OBJECTIVE: We introduce a method for analyzing dynamically changing functional magnetic resonance imaging (fMRI) network connectivity estimates as they vary within and between broad functional domains. The method captures evidence of intertemporal directionality in cross joint functional-domain influence and extends standard whole-brain dynamic network connectivity approaches into additional functionally meaningful dimensions by evaluating transition probabilities between clustered intradomain and interdomain connectivity patterns. Results: In applying this method to a large (N = 314) multisite resting-state fMRI dataset balanced between schizophrenia patients and healthy controls, we find evidence of joint functional domains that are global catalyzers, broadly shaping downstream functional relationships throughout the brain. Multiple interesting differences between patients and controls in both time-varying joint functional-domain connectivity patterns and in cross joint functional-domain intertemporal information flow were identified. Conclusion and Significance: Our proposed approach, thus, unifies the concepts of brain connectivity and interdomain connectivity and provides a powerful new way to evaluate functional connectivity data in the context of both the healthy and diseased brain.
OBJECTIVE: We introduce a method for analyzing dynamically changing functional magnetic resonance imaging (fMRI) network connectivity estimates as they vary within and between broad functional domains. The method captures evidence of intertemporal directionality in cross joint functional-domain influence and extends standard whole-brain dynamic network connectivity approaches into additional functionally meaningful dimensions by evaluating transition probabilities between clustered intradomain and interdomain connectivity patterns. Results: In applying this method to a large (N = 314) multisite resting-state fMRI dataset balanced between schizophrenia patients and healthy controls, we find evidence of joint functional domains that are global catalyzers, broadly shaping downstream functional relationships throughout the brain. Multiple interesting differences between patients and controls in both time-varying joint functional-domain connectivity patterns and in cross joint functional-domain intertemporal information flow were identified. Conclusion and Significance: Our proposed approach, thus, unifies the concepts of brain connectivity and interdomain connectivity and provides a powerful new way to evaluate functional connectivity data in the context of both the healthy and diseased brain.
Authors: R Matthew Hutchison; Thilo Womelsdorf; Elena A Allen; Peter A Bandettini; Vince D Calhoun; Maurizio Corbetta; Stefania Della Penna; Jeff H Duyn; Gary H Glover; Javier Gonzalez-Castillo; Daniel A Handwerker; Shella Keilholz; Vesa Kiviniemi; David A Leopold; Francesco de Pasquale; Olaf Sporns; Martin Walter; Catie Chang Journal: Neuroimage Date: 2013-05-24 Impact factor: 6.556
Authors: Shruti Gopal; Robyn L Miller; Andrew Michael; Tulay Adali; Mustafa Cetin; Srinivas Rachakonda; Juan R Bustillo; Nathan Cahill; Stefi A Baum; Vince D Calhoun Journal: Schizophr Bull Date: 2015-06-23 Impact factor: 9.306
Authors: E Damaraju; E A Allen; A Belger; J M Ford; S McEwen; D H Mathalon; B A Mueller; G D Pearlson; S G Potkin; A Preda; J A Turner; J G Vaidya; T G van Erp; V D Calhoun Journal: Neuroimage Clin Date: 2014-07-24 Impact factor: 4.881
Authors: Victor M Vergara; Eswar Damaraju; Jessica A Turner; Godfrey Pearlson; Aysenil Belger; Daniel H Mathalon; Steven G Potkin; Adrian Preda; Jatin G Vaidya; Theo G M van Erp; Sarah McEwen; Vince D Calhoun Journal: Front Psychiatry Date: 2019-07-23 Impact factor: 4.157