| Literature DB >> 27540855 |
Arnob Dutta1, Susan M Abmayr2, Jerry L Workman3.
Abstract
Modifications of histones play important roles in balancing transcriptional output. The discovery of acyl marks, besides histone acetylation, has added to the functional diversity of histone modifications. Since all modifications use metabolic intermediates as substrates for chromatin-modifying enzymes, the prevalent landscape of histone modifications in any cell type is a snapshot of its metabolic status. Here, we review some of the current findings of how differential use of histone acylations regulates gene expression as response to metabolic changes and differentiation programs.Entities:
Keywords: YEATS domain; bromodomain; histone acylation; metabolism
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Year: 2016 PMID: 27540855 PMCID: PMC5298895 DOI: 10.1016/j.molcel.2016.06.038
Source DB: PubMed Journal: Mol Cell ISSN: 1097-2765 Impact factor: 17.970