Literature DB >> 27545067

Contraception: Search for an Ideal Unisex Mechanism by Targeting Ion Channels.

Polina V Lishko1.   

Abstract

Targeting sperm ion channels and other sperm-specific proteins is an effective way to develop unisex contraceptives, as they should have decreased side effects. This Science & Society summarizes the current advances in human sperm physiology in attempts to evaluate what would be appropriate targets for unisex contraceptives.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27545067      PMCID： PMC5364274          DOI： 10.1016/j.tibs.2016.08.002

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  15 in total

1.  Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the alpha/beta hydrolase domain containing 2 gene.

Authors:  Keishi Miyata; Yuichi Oike; Takayuki Hoshii; Hiromitsu Maekawa; Hisao Ogawa; Toshio Suda; Kimi Araki; Ken-ichi Yamamura
Journal:  Biochem Biophys Res Commun       Date:  2005-04-01       Impact factor: 3.575

2.  The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm.

Authors:  Timo Strünker; Normann Goodwin; Christoph Brenker; Nachiket D Kashikar; Ingo Weyand; Reinhard Seifert; U Benjamin Kaupp
Journal:  Nature       Date:  2011-03-17       Impact factor: 49.962

3.  Progesterone activates the principal Ca2+ channel of human sperm.

Authors:  Polina V Lishko; Inna L Botchkina; Yuriy Kirichok
Journal:  Nature       Date:  2011-03-17       Impact factor: 49.962

4.  The SLO3 sperm-specific potassium channel plays a vital role in male fertility.

Authors:  Celia M Santi; Pablo Martínez-López; José Luis de la Vega-Beltrán; Alice Butler; Arturo Alisio; Alberto Darszon; Lawrence Salkoff
Journal:  FEBS Lett       Date:  2010-02-09       Impact factor: 4.124

5.  Disruption of the principal, progesterone-activated sperm Ca2+ channel in a CatSper2-deficient infertile patient.

Authors:  James F Smith; Olga Syritsyna; Marc Fellous; Catherine Serres; Nadja Mannowetz; Yuriy Kirichok; Polina V Lishko
Journal:  Proc Natl Acad Sci U S A       Date:  2013-03-25       Impact factor: 11.205

6.  A sperm ion channel required for sperm motility and male fertility.

Authors:  D Ren; B Navarro; G Perez; A C Jackson; S Hsu; Q Shi; J L Tilly; D E Clapham
Journal:  Nature       Date:  2001-10-11       Impact factor: 49.962

7.  The Ca2+-activated K+ current of human sperm is mediated by Slo3.

Authors:  Christoph Brenker; Yu Zhou; Astrid Müller; Fabio Andres Echeverry; Christian Trötschel; Ansgar Poetsch; Xiao-Ming Xia; Wolfgang Bönigk; Christopher J Lingle; U Benjamin Kaupp; Timo Strünker
Journal:  Elife       Date:  2014-03-26       Impact factor: 8.140

8.  A common mutation in the defensin DEFB126 causes impaired sperm function and subfertility.

Authors:  Theodore L Tollner; Scott A Venners; Edward J Hollox; Ashley I Yudin; Xue Liu; Genfu Tang; Houxun Xing; Robert J Kays; Tsang Lau; James W Overstreet; Xiping Xu; Charles L Bevins; Gary N Cherr
Journal:  Sci Transl Med       Date:  2011-07-20       Impact factor: 17.956

9.  Slo1 is the principal potassium channel of human spermatozoa.

Authors:  Nadja Mannowetz; Natasha M Naidoo; Seung-A Sara Choo; James F Smith; Polina V Lishko
Journal:  Elife       Date:  2013-10-08       Impact factor: 8.140

10.  Patch clamp studies of human sperm under physiological ionic conditions reveal three functionally and pharmacologically distinct cation channels.

Authors:  S A Mansell; S J Publicover; C L R Barratt; S M Wilson
Journal:  Mol Hum Reprod       Date:  2014-01-16       Impact factor: 4.025
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  6 in total

Review 1.  Emerging approaches to male contraception.

Authors:  Arthi Thirumalai; John K Amory
Journal:  Fertil Steril       Date:  2021-04-27       Impact factor: 7.490

Review 2.  Development of Novel Male Contraceptives.

Authors:  John K Amory
Journal:  Clin Transl Sci       Date:  2019-11-14       Impact factor: 4.689

3.  A novel Hv1 inhibitor reveals a new mechanism of inhibition of a voltage-sensing domain.

Authors:  Chang Zhao; Liang Hong; Saleh Riahi; Victoria T Lim; Douglas J Tobias; Francesco Tombola
Journal:  J Gen Physiol       Date:  2021-07-06       Impact factor: 4.086

4.  Pharmacological Inactivation of CatSper Blocks Sperm Fertilizing Ability Independently of the Capacitation Status of the Cells: Implications for Non-hormonal Contraception.

Authors:  Ludmila Curci; Guillermo Carvajal; Valeria Sulzyk; Soledad Natalia Gonzalez; Patricia S Cuasnicú
Journal:  Front Cell Dev Biol       Date:  2021-07-06

5.  Human sperm ion channel (dys)function: implications for fertilization.

Authors:  Sean G Brown; Stephen J Publicover; Christopher L R Barratt; Sarah J Martins da Silva
Journal:  Hum Reprod Update       Date:  2019-11-05       Impact factor: 15.610

6.  HIFs: New arginine mimic inhibitors of the Hv1 channel with improved VSD-ligand interactions.

Authors:  Chang Zhao; Liang Hong; Jason D Galpin; Saleh Riahi; Victoria T Lim; Parker D Webster; Douglas J Tobias; Christopher A Ahern; Francesco Tombola
Journal:  J Gen Physiol       Date:  2021-07-06       Impact factor: 4.086
  6 in total

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