Literature DB >> 27540855

Diverse Activities of Histone Acylations Connect Metabolism to Chromatin Function.

Arnob Dutta1, Susan M Abmayr2, Jerry L Workman3.   

Abstract

Modifications of histones play important roles in balancing transcriptional output. The discovery of acyl marks, besides histone acetylation, has added to the functional diversity of histone modifications. Since all modifications use metabolic intermediates as substrates for chromatin-modifying enzymes, the prevalent landscape of histone modifications in any cell type is a snapshot of its metabolic status. Here, we review some of the current findings of how differential use of histone acylations regulates gene expression as response to metabolic changes and differentiation programs.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  YEATS domain; bromodomain; histone acylation; metabolism

Mesh:

Substances:

Year:  2016        PMID: 27540855      PMCID: PMC5298895          DOI: 10.1016/j.molcel.2016.06.038

Source DB:  PubMed          Journal:  Mol Cell        ISSN: 1097-2765            Impact factor:   17.970


  68 in total

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