Yi Fang1,2, Yue Yang1,2, Min Chen1,2, Peijie He1,2, Lei Cheng1,2, Jian Chen3,4, Haitao Wu5,6. 1. Department of Otorhinolaryngology-Head and Neck Surgery (Shanghai Key Clinical Disciplines of Otorhinolaryngology), Eye, Ear, Nose and Throat Hospital of Fudan University, Fenyang Road Num 83, Xuhui District, Shanghai, 200031, China. 2. Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, 200031, China. 3. Department of Otorhinolaryngology-Head and Neck Surgery (Shanghai Key Clinical Disciplines of Otorhinolaryngology), Eye, Ear, Nose and Throat Hospital of Fudan University, Fenyang Road Num 83, Xuhui District, Shanghai, 200031, China. chenjent@qq.com. 4. Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, 200031, China. chenjent@qq.com. 5. Department of Otorhinolaryngology-Head and Neck Surgery (Shanghai Key Clinical Disciplines of Otorhinolaryngology), Eye, Ear, Nose and Throat Hospital of Fudan University, Fenyang Road Num 83, Xuhui District, Shanghai, 200031, China. eentwuhaitao@163.com. 6. Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, 200031, China. eentwuhaitao@163.com.
Abstract
OBJECTIVE: To evaluate the predictive value of preoperative peripheral inflammatory markers in patients with vocal fold leukoplakia. METHODS: A retrospective study was performed of the patients diagnosed with vocal fold leukoplakia and who accepted carbon dioxide (CO2) laser resection in our center in the last 10 years. We calculated the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR) after collecting and analyzing the clinical, histopathological and laboratory data. The potential relation between blood indexes and clinical events as recurrence or canceration was evaluated. RESULTS: A total of 589 patients were involved, including 300 cases without recurrence (group A), 198 with recurrence but not canceration (group B) and 91 transformed into squamous cancer (group C). Baseline analysis of NLR, PLR, and MLR showed no difference among the three groups before the first surgery. But all the indexes significantly elevated in groups B (P < 0.001, < 0.001, 0.023, respectively) and C (P = 0.009, 0.004, 0.007, respectively) in the last operation. The receiver-operating curve (ROC) analysis showed NLR as a potential marker of canceration of leukoplakia (AUC = 0.837) and the cutoff value was 2.505. When regrouping with pathological outcomes, severe dysplasia and squamous cell carcinoma (SCC) groups both revealed a higher level of NLR, PLR, and MLR comparing to the no dysplasia, mild dysplasia, and moderate dysplasia groups. NLR, PLR, and MLR in high-risk group (moderate, severe dysplasia and carcinoma) also elevated comparing to low-risk group (no dysplasia, mild dysplasia) (P = 0.039, 0.011, 0.007, respectively). CONCLUSIONS: The peripheral inflammatory markers NLR, PLR, and MLR are closely connected with the development of vocal fold leukoplakia. NLR may be a potential marker to predict the poor outcomes (recurrence or canceration) of patients in first surgery.
OBJECTIVE: To evaluate the predictive value of preoperative peripheral inflammatory markers in patients with vocal fold leukoplakia. METHODS: A retrospective study was performed of the patients diagnosed with vocal fold leukoplakia and who accepted carbon dioxide (CO2) laser resection in our center in the last 10 years. We calculated the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR) after collecting and analyzing the clinical, histopathological and laboratory data. The potential relation between blood indexes and clinical events as recurrence or canceration was evaluated. RESULTS: A total of 589 patients were involved, including 300 cases without recurrence (group A), 198 with recurrence but not canceration (group B) and 91 transformed into squamous cancer (group C). Baseline analysis of NLR, PLR, and MLR showed no difference among the three groups before the first surgery. But all the indexes significantly elevated in groups B (P < 0.001, < 0.001, 0.023, respectively) and C (P = 0.009, 0.004, 0.007, respectively) in the last operation. The receiver-operating curve (ROC) analysis showed NLR as a potential marker of canceration of leukoplakia (AUC = 0.837) and the cutoff value was 2.505. When regrouping with pathological outcomes, severe dysