| Literature DB >> 27555082 |
Guowei Li1, Tolulope T Sajobi2, Bijoy K Menon2, Lawrence Korngut3, Mark Lowerison4, Matthew James5, Stephen B Wilton6, Tyler Williamson4, Stephanie Gill3, Lauren L Drogos6, Eric E Smith3, Sunita Vohra7, Michael D Hill2, Lehana Thabane8.
Abstract
Registry-based randomized controlled trials are defined as pragmatic trials that use registries as a platform for case records, data collection, randomization, and follow-up. Recently, the application of registry-based randomized controlled trials has attracted increasing attention in health research to address comparative effectiveness research questions in real-world settings, mainly due to their low cost, enhanced generalizability of findings, rapid consecutive enrollment, and the potential completeness of follow-up for the reference population, when compared with conventional randomized effectiveness trials. However several challenges of registry-based randomized controlled trials have to be taken into consideration, including registry data quality, ethical issues, and methodological challenges. In this article, we summarize the advantages, challenges, and areas for future research related to registry-based randomized controlled trials.Keywords: Clinical trial; Effectiveness; Pragmatic trial; Real-world setting; Registry; Registry-based randomized controlled trial
Mesh：
Year: 2016 PMID： 27555082 DOI： 10.1016/j.jclinepi.2016.08.003
Source DB: PubMed Journal: J Clin Epidemiol ISSN： 0895-4356 Impact factor: 6.437