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Literature DB >> 2754013

Laboratory characterization of a swine influenza virus isolated from a fatal case of human influenza.

P A Rota¹, E P Rocha, M W Harmon, V S Hinshaw, M G Sheerar, Y Kawaoka, N J Cox, T F Smith.

Abstract

A swine influenza virus-like type A (H1N1) virus, designated A/Wisconsin/3523/88, was isolated in September 1988 from a Wisconsin woman who had died with primary viral pneumonia. Antigenic analyses with hemagglutinin-specific monoclonal antibodies and postinfection ferret serum indicated that the hemagglutinin of A/Wisconsin/3523/88 was antigenically closely related to viruses currently circulating in swine. Genetic analysis of the A/Wisconsin/3523/88 virus by RNA fingerprinting and partial RNA sequence analysis of seven of the eight segments indicated that the genome of the human isolate was similar to that of enzootic swine viruses. These laboratory data supported the epidemiologic findings that this human infection occurred by transmission of an enzootic swine influenza virus and that the virus showed no major genetic changes potentially related to increased pathogenesis.

Entities: Disease Species

Mesh：

Substances：

Year: 1989 PMID： 2754013 PMCID： PMC267575 DOI： 10.1128/jcm.27.6.1413-1416.1989

Source DB: PubMed Journal: J Clin Microbiol ISSN： 0095-1137 Impact factor: 5.948

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10. A comparison of the pathogenicity of avian and swine H5N1 influenza viruses in Indonesia.

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