Chengyuan Tang1, Liyu He1, Jing Liu1, Zheng Dong2. 1. Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, China. 2. Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, China; Department of Cellular Biology and Anatomy, Medical College of Georgia at Georgia Regents University and Charlie Norwood VA Medical Center, Augusta, Ga., USA.
Abstract
BACKGROUND: Mitochondria play fundamental roles in cellular metabolism, signaling, and viability. Disruption of mitochondria not only leads to dysfunction of the organelles but also activates mechanisms of cell injury and death, contributing to the pathogenesis of various diseases. SUMMARY: Removal of damaged mitochondria is therefore crucial for cellular homeostasis and survival. Mitophagy, the selective elimination of mitochondria via autophagy, is an important mechanism of mitochondrial quality control in physiological and pathological conditions. Defects in mitophagy have been implicated in a variety of human disorders, including both acute and chronic kidney diseases. However, the role and regulatory mechanisms of mitophagy in kidney cells and tissues remain largely unknown. KEY MESSAGE: This review provides updated information on mitophagy and suggests a potential role of mitophagy in renal pathophysiology.
BACKGROUND: Mitochondria play fundamental roles in cellular metabolism, signaling, and viability. Disruption of mitochondria not only leads to dysfunction of the organelles but also activates mechanisms of cell injury and death, contributing to the pathogenesis of various diseases. SUMMARY: Removal of damaged mitochondria is therefore crucial for cellular homeostasis and survival. Mitophagy, the selective elimination of mitochondria via autophagy, is an important mechanism of mitochondrial quality control in physiological and pathological conditions. Defects in mitophagy have been implicated in a variety of human disorders, including both acute and chronic kidney diseases. However, the role and regulatory mechanisms of mitophagy in kidney cells and tissues remain largely unknown. KEY MESSAGE: This review provides updated information on mitophagy and suggests a potential role of mitophagy in renal pathophysiology.
Authors: Sven Geisler; Kira M Holmström; Diana Skujat; Fabienne C Fiesel; Oliver C Rothfuss; Philipp J Kahle; Wolfdieter Springer Journal: Nat Cell Biol Date: 2010-01-24 Impact factor: 28.824
Authors: Samuel A Hasson; Lesley A Kane; Koji Yamano; Chiu-Hui Huang; Danielle A Sliter; Eugen Buehler; Chunxin Wang; Sabrina M Heman-Ackah; Tara Hessa; Rajarshi Guha; Scott E Martin; Richard J Youle Journal: Nature Date: 2013-11-24 Impact factor: 49.962
Authors: Xianghong Zhang; John E Griepentrog; Baobo Zou; Li Xu; Anthony R Cyr; Lauran M Chambers; Brian S Zuckerbraun; Sruti Shiva; Matthew R Rosengart Journal: Cell Calcium Date: 2020-09-05 Impact factor: 6.817
Authors: Hagir Suliman; Qing Ma; Zhiquan Zhang; Jiafa Ren; Benjamin T Morris; Steven D Crowley; Luis Ulloa; Jamie R Privratsky Journal: Front Physiol Date: 2021-07-01 Impact factor: 4.566