Literature DB >> 27554127

Direct Cardiac Cellular Reprogramming for Cardiac Regeneration.

Vivekkumar Patel1, Megumi Mathison1, Vivek P Singh1, Jianchang Yang1, Todd K Rosengart2.   

Abstract

OPINION STATEMENT: Direct cardiac cellular reprogramming of endogenous cardiac fibroblasts directly into induced cardiomyocytes is a highly feasible, promising therapeutic option for patients with advanced heart failure. The most successful cardiac reprogramming strategy will likely be a multimodal approach involving an optimal combination of cardio-differentiating factors, suppression of fibroblast gene expression, and induction of angiogenic factors.

Entities:  

Keywords:  Cardiomyocyte; GMT; Gene therapy; Heart failure; Reprogramming; Transdifferentiation

Year:  2016        PMID： 27554127      PMCID： PMC5278776          DOI： 10.1007/s11936-016-0480-8

Source DB:  PubMed          Journal:  Curr Treat Options Cardiovasc Med        ISSN： 1092-8464


  46 in total

1.  In vivo cardiac reprogramming using an optimal single polycistronic construct.

Authors:  Hong Ma; Li Wang; Chaoying Yin; Jiandong Liu; Li Qian
Journal:  Cardiovasc Res       Date:  2015-09-23       Impact factor: 10.787

Review 2.  Pluripotent reprogramming and lineage reprogramming: promises and challenges in cardiovascular regeneration.

Authors:  Wen-Jun He; Qian Hou; Qing-Wang Han; Wei-Dong Han; Xiao-Bing Fu
Journal:  Tissue Eng Part B Rev       Date:  2013-11-13       Impact factor: 6.389

3.  Cardiac repair with thymosin β4 and cardiac reprogramming factors.

Authors:  Deepak Srivastava; Masaki Ieda; Jidong Fu; Li Qian
Journal:  Ann N Y Acad Sci       Date:  2012-10       Impact factor: 5.691

4.  Conversion of human fibroblasts into functional cardiomyocytes by small molecules.

Authors:  Nan Cao; Yu Huang; Jiashun Zheng; C Ian Spencer; Yu Zhang; Ji-Dong Fu; Baoming Nie; Min Xie; Mingliang Zhang; Haixia Wang; Tianhua Ma; Tao Xu; Guilai Shi; Deepak Srivastava; Sheng Ding
Journal:  Science       Date:  2016-04-28       Impact factor: 47.728

5.  MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures.

Authors:  Naoto Muraoka; Hiroyuki Yamakawa; Kazutaka Miyamoto; Taketaro Sadahiro; Tomohiko Umei; Mari Isomi; Hanae Nakashima; Mizuha Akiyama; Rie Wada; Kohei Inagawa; Takahiko Nishiyama; Ruri Kaneda; Toru Fukuda; Shu Takeda; Shugo Tohyama; Hisayuki Hashimoto; Yoshifumi Kawamura; Naoki Goshima; Ryo Aeba; Hiroyuki Yamagishi; Keiichi Fukuda; Masaki Ieda
Journal:  EMBO J       Date:  2014-06-11       Impact factor: 11.598

Review 6.  Management of the ACC/AHA Stage D patient: mechanical circulatory support.

Authors:  David A Baran; Abhishek Jaiswal
Journal:  Cardiol Clin       Date:  2014-02       Impact factor: 2.213

7.  Origins and fates of cardiovascular progenitor cells.

Authors:  Sean M Wu; Kenneth R Chien; Christine Mummery
Journal:  Cell       Date:  2008-02-22       Impact factor: 41.582

8.  Induction of human cardiomyocyte-like cells from fibroblasts by defined factors.

Authors:  Rie Wada; Naoto Muraoka; Kohei Inagawa; Hiroyuki Yamakawa; Kazutaka Miyamoto; Taketaro Sadahiro; Tomohiko Umei; Ruri Kaneda; Tomoyuki Suzuki; Kaichiro Kamiya; Shugo Tohyama; Shinsuke Yuasa; Kiyokazu Kokaji; Ryo Aeba; Ryohei Yozu; Hiroyuki Yamagishi; Toshio Kitamura; Keiichi Fukuda; Masaki Ieda
Journal:  Proc Natl Acad Sci U S A       Date:  2013-07-16       Impact factor: 11.205

9.  Cardiac gene activation analysis in mammalian non-myoblasic cells by Nkx2-5, Tbx5, Gata4 and Myocd.

Authors:  Lei Zhou; Yu Liu; Li Lu; Xinzheng Lu; Richard A F Dixon
Journal:  PLoS One       Date:  2012-10-29       Impact factor: 3.240

10.  Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming.

