| Literature DB >> 27559109 |
Mariona Bustamante1,2,3,4, Marie Standl5, Quique Bassat6,7, Natalia Vilor-Tejedor8,3,4, Carolina Medina-Gomez9,10,11, Carolina Bonilla12,13, Tarunveer S Ahluwalia14, Jonas Bacelis15, Jonathan P Bradfield16, Carla M T Tiesler5,17, Fernando Rivadeneira9,10,11, Susan Ring12,13, Nadja H Vissing14, Nadia R Fink14, Astanand Jugessur18, Frank D Mentch16, Ferran Ballester4,19, Jennifer Kriebel20,21, Jessica C Kiefte-de Jong11,22,23, Helene M Wolsk14, Sabrina Llop4,19, Elisabeth Thiering5,17, Systke A Beth9,22, Nicholas J Timpson12,13, Josefine Andersen14, Holger Schulz5, Vincent W V Jaddoe9,22, David M Evans12,13,24, Johannes Waage14, Hakon Hakonarson16,25,26, Struan F A Grant16,25,26,27, Bo Jacobsson15,18, Klaus Bønnelykke14, Hans Bisgaard14, George Davey Smith12,13, Henriette A Moll22, Joachim Heinrich5,28, Xavier Estivill2,3,4,29,30, Jordi Sunyer8,3,4,29.
Abstract
More than a million childhood diarrhoeal episodes occur worldwide each year, and in developed countries a considerable part of them are caused by viral infections. In this study, we aimed to search for genetic variants associated with diarrhoeal disease in young children by meta-analyzing genome-wide association studies, and to elucidate plausible biological mechanisms. The study was conducted in the context of the Early Genetics and Lifecourse Epidemiology (EAGLE) consortium. Data about diarrhoeal disease in two time windows (around 1 year of age and around 2 years of age) was obtained via parental questionnaires, doctor interviews or medical records. Standard quality control and statistical tests were applied to the 1000 Genomes imputed genotypic data. The meta-analysis (N = 5758) followed by replication (N = 3784) identified a genome-wide significant association between rs8111874 and diarrhoea at age 1 year. Conditional analysis suggested that the causal variant could be rs601338 (W154X) in the FUT2 gene. Children with the A allele, which results in a truncated FUT2 protein, had lower risk of diarrhoea. FUT2 participates in the production of histo-blood group antigens and has previously been implicated in the susceptibility to infections, including Rotavirus and Norovirus Gene-set enrichment analysis suggested pathways related to the histo-blood group antigen production, and the regulation of ion transport and blood pressure. Among others, the gastrointestinal tract, and the immune and neuro-secretory systems were detected as relevant organs. In summary, this genome-wide association meta-analysis suggests the implication of the FUT2 gene in diarrhoeal disease in young children from the general population.Entities:
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Year: 2016 PMID： 27559109 PMCID： PMC5291237 DOI： 10.1093/hmg/ddw264
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150