Literature DB >> 11595941

A sperm ion channel required for sperm motility and male fertility.

D Ren1, B Navarro, G Perez, A C Jackson, S Hsu, Q Shi, J L Tilly, D E Clapham.   

Abstract

Calcium and cyclic nucleotides have crucial roles in mammalian fertilization, but the molecules comprising the Ca2+-permeation pathway in sperm motility are poorly understood. Here we describe a putative sperm cation channel, CatSper, whose amino-acid sequence most closely resembles a single, six-transmembrane-spanning repeat of the voltage-dependent Ca2+-channel four-repeat structure. CatSper is located specifically in the principal piece of the sperm tail. Targeted disruption of the gene results in male sterility in otherwise normal mice. Sperm motility is decreased markedly in CatSper-/- mice, and CatSper-/- sperm are unable to fertilize intact eggs. In addition, the cyclic-AMP-induced Ca2+ influx is abolished in the sperm of mutant mice. CatSper is thus vital to cAMP-mediated Ca2+ influx in sperm, sperm motility and fertilization. CatSper represents an excellent target for non-hormonal contraceptives for both men and women.

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Year:  2001        PMID： 11595941      PMCID： PMC8462998          DOI： 10.1038/35098027

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  19 in total

1.  Nomenclature of voltage-gated calcium channels.

Authors:  E A Ertel; K P Campbell; M M Harpold; F Hofmann; Y Mori; E Perez-Reyes; A Schwartz; T P Snutch; T Tanabe; L Birnbaumer; R W Tsien; W A Catterall
Journal:  Neuron       Date:  2000-03       Impact factor: 17.173

Review 2.  A profile of fertilization in mammals.

Authors:  P M Wassarman; L Jovine; E S Litscher
Journal:  Nat Cell Biol       Date:  2001-02       Impact factor: 28.824

Review 3.  Ion channels in sperm physiology.

Authors:  A Darszon; P Labarca; T Nishigaki; F Espinosa
Journal:  Physiol Rev       Date:  1999-04       Impact factor: 37.312

4.  Trp2 regulates entry of Ca2+ into mouse sperm triggered by egg ZP3.

Authors:  M K Jungnickel; H Marrero; L Birnbaumer; J R Lémos; H M Florman
Journal:  Nat Cell Biol       Date:  2001-05       Impact factor: 28.824

5.  A dihydropyridine-sensitive T-type Ca2+ current is the main Ca2+ current carrier in mouse primary spermatocytes.

Authors:  C M Santi; A Darszon; A Hernández-Cruz
Journal:  Am J Physiol       Date:  1996-11

6.  Calcium-dependent increase in adenosine 3',5'-monophosphate and induction of the acrosome reaction in guinea pig spermatozoa.

Authors:  R V Hyne; D L Garbers
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

7.  Ca(2+) entry through store-operated channels in mouse sperm is initiated by egg ZP3 and drives the acrosome reaction.

Authors:  C M O'Toole; C Arnoult; A Darszon; R A Steinhardt; H M Florman
Journal:  Mol Biol Cell       Date:  2000-05       Impact factor: 4.138

8.  CaV2.2 and CaV2.3 (N- and R-type) Ca2+ channels in depolarization-evoked entry of Ca2+ into mouse sperm.

Authors:  G Wennemuth; R E Westenbroek; T Xu; B Hille; D F Babcock
Journal:  J Biol Chem       Date:  2000-07-14       Impact factor: 5.157

9.  Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency.

Authors:  G I Perez; R Robles; C M Knudson; J A Flaws; S J Korsmeyer; J L Tilly
Journal:  Nat Genet       Date:  1999-02       Impact factor: 38.330

10.  Cyclic nucleotide-gated channels on the flagellum control Ca2+ entry into sperm.

Authors:  B Wiesner; J Weiner; R Middendorff; V Hagen; U B Kaupp; I Weyand
Journal:  J Cell Biol       Date:  1998-07-27       Impact factor: 10.539
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  284 in total

1.  A flagellar K(+)-dependent Na(+)/Ca(2+) exchanger keeps Ca(2+) low in sea urchin spermatozoa.

Authors:  Yi-Hsien Su; Victor D Vacquier
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-14       Impact factor: 11.205

2.  CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm.

Authors:  Anne E Carlson; Ruth E Westenbroek; Timothy Quill; Dejian Ren; David E Clapham; Bertil Hille; David L Garbers; Donner F Babcock
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-01       Impact factor: 11.205

3.  Hyperactivated sperm motility driven by CatSper2 is required for fertilization.

Authors:  Timothy A Quill; Sarah A Sugden; Kristen L Rossi; Lynda K Doolittle; Robert E Hammer; David L Garbers
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-01       Impact factor: 11.205

4.  Positive selection on protein-length in the evolution of a primate sperm ion channel.

Authors:  Ondrej Podlaha; Jianzhi Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-01       Impact factor: 11.205

5.  A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets.

Authors:  Nikolaus Schultz; F Kent Hamra; David L Garbers
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-02       Impact factor: 11.205

6.  Sperm-specific protein kinase A catalytic subunit Calpha2 orchestrates cAMP signaling for male fertility.

Authors:  Michael A Nolan; Donner F Babcock; Gunther Wennemuth; William Brown; Kimberly A Burton; G Stanley McKnight
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-31       Impact factor: 11.205

7.  Regulation of fertilization in male rats by CatSper2 knockdown.

Authors:  Zhen Zhang; Gen-Lin Wang; Hui-Xia Li; Lian Li; Qun-Wei Cui; Cheng-Bin Wei; Fei Zhou
Journal:  Asian J Androl       Date:  2011-10-17       Impact factor: 3.285

8.  Evolution and spermatogenesis.

Authors:  Helen White-Cooper; Nina Bausek
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2010-05-27       Impact factor: 6.237

Review 9.  Rethinking the relationship between hyperactivation and chemotaxis in mammalian sperm.

Authors:  Haixin Chang; Susan S Suarez
Journal:  Biol Reprod       Date:  2010-05-12       Impact factor: 4.285

10.  A novel cross-species inhibitor to study the function of CatSper Ca2+ channels in sperm.

Authors:  Andreas Rennhack; Christian Schiffer; Christoph Brenker; Dmitry Fridman; Elis T Nitao; Yi-Min Cheng; Lara Tamburrino; Melanie Balbach; Gabriel Stölting; Thomas K Berger; Michelina Kierzek; Luis Alvarez; Dagmar Wachten; Xu-Hui Zeng; Elisabetta Baldi; Stephen J Publicover; U Benjamin Kaupp; Timo Strünker
Journal:  Br J Pharmacol       Date:  2018-06-29       Impact factor: 8.739
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