David J Roach1,2, Yannick Crémillieux3, Robert J Fleck4, Alan S Brody4, Suraj D Serai4, Rhonda D Szczesniak5, Stephanie Kerlakian2, John P Clancy2, Jason C Woods1,2,4. 1. 1 Center for Pulmonary Imaging Research. 2. 2 Division of Pulmonary Medicine. 3. 3 Centre de Résonance Magnétique des Systèmes Biologiques, Centre National de la Recherche Scientifique, Université de Bordeaux, Bordeaux, France. 4. 4 Radiology Department, and. 5. 5 Biostatistics and Epidemiology Department, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; and.
Abstract
RATIONALE: Recent advancements that have been made in magnetic resonance imaging (MRI) improve our ability to assess pulmonary structure and function in patients with cystic fibrosis (CF). A nonionizing imaging modality that can be used as a serial monitoring tool throughout life can positively affect patient care and outcomes. OBJECTIVES: To compare an ultrashort echo-time MRI method with computed tomography (CT) as a biomarker of lung structure abnormalities in young children with early CF lung disease. METHODS: Eleven patients with CF (mean age, 31.8 ± 5.7 mo; median age, 33 mo; 7 male and 4 female) were imaged via CT and ultrashort echo-time MRI. Eleven healthy age-matched patients (mean age, 22.5 ± 10.2 mo; median age, 23 mo; 5 male and 6 female) were imaged via ultrashort echo-time MRI. CT scans of 13 additional patients obtained for clinical indications not affecting the heart or lungs and interpreted as normal provided a CT control group (mean age, 24.1 ± 11.7 mo; median age, 24 mo; 6 male and 7 female). Studies were scored by two experienced radiologists using a well-validated CF-specific scoring system for CF lung disease. MEASUREMENTS AND MAIN RESULTS: Correlations between CT and ultrashort echo-time MRI scores of patients with CF were very strong, with P values ≤0.001 for bronchiectasis (r = 0.96) and overall score (r = 0.90), and moderately strong for bronchial wall thickening (r = 0.62, P = 0.043). MRI easily differentiated CF and control groups via a reader CF-specific scoring system. CONCLUSIONS: Ultrashort echo-time MRI detected structural lung disease in very young patients with CF and provided imaging data that correlated well with CT. By quantifying early CF lung disease without using ionizing radiation, ultrashort echo-time MRI appears well suited for pediatric patients requiring longitudinal imaging for clinical care or research studies. Clinical Trial registered with www.clinicaltrials.gov (NCT01832519).
RATIONALE: Recent advancements that have been made in magnetic resonance imaging (MRI) improve our ability to assess pulmonary structure and function in patients with cystic fibrosis (CF). A nonionizing imaging modality that can be used as a serial monitoring tool throughout life can positively affect patient care and outcomes. OBJECTIVES: To compare an ultrashort echo-time MRI method with computed tomography (CT) as a biomarker of lung structure abnormalities in young children with early CF lung disease. METHODS: Eleven patients with CF (mean age, 31.8 ± 5.7 mo; median age, 33 mo; 7 male and 4 female) were imaged via CT and ultrashort echo-time MRI. Eleven healthy age-matched patients (mean age, 22.5 ± 10.2 mo; median age, 23 mo; 5 male and 6 female) were imaged via ultrashort echo-time MRI. CT scans of 13 additional patients obtained for clinical indications not affecting the heart or lungs and interpreted as normal provided a CT control group (mean age, 24.1 ± 11.7 mo; median age, 24 mo; 6 male and 7 female). Studies were scored by two experienced radiologists using a well-validated CF-specific scoring system for CF lung disease. MEASUREMENTS AND MAIN RESULTS: Correlations between CT and ultrashort echo-time MRI scores of patients with CF were very strong, with P values ≤0.001 for bronchiectasis (r = 0.96) and overall score (r = 0.90), and moderately strong for bronchial wall thickening (r = 0.62, P = 0.043). MRI easily differentiated CF and control groups via a reader CF-specific scoring system. CONCLUSIONS: Ultrashort echo-time MRI detected structural lung disease in very young patients with CF and provided imaging data that correlated well with CT. By quantifying early CF lung disease without using ionizing radiation, ultrashort echo-time MRI appears well suited for pediatric patients requiring longitudinal imaging for clinical care or research studies. Clinical Trial registered with www.clinicaltrials.gov (NCT01832519).
Entities:
Keywords:
cystic fibrosis; lung; magnetic resonance imaging; ultrashort echo-time
Authors: Monika Eichinger; Daiva-Elzbieta Optazaite; Annette Kopp-Schneider; Christian Hintze; Jürgen Biederer; Anne Niemann; Marcus A Mall; Mark O Wielpütz; Hans-Ulrich Kauczor; Michael Puderbach Journal: Eur J Radiol Date: 2011-03-23 Impact factor: 3.528
Authors: Robert P Thomen; Ajay Sheshadri; James D Quirk; Jim Kozlowski; Henry D Ellison; Rhonda D Szczesniak; Mario Castro; Jason C Woods Journal: Radiology Date: 2014-08-19 Impact factor: 11.105
Authors: Leonie A Tepper; Pierluigi Ciet; Daan Caudri; Alexandra L Quittner; Elisabeth M W J Utens; Harm A W M Tiddens Journal: Pediatr Pulmonol Date: 2015-10-05
Authors: Francesca Pennati; James D Quirk; Dmitriy A Yablonskiy; Mario Castro; Andrea Aliverti; Jason C Woods Journal: Radiology Date: 2014-06-15 Impact factor: 11.105
Authors: Kun Qing; Kai Ruppert; Yun Jiang; Jaime F Mata; G Wilson Miller; Y Michael Shim; Chengbo Wang; Iulian C Ruset; F William Hersman; Talissa A Altes; John P Mugler Journal: J Magn Reson Imaging Date: 2013-05-16 Impact factor: 4.813
Authors: Peter D Sly; Siobhain Brennan; Catherine Gangell; Nicholas de Klerk; Conor Murray; Lauren Mott; Stephen M Stick; Philip J Robinson; Colin F Robertson; Sarath C Ranganathan Journal: Am J Respir Crit Care Med Date: 2009-04-16 Impact factor: 21.405
Authors: Marcus J Couch; Robert Thomen; Nikhil Kanhere; Raymond Hu; Felix Ratjen; Jason Woods; Giles Santyr Journal: J Cyst Fibros Date: 2019-03-25 Impact factor: 5.482
Authors: Wei Zha; Sean B Fain; Mark L Schiebler; Michael D Evans; Scott K Nagle; Fang Liu Journal: J Magn Reson Imaging Date: 2019-04-04 Impact factor: 4.813
Authors: Robert P Thomen; Laura L Walkup; David J Roach; Nara Higano; Andrew Schapiro; Alan Brody; John P Clancy; Zackary I Cleveland; Jason C Woods Journal: Am J Respir Crit Care Med Date: 2020-07-15 Impact factor: 21.405
Authors: Jason C Woods; Jim M Wild; Mark O Wielpütz; John P Clancy; Hiroto Hatabu; Hans-Ulrich Kauczor; Edwin J R van Beek; Talissa A Altes Journal: J Magn Reson Imaging Date: 2019-12-17 Impact factor: 4.813