Cristina Valero1, Laura Pardo1, Montserrat López1, Jacinto García1, Mercedes Camacho2, Miquel Quer1, Xavier León1,3. 1. Otorhinolaryngology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain. 2. Laboratory of Angiology, Vascular Biology and Inflammation, Institute of Biomedical Research (IIB Sant Pau), Barcelona, Spain. 3. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain.
Abstract
BACKGROUND: The purpose of this study was to analyze the prognostic value of pretreatment count of peripheral neutrophils, lymphocytes, monocytes, and neutrophil-to-lymphocyte ratio (NLR) in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: Local, regional, and distant recurrence-free survival and disease-specific survival were analyzed according to the count of neutrophils, lymphocytes, monocytes, and NLR. RESULTS: We observed a decrease in disease-specific survival as the quartile category of neutrophils, monocytes, and NLR increased. In the case of lymphocytes, patients in the lower quartile had lower disease-specific survival. Considering the disease-specific survival as the dependent variable, a recursive partitioning analysis classified the patients according to the neutrophil and monocyte counts. CONCLUSION: High pretreatment count of peripheral neutrophils and/or monocytes was independently related with worse prognosis in patients with HNSCC. Classification based on pretreatment neutrophil and monocyte counts enabled the identification of different prognostic profiles.
BACKGROUND: The purpose of this study was to analyze the prognostic value of pretreatment count of peripheral neutrophils, lymphocytes, monocytes, and neutrophil-to-lymphocyte ratio (NLR) in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: Local, regional, and distant recurrence-free survival and disease-specific survival were analyzed according to the count of neutrophils, lymphocytes, monocytes, and NLR. RESULTS: We observed a decrease in disease-specific survival as the quartile category of neutrophils, monocytes, and NLR increased. In the case of lymphocytes, patients in the lower quartile had lower disease-specific survival. Considering the disease-specific survival as the dependent variable, a recursive partitioning analysis classified the patients according to the neutrophil and monocyte counts. CONCLUSION: High pretreatment count of peripheral neutrophils and/or monocytes was independently related with worse prognosis in patients with HNSCC. Classification based on pretreatment neutrophil and monocyte counts enabled the identification of different prognostic profiles.
Authors: Cristina Valero; Daniella K Zanoni; Marlena R McGill; Ian Ganly; Luc G T Morris; Miquel Quer; Jatin P Shah; Richard J Wong; Xavier León; Snehal G Patel Journal: Cancer Date: 2019-12-06 Impact factor: 6.860
Authors: Cristina Valero; Dauren Adilbay; Conall W R Fitzgerald; Avery Yuan; Ximena Mimica; Piyush Gupta; Richard J Wong; Jatin P Shah; Snehal G Patel; Marc A Cohen; Ian Ganly Journal: Oral Oncol Date: 2021-10-21 Impact factor: 5.337
Authors: Piergiorgio Gaudioso; Daniele Borsetto; Giancarlo Tirelli; Margherita Tofanelli; Fiordaliso Cragnolini; Anna Menegaldo; Cristoforo Fabbris; Gabriele Molteni; Daniele Marchioni; Piero Nicolai; Paolo Bossi; Andrea Ciorba; Stefano Pelucchi; Chiara Bianchini; Simone Mauramati; Marco Benazzo; Vittorio Giacomarra; Roberto Di Carlo; Mantegh Sethi; Jerry Polesel; Jonathan Fussey; Paolo Boscolo-Rizzo Journal: Support Care Cancer Date: 2021-01-29 Impact factor: 3.359