J Lysgaard Poulsen1, J Stubbe2, J S Lindholt3. 1. Elitary Research Centre of Individualized Medicine in Arterial Disease (CIMA), Denmark; Department of Cardiothoracic and Vascular Surgery T, Odense University Hospital, Denmark. Electronic address: jannie@demiry.dk. 2. Elitary Research Centre of Individualized Medicine in Arterial Disease (CIMA), Denmark; Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Denmark. 3. Elitary Research Centre of Individualized Medicine in Arterial Disease (CIMA), Denmark; Department of Cardiothoracic and Vascular Surgery T, Odense University Hospital, Denmark.
Abstract
OBJECTIVE: Experimental animal models have been used to investigate the formation, development, and progression of abdominal aortic aneurysms (AAAs) for decades. New models are constantly being developed to imitate the mechanisms of human AAAs and to identify treatments that are less risky than those used today. However, to the authors' knowledge, there is no model identical to the human AAA. The objective of this systematic review was to assess the different types of animal models used to investigate the development, progression, and treatment of AAA and to highlight their advantages and limitations. METHODS: A search protocol was used to perform a systematic literature search of PubMed and Embase. A total of 2,830 records were identified. After selection of the relevant articles, 564 papers on animal AAA models were included. RESULTS: The most common models in rodents, including elastase, calcium chloride, angiotensin II, xenograft, and transgenic models, and the most common models in non-rodents, including chemically induced, graft models, and patch models, all have limitations with regard to the pathological interpretation of human AAA. CONCLUSION: Although findings from animal models of AAAs cannot be directly translated to human AAAs, the identification and awareness of animal models of AAA will provide knowledge for further investigation and insight into human AAA disease.
OBJECTIVE: Experimental animal models have been used to investigate the formation, development, and progression of abdominal aortic aneurysms (AAAs) for decades. New models are constantly being developed to imitate the mechanisms of human AAAs and to identify treatments that are less risky than those used today. However, to the authors' knowledge, there is no model identical to the human AAA. The objective of this systematic review was to assess the different types of animal models used to investigate the development, progression, and treatment of AAA and to highlight their advantages and limitations. METHODS: A search protocol was used to perform a systematic literature search of PubMed and Embase. A total of 2,830 records were identified. After selection of the relevant articles, 564 papers on animal AAA models were included. RESULTS: The most common models in rodents, including elastase, calcium chloride, angiotensin II, xenograft, and transgenic models, and the most common models in non-rodents, including chemically induced, graft models, and patch models, all have limitations with regard to the pathological interpretation of human AAA. CONCLUSION: Although findings from animal models of AAAs cannot be directly translated to human AAAs, the identification and awareness of animal models of AAA will provide knowledge for further investigation and insight into human AAA disease.
Authors: Andrea Acuna; Alycia G Berman; Frederick W Damen; Brett A Meyers; Amelia R Adelsperger; Kelsey C Bayer; Melissa C Brindise; Brittani Bungart; Alexander M Kiel; Rachel A Morrison; Joseph C Muskat; Kelsey M Wasilczuk; Yi Wen; Jiacheng Zhang; Patrick Zito; Craig J Goergen Journal: J Biomech Eng Date: 2018-08-01 Impact factor: 2.097
Authors: Austin J Cocciolone; Jie Z Hawes; Marius C Staiculescu; Elizabeth O Johnson; Monzur Murshed; Jessica E Wagenseil Journal: Am J Physiol Heart Circ Physiol Date: 2018-04-06 Impact factor: 4.733