Literature DB >> 27553733

Peculiarities of data interpretation upon direct tissue analysis by Fourier transform ion cyclotron resonance mass spectrometry.

Vtaliy Chagovets1, Aleksey Kononikhin2, Nataliia Starodubtseva2, Yury Kostyukevich3, Igor Popov4, Vladimir Frankevich5, Eugene Nikolaev3.   

Abstract

The importance of high-resolution mass spectrometry for the correct data interpretation of a direct tissue analysis is demonstrated with an example of its clinical application for an endometriosis study. Multivariate analysis of the data discovers lipid species differentially expressed in different tissues under investigation. High-resolution mass spectrometry allows unambiguous separation of peaks with close masses that correspond to proton and sodium adducts of phosphatidylcholines and to phosphatidylcholines differing in double bond number.

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Year:  2016        PMID： 27553733     DOI： 10.1255/ejms.1425

Source DB:  PubMed          Journal:  Eur J Mass Spectrom (Chichester)        ISSN： 1469-0667            Impact factor:   1.067


  5 in total

1.  A Comparison of Tissue Spray and Lipid Extract Direct Injection Electrospray Ionization Mass Spectrometry for the Differentiation of Eutopic and Ectopic Endometrial Tissues.

Authors:  Vitaliy Chagovets; Zhihao Wang; Alexey Kononikhin; Natalia Starodubtseva; Anna Borisova; Dinara Salimova; Igor Popov; Andrey Kozachenko; Konstantin Chingin; Huanwen Chen; Vladimir Frankevich; Leila Adamyan; Gennady Sukhikh
Journal:  J Am Soc Mass Spectrom       Date:  2017-09-27       Impact factor: 3.109

2.  Shotgun Lipidomics for Differential Diagnosis of HPV-Associated Cervix Transformation.

Authors:  Natalia L Starodubtseva; Vitaliy V Chagovets; Maria E Nekrasova; Niso M Nazarova; Alisa O Tokareva; Olga V Bourmenskaya; Djamilja I Attoeva; Eugenii N Kukaev; Dmitriy Y Trofimov; Vladimir E Frankevich; Gennady T Sukhikh
Journal:  Metabolites       Date:  2022-05-31

3.  Validation of Breast Cancer Margins by Tissue Spray Mass Spectrometry.

Authors:  Vitaliy V Chagovets; Natalia L Starodubtseva; Alisa O Tokareva; Vladimir E Frankevich; Valerii V Rodionov; Vlada V Kometova; Konstantin Chingin; Eugene N Kukaev; Huanwen Chen; Gennady T Sukhikh
Journal:  Int J Mol Sci       Date:  2020-06-26       Impact factor: 5.923

4.  Alterations in lipid profile upon uterine fibroids and its recurrence.

Authors:  Narine M Tonoyan; Vitaliy V Chagovets; Natalia L Starodubtseva; Alisa O Tokareva; Konstantin Chingin; Irena F Kozachenko; Leyla V Adamyan; Vladimir E Frankevich
Journal:  Sci Rep       Date:  2021-06-01       Impact factor: 4.379

5.  Endometriosis foci differentiation by rapid lipid profiling using tissue spray ionization and high resolution mass spectrometry.

Authors:  Vitaliy V Chagovets; Zhihao Wang; Alexey S Kononikhin; Natalia L Starodubtseva; Anna Borisova; Dinara Salimova; Igor A Popov; Andrey V Kozachenko; Konstantin Chingin; Huanwen Chen; Vladimir E Frankevich; Leila V Adamyan; Gennady T Sukhikh
Journal:  Sci Rep       Date:  2017-05-31       Impact factor: 4.379
  5 in total

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