Authors:  Nicolas Christoforou; Malathi Chellappan; Andrew F Adler; Robert D Kirkton; Tianyi Wu; Russell C Addis; Nenad Bursac; Kam W Leong
Journal:  PLoS One       Date:  2013-05-21       Impact factor: 3.240
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  10 in total

Review 1.  Modulating Cell Fate as a Therapeutic Strategy.

Authors:  Brian Lin; Priya Srikanth; Alison C Castle; Sagar Nigwekar; Rajeev Malhotra; Jenna L Galloway; David B Sykes; Jayaraj Rajagopal
Journal:  Cell Stem Cell       Date:  2018-06-14       Impact factor: 24.633

2.  p63 silencing induces epigenetic modulation to enhance human cardiac fibroblast to cardiomyocyte-like differentiation.

Authors:  Jaya Pratap Pinnamaneni; Vivek P Singh; Mary B Kim; Christopher T Ryan; Aarthi Pugazenthi; Deepthi Sanagasetti; Megumi Mathison; Jianchang Yang; Todd K Rosengart
Journal:  Sci Rep       Date:  2022-07-06       Impact factor: 4.996

3.  Cardiac stem cell trials and the new world of cellular reprogramming: Time to move on.

Authors:  Todd K Rosengart; Vivek Patel; Frank W Sellke
Journal:  J Thorac Cardiovasc Surg       Date:  2017-12-26       Impact factor: 5.209

4.  Polycomb Repressive Complex 2 Proteins EZH1 and EZH2 Regulate Timing of Postnatal Hepatocyte Maturation and Fibrosis by Repressing Genes With Euchromatic Promoters in Mice.

Authors:  Jessica Mae Grindheim; Dario Nicetto; Greg Donahue; Kenneth S Zaret
Journal:  Gastroenterology       Date:  2019-01-25       Impact factor: 22.682

5.  Commentary: Doubling down on adeno-associated viruses for cardiac gene therapy.

Authors:  Christopher T Ryan; Ravi K Ghanta
Journal:  J Thorac Cardiovasc Surg       Date:  2019-11-05       Impact factor: 6.439

6.  Hippo Pathway Effector Tead1 Induces Cardiac Fibroblast to Cardiomyocyte Reprogramming.

Authors:  Vivek P Singh; Jaya P Pinnamaneni; Aarthi Pugazenthi; Deepthi Sanagasetti; Megumi Mathison; James F Martin; Jianchang Yang; Todd K Rosengart
Journal:  J Am Heart Assoc       Date:  2021-12-10       Impact factor: 6.106

7.  Enhanced Generation of Induced Cardiomyocytes Using a Small-Molecule Cocktail to Overcome Barriers to Cardiac Cellular Reprogramming.

Authors:  Vivek P Singh; Jaya Pratap Pinnamaneni; Aarthi Pugazenthi; Deepthi Sanagasetti; Megumi Mathison; Kai Wang; Jianchang Yang; Todd K Rosengart
Journal:  J Am Heart Assoc       Date:  2020-06-05       Impact factor: 5.501

8.  Commentary: Evidence-based human stem cell therapy for myocardial healing: Miles to go.

Authors:  Devendra K Agrawal; Finosh G Thankam
Journal:  JTCVS Open       Date:  2021-07-02

Review 9.  Bioengineering Technologies for Cardiac Regenerative Medicine.

Authors:  Mira Chingale; Dashuai Zhu; Ke Cheng; Ke Huang
Journal:  Front Bioeng Biotechnol       Date:  2021-06-03

10.  Cardiac-mimetic cell-culture system for direct cardiac reprogramming.

Authors:  Seuk Young Song; Jin Yoo; Seokhyeong Go; Jihye Hong; Hee Su Sohn; Ju-Ro Lee; Mikyung Kang; Gun-Jae Jeong; Seungmi Ryu; Seung Hyun L Kim; Nathaniel S Hwang; Kookheon Char; Byung-Soo Kim
Journal:  Theranostics       Date:  2019-09-19       Impact factor: 11.556
  10 in total

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