Fabienne Marquant1, Stéphanie Goujon1,2, Laure Faure1,2, Sandra Guissou3, Laurent Orsi1, Denis Hémon1, Brigitte Lacour3, Jacqueline Clavel1,2. 1. Epidemiology and Biostatistics Sorbonne Paris Cité Centre (CRESS), Epidemiology of childhood and adolescent cancers research group (EPICEA), INSERM, UMR 1153, Paris Descartes University, Villejuif, France. 2. French National Registry of Childhood Haematological Malignancies (NRCH), Villejuif, France. 3. French National Registry of Childhood Solid Tumours (NRCST), Vandoeuvre-les-Nancy, France.
Abstract
BACKGROUND: Socio-economic status is related to many life style and environmental factors, some of which have been suggested to influence the risk of childhood cancer. Studies requiring subject participation are usually hampered by selection of more educated parents. To prevent such bias, we used unselected nationwide Geographical Information System (GIS)-based registry data, to investigate the influence of socio-economic disparities on the risk of childhood cancer. METHODS: The Geocap study included all French residents diagnosed with cancer aged up to 15 years over the period 2002-2010 (15 111 cases) and 45 000 contemporaneous controls representative of the childhood population. Area socio-economic characteristics used to calculate the European Deprivation Index (EDI) were based on census data collected on the fine scale of the Merged Islet for Statistical Information (IRIS). RESULTS: Overall, the risk of acute lymphoblastic leukaemia (ALL) was lower in the most deprived quintile than in the other quintiles of EDI (ORQ5vs<Q5 0.80 (95% confidence interval (CI) 0.73, 0.88)). The odds ratio for all the other cancers taken together was close to the null (ORQ5vs<Q5 0.99 (95% CI 0.94, 1.04)). CONCLUSION: Living in the most deprived areas was inversely associated with the risk of ALL in childhood. There was no indication that the risk of childhood cancer of any site could be increased by deprivation. Life style or environmental factors potentially underlying the association need further investigation.
BACKGROUND: Socio-economic status is related to many life style and environmental factors, some of which have been suggested to influence the risk of childhood cancer. Studies requiring subject participation are usually hampered by selection of more educated parents. To prevent such bias, we used unselected nationwide Geographical Information System (GIS)-based registry data, to investigate the influence of socio-economic disparities on the risk of childhood cancer. METHODS: The Geocap study included all French residents diagnosed with cancer aged up to 15 years over the period 2002-2010 (15 111 cases) and 45 000 contemporaneous controls representative of the childhood population. Area socio-economic characteristics used to calculate the European Deprivation Index (EDI) were based on census data collected on the fine scale of the Merged Islet for Statistical Information (IRIS). RESULTS: Overall, the risk of acute lymphoblastic leukaemia (ALL) was lower in the most deprived quintile than in the other quintiles of EDI (ORQ5vs<Q5 0.80 (95% confidence interval (CI) 0.73, 0.88)). The odds ratio for all the other cancers taken together was close to the null (ORQ5vs<Q5 0.99 (95% CI 0.94, 1.04)). CONCLUSION: Living in the most deprived areas was inversely associated with the risk of ALL in childhood. There was no indication that the risk of childhood cancer of any site could be increased by deprivation. Life style or environmental factors potentially underlying the association need further investigation.
Authors: Aryana T Amoon; Catherine M Crespi; Anders Ahlbom; Megha Bhatnagar; Isabelle Bray; Kathryn J Bunch; Jacqueline Clavel; Maria Feychting; Denis Hémon; Christoffer Johansen; Christian Kreis; Carlotta Malagoli; Fabienne Marquant; Camilla Pedersen; Ole Raaschou-Nielsen; Martin Röösli; Ben D Spycher; Madhuri Sudan; John Swanson; Andrea Tittarelli; Deirdre M Tuck; Tore Tynes; Ximena Vergara; Marco Vinceti; Victor Wünsch-Filho; Leeka Kheifets Journal: Br J Cancer Date: 2018-05-29 Impact factor: 7.640
Authors: Eva Steliarova-Foucher; Miranda M Fidler; Murielle Colombet; Brigitte Lacour; Peter Kaatsch; Marion Piñeros; Isabelle Soerjomataram; Freddie Bray; Jan Willem Coebergh; Rafael Peris-Bonet; Charles A Stiller Journal: Lancet Oncol Date: 2018-08-08 Impact factor: 41.316