Literature DB >> 27553241

Serial Femtosecond Crystallography of Membrane Proteins.

Lan Zhu1,2, Uwe Weierstall2,3, Vadim Cherezov4,5, Wei Liu6,7.   

Abstract

Membrane proteins, including G protein-coupled receptors (GPCRs), constitute the most important drug targets. The increasing number of targets requires new structural information, which has proven tremendously challenging due to the difficulties in growing diffraction-quality crystals. Recent developments of serial femtosecond crystallography at X-ray free electron lasers combined with the use of membrane-mimetic gel-like matrix of lipidic cubic phase (LCP-SFX) for crystal growth and delivery hold significant promise to accelerate structural studies of membrane proteins. This chapter describes the development and current status of the LCP-SFX technology and elaborates its future role in structural biology of membrane proteins.

Entities:  

Keywords:  G protein-coupled receptors; LCP injector; LCP-SFX; Lipidic cubic phase; Membrane proteins; Serial femtosecond crystallography; X-ray free electron laser

Mesh：

Substances：

Year:  2016        PMID： 27553241      PMCID： PMC5110035          DOI： 10.1007/978-3-319-35072-1_11

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  40 in total

1.  Potential for biomolecular imaging with femtosecond X-ray pulses.

Authors:  R Neutze; R Wouts; D van der Spoel; E Weckert; J Hajdu
Journal:  Nature       Date:  2000-08-17       Impact factor: 49.962

2.  Rational design of lipid for membrane protein crystallization.

Authors:  Yohann Misquitta; Vadim Cherezov; Fabien Havas; Suzanne Patterson; Jakkam M Mohan; Angela J Wells; David J Hart; Martin Caffrey
Journal:  J Struct Biol       Date:  2004-11       Impact factor: 2.867

3.  Drug-target network.

Authors:  Muhammed A Yildirim; Kwang-Il Goh; Michael E Cusick; Albert-László Barabási; Marc Vidal
Journal:  Nat Biotechnol       Date:  2007-10       Impact factor: 54.908

4.  Accessing protein conformational ensembles using room-temperature X-ray crystallography.

Authors:  James S Fraser; Henry van den Bedem; Avi J Samelson; P Therese Lang; James M Holton; Nathaniel Echols; Tom Alber
Journal:  Proc Natl Acad Sci U S A       Date:  2011-09-14       Impact factor: 11.205

5.  Nanoflow electrospinning serial femtosecond crystallography.

Authors:  Raymond G Sierra; Hartawan Laksmono; Jan Kern; Rosalie Tran; Johan Hattne; Roberto Alonso-Mori; Benedikt Lassalle-Kaiser; Carina Glöckner; Julia Hellmich; Donald W Schafer; Nathaniel Echols; Richard J Gildea; Ralf W Grosse-Kunstleve; Jonas Sellberg; Trevor A McQueen; Alan R Fry; Marc M Messerschmidt; Alan Miahnahri; M Marvin Seibert; Christina Y Hampton; Dmitri Starodub; N Duane Loh; Dimosthenis Sokaras; Tsu-Chien Weng; Petrus H Zwart; Pieter Glatzel; Despina Milathianaki; William E White; Paul D Adams; Garth J Williams; Sébastien Boutet; Athina Zouni; Johannes Messinger; Nicholas K Sauter; Uwe Bergmann; Junko Yano; Vittal K Yachandra; Michael J Bogan
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2012-10-18

6.  Femtosecond protein nanocrystallography-data analysis methods.

Authors:  Richard A Kirian; Xiaoyu Wang; Uwe Weierstall; Kevin E Schmidt; John C H Spence; Mark Hunter; Petra Fromme; Thomas White; Henry N Chapman; James Holton
Journal:  Opt Express       Date:  2010-03-15       Impact factor: 3.894

7.  Microfluidic Generation of Lipidic Mesophases for Membrane Protein Crystallization.

Authors:  Sarah L Perry; Griffin W Roberts; Joshua D Tice; Robert B Gennis; Paul J A Kenis
Journal:  Cryst Growth Des       Date:  2009-06-03       Impact factor: 4.076

8.  Structure of the Angiotensin receptor revealed by serial femtosecond crystallography.

Authors:  Haitao Zhang; Hamiyet Unal; Cornelius Gati; Gye Won Han; Wei Liu; Nadia A Zatsepin; Daniel James; Dingjie Wang; Garrett Nelson; Uwe Weierstall; Michael R Sawaya; Qingping Xu; Marc Messerschmidt; Garth J Williams; Sébastien Boutet; Oleksandr M Yefanov; Thomas A White; Chong Wang; Andrii Ishchenko; Kalyan C Tirupula; Russell Desnoyer; Jesse Coe; Chelsie E Conrad; Petra Fromme; Raymond C Stevens; Vsevolod Katritch; Sadashiva S Karnik; Vadim Cherezov
Journal:  Cell       Date:  2015-04-23       Impact factor: 41.582

9.  Structural basis for bifunctional peptide recognition at human δ-opioid receptor.

Authors:  Gustavo Fenalti; Nadia A Zatsepin; Cecilia Betti; Patrick Giguere; Gye Won Han; Andrii Ishchenko; Wei Liu; Karel Guillemyn; Haitao Zhang; Daniel James; Dingjie Wang; Uwe Weierstall; John C H Spence; Sébastien Boutet; Marc Messerschmidt; Garth J Williams; Cornelius Gati; Oleksandr M Yefanov; Thomas A White; Dominik Oberthuer; Markus Metz; Chun Hong Yoon; Anton Barty; Henry N Chapman; Shibom Basu; Jesse Coe; Chelsie E Conrad; Raimund Fromme; Petra Fromme; Dirk Tourwé; Peter W Schiller; Bryan L Roth; Steven Ballet; Vsevolod Katritch; Raymond C Stevens; Vadim Cherezov
Journal:  Nat Struct Mol Biol       Date:  2015-02-16       Impact factor: 15.369

10.  Structure of a photosynthetic reaction centre determined by serial femtosecond crystallography.

Authors:  Linda C Johansson; David Arnlund; Gergely Katona; Thomas A White; Anton Barty; Daniel P DePonte; Robert L Shoeman; Cecilia Wickstrand; Amit Sharma; Garth J Williams; Andrew Aquila; Michael J Bogan; Carl Caleman; Jan Davidsson; R Bruce Doak; Matthias Frank; Raimund Fromme; Lorenzo Galli; Ingo Grotjohann; Mark S Hunter; Stephan Kassemeyer; Richard A Kirian; Christopher Kupitz; Mengning Liang; Lukas Lomb; Erik Malmerberg; Andrew V Martin; Marc Messerschmidt; Karol Nass; Lars Redecke; M Marvin Seibert; Jennie Sjöhamn; Jan Steinbrener; Francesco Stellato; Dingjie Wang; Weixaio Y Wahlgren; Uwe Weierstall; Sebastian Westenhoff; Nadia A Zatsepin; Sébastien Boutet; John C H Spence; Ilme Schlichting; Henry N Chapman; Petra Fromme; Richard Neutze
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919
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  1 in total

1.  Challenges in solving structures from radiation-damaged tomograms of protein nanocrystals assessed by simulation.

Authors:  Ariana Peck; Qing Yao; Aaron S Brewster; Petrus H Zwart; John M Heumann; Nicholas K Sauter; Grant J Jensen
Journal:  Acta Crystallogr D Struct Biol       Date:  2021-04-14       Impact factor: 7.652
  1 in total

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