Literature DB >> 27558608

Establishment of induced pluripotent stem cell (iPSC) line from a 75-year old patient with late onset Alzheimer's disease (LOAD).

Zsuzsanna Táncos1, Eszter Varga2, Eszter Kovács2, András Dinnyés1, Julianna Kobolák2.   

Abstract

Peripheral blood mononuclear cells (PBMCs) were collected from a clinically characterised 75-year old woman with late onset Alzheimer's disease (LOAD). The PMBCs were reprogrammed with the human OSKM transcription factors using the Sendai-virus delivery system. The transgene-free iPSC showed pluripotency verified by immunocytochemistry for pluripotency markers and differentiated spontaneously towards the 3 germ layers in vitro. Furthermore, the iPSC line showed normal karyotype. Our model might offer a good platform to further study the pathomechanism of sporadic AD, to identify early biomarkers and also for drug testing and gene therapy studies.
Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Entities:  

Year:  2016        PMID： 27558608     DOI： 10.1016/j.scr.2016.05.013

Source DB:  PubMed          Journal:  Stem Cell Res        ISSN： 1873-5061            Impact factor:   2.020


  6 in total

1.  Blood Derived Induced Pluripotent Stem Cells (iPSCs): Benefits, Challenges and the Road Ahead.

Authors:  Holly N Cukier; Jimmy El Hokayem; Derek M Dykxhoorn
Journal:  J Alzheimers Dis Parkinsonism       Date:  2016-10-25

Review 2.  3D culture models of Alzheimer's disease: a road map to a "cure-in-a-dish".

Authors:  Se Hoon Choi; Young Hye Kim; Luisa Quinti; Rudolph E Tanzi; Doo Yeon Kim
Journal:  Mol Neurodegener       Date:  2016-12-09       Impact factor: 14.195

3.  Robust and highly efficient hiPSC generation from patient non-mobilized peripheral blood-derived CD34+ cells using the auto-erasable Sendai virus vector.

Authors:  Takashi Okumura; Yumi Horie; Chen-Yi Lai; Huan-Ting Lin; Hirofumi Shoda; Bunki Natsumoto; Keishi Fujio; Eri Kumaki; Tsubasa Okano; Shintaro Ono; Kay Tanita; Tomohiro Morio; Hirokazu Kanegane; Hisanori Hasegawa; Fumitaka Mizoguchi; Kimito Kawahata; Hitoshi Kohsaka; Hiroshi Moritake; Hiroyuki Nunoi; Hironori Waki; Shin-Ichi Tamaru; Takayoshi Sasako; Toshimasa Yamauchi; Takashi Kadowaki; Hiroyuki Tanaka; Sachiko Kitanaka; Ken Nishimura; Manami Ohtaka; Mahito Nakanishi; Makoto Otsu
Journal:  Stem Cell Res Ther       Date:  2019-06-24       Impact factor: 6.832

Review 4.  An Overview on Promising Somatic Cell Sources Utilized for the Efficient Generation of Induced Pluripotent Stem Cells.

Authors:  Arnab Ray; Jahnavy Madhukar Joshi; Pradeep Kumar Sundaravadivelu; Khyati Raina; Nibedita Lenka; Vishwas Kaveeshwar; Rajkumar P Thummer
Journal:  Stem Cell Rev Rep       Date:  2021-06-07       Impact factor: 5.739

5.  Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation.

Authors:  Anna Ochalek; Balázs Mihalik; Hasan X Avci; Abinaya Chandrasekaran; Annamária Téglási; István Bock; Maria Lo Giudice; Zsuzsanna Táncos; Kinga Molnár; Lajos László; Jørgen E Nielsen; Bjørn Holst; Kristine Freude; Poul Hyttel; Julianna Kobolák; András Dinnyés
Journal:  Alzheimers Res Ther       Date:  2017-12-01       Impact factor: 6.982

6.  Optimizing the method for generation of integration-free induced pluripotent stem cells from human peripheral blood.

Authors:  Haihui Gu; Xia Huang; Jing Xu; Lili Song; Shuping Liu; Xiao-Bing Zhang; Weiping Yuan; Yanxin Li
Journal:  Stem Cell Res Ther       Date:  2018-06-15       Impact factor: 6.832
  6 in total

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