomic study of bladder cancer.

Authors:  Chandra Sekhar Amara; Venkatrao Vantaku; Yair Lotan; Nagireddy Putluri
Journal:  Expert Rev Proteomics       Date:  2019-02-26       Impact factor: 3.940

Review 4.  Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation.

Authors:  Sharanya Sivanand; Isabella Viney; Kathryn E Wellen
Journal:  Trends Biochem Sci       Date:  2017-11-23       Impact factor: 13.807

5.  PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism.

Authors:  Rachel R Stine; Alexander P Sakers; Tara TeSlaa; Megan Kissig; Zachary E Stine; Chan Wook Kwon; Lan Cheng; Hee-Woong Lim; Klaus H Kaestner; Joshua D Rabinowitz; Patrick Seale
Journal:  Cell Stem Cell       Date:  2019-09-26       Impact factor: 24.633

Review 6.  Single-Cell Techniques and Deep Learning in Predicting Drug Response.

Authors:  Zhenyu Wu; Patrick J Lawrence; Anjun Ma; Jian Zhu; Dong Xu; Qin Ma
Journal:  Trends Pharmacol Sci       Date:  2020-11-02       Impact factor: 14.819

7.  Extending the Scope of 1H NMR Spectroscopy for the Analysis of Cellular Coenzyme A and Acetyl Coenzyme A.

Authors:  G A Nagana Gowda; Lauren Abell; Rong Tian
Journal:  Anal Chem       Date:  2019-01-17       Impact factor: 6.986

Review 8.  Revisiting the hallmarks of cancer.

Authors:  Yousef Ahmed Fouad; Carmen Aanei
Journal:  Am J Cancer Res       Date:  2017-05-01       Impact factor: 6.166

Review 9.  Potential of electron transfer and its application in dictating routes of biochemical processes associated with metabolic reprogramming.

Authors:  Ronghui Yang; Guoguang Ying; Binghui Li
Journal:  Front Med       Date:  2021-07-24       Impact factor: 4.592

10.  Global and targeted circulating microRNA profiling of colorectal adenoma and colorectal cancer.

Authors:  Jinhua Zhang; Gottumakkala S Raju; David W Chang; Shu-Hong Lin; Zhinan Chen; Xifeng Wu
Journal:  Cancer       Date:  2017-11-07       Impact factor: 6.860
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