Jennifer M Renaud1, Kathy Yip2, Jean Guimond3, Mikaël Trottier3, Philippe Pibarot3, Eric Turcotte4, Conor Maguire5, Lucille Lalonde5, Karen Gulenchyn6, Troy Farncombe6, Gerald Wisenberg7, Jonathan Moody8, Benjamin Lee8, Steven C Port9, Timothy G Turkington10, Rob S Beanlands1, Robert A deKemp11. 1. National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa Ontario, Canada. 2. KMH Cardiology & Diagnostic Centre, Mississauga Ontario, Canada. 3. Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Canada. 4. Centre Hospitalier Universitaire de Sherbrooke, Québec, Canada. 5. University of Alberta Hospital, Edmonton Alberta, Canada. 6. St. Joseph's Healthcare, Hamilton Ontario, Canada. 7. Lawson Health Research Institute, London Ontario, Canada. 8. INVIA Medical Imaging Solutions, Ann Arbor, Michigan. 9. Aurora Cardiovascular Services, Milwaukee, Wisconsin; and. 10. Duke University Medical Center, Durham, North Carolina. 11. National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa Ontario, Canada radekemp@ottawaheart.ca.
Abstract
Three-dimensional (3D) mode imaging is the current standard for PET/CT systems. Dynamic imaging for quantification of myocardial blood flow with short-lived tracers, such as 82Rb-chloride, requires accuracy to be maintained over a wide range of isotope activities and scanner counting rates. We proposed new performance standard measurements to characterize the dynamic range of PET systems for accurate quantitative imaging. METHODS: 82Rb or 13N-ammonia (1,100-3,000 MBq) was injected into the heart wall insert of an anthropomorphic torso phantom. A decaying isotope scan was obtained over 5 half-lives on 9 different 3D PET/CT systems and 1 3D/2-dimensional PET-only system. Dynamic images (28 × 15 s) were reconstructed using iterative algorithms with all corrections enabled. Dynamic range was defined as the maximum activity in the myocardial wall with less than 10% bias, from which corresponding dead-time, counting rates, and/or injected activity limits were established for each scanner. Scatter correction residual bias was estimated as the maximum cavity blood-to-myocardium activity ratio. Image quality was assessed via the coefficient of variation measuring nonuniformity of the left ventricular myocardium activity distribution. RESULTS: Maximum recommended injected activity/body weight, peak dead-time correction factor, counting rates, and residual scatter bias for accurate cardiac myocardial blood flow imaging were 3-14 MBq/kg, 1.5-4.0, 22-64 Mcps singles and 4-14 Mcps prompt coincidence counting rates, and 2%-10% on the investigated scanners. Nonuniformity of the myocardial activity distribution varied from 3% to 16%. CONCLUSION: Accurate dynamic imaging is possible on the 10 3D PET systems if the maximum injected MBq/kg values are respected to limit peak dead-time losses during the bolus first-pass transit.
Three-dimensional (3D) mode imaging is the current standard for PET/CT systems. Dynamic imaging for quantification of myocardial blood flow with short-lived tracers, such as 82Rb-chloride, requires accuracy to be maintained over a wide range of isotope activities and scanner counting rates. We proposed new performance standard measurements to characterize the dynamic range of PET systems for accurate quantitative imaging. METHODS:82Rb or 13N-ammonia (1,100-3,000 MBq) was injected into the heart wall insert of an anthropomorphic torso phantom. A decaying isotope scan was obtained over 5 half-lives on 9 different 3D PET/CT systems and 1 3D/2-dimensional PET-only system. Dynamic images (28 × 15 s) were reconstructed using iterative algorithms with all corrections enabled. Dynamic range was defined as the maximum activity in the myocardial wall with less than 10% bias, from which corresponding dead-time, counting rates, and/or injected activity limits were established for each scanner. Scatter correction residual bias was estimated as the maximum cavity blood-to-myocardium activity ratio. Image quality was assessed via the coefficient of variation measuring nonuniformity of the left ventricular myocardium activity distribution. RESULTS: Maximum recommended injected activity/body weight, peak dead-time correction factor, counting rates, and residual scatter bias for accurate cardiac myocardial blood flow imaging were 3-14 MBq/kg, 1.5-4.0, 22-64 Mcps singles and 4-14 Mcps prompt coincidence counting rates, and 2%-10% on the investigated scanners. Nonuniformity of the myocardial activity distribution varied from 3% to 16%. CONCLUSION: Accurate dynamic imaging is possible on the 10 3D PET systems if the maximum injected MBq/kg values are respected to limit peak dead-time losses during the bolus first-pass transit.
Authors: Jonathan B Moody; Keri M Hiller; Benjamin C Lee; Alexis Poitrasson-Rivière; James R Corbett; Richard L Weinberg; Venkatesh L Murthy; Edward P Ficaro Journal: J Nucl Cardiol Date: 2019-02-26 Impact factor: 5.952
Authors: Venkatesh L Murthy; Timothy M Bateman; Rob S Beanlands; Daniel S Berman; Salvador Borges-Neto; Panithaya Chareonthaitawee; Manuel D Cerqueira; Robert A deKemp; E Gordon DePuey; Vasken Dilsizian; Sharmila Dorbala; Edward P Ficaro; Ernest V Garcia; Henry Gewirtz; Gary V Heller; Howard C Lewin; Saurabh Malhotra; April Mann; Terrence D Ruddy; Thomas H Schindler; Ronald G Schwartz; Piotr J Slomka; Prem Soman; Marcelo F Di Carli; Andrew Einstein; Raymond Russell; James R Corbett Journal: J Nucl Cardiol Date: 2018-02 Impact factor: 5.952
Authors: Joris D van Dijk; Pieter L Jager; Jochen A C van Osch; Maryam Khodaverdi; Jorn A van Dalen Journal: J Nucl Cardiol Date: 2018-01-16 Impact factor: 5.952
Authors: Daniel Juneau; Kai Yi Wu; Nicole Kaps; Jason Yao; Jennifer M Renaud; Rob S B Beanlands; Terrence D Ruddy; Robert A deKemp Journal: J Nucl Cardiol Date: 2021-01-03 Impact factor: 5.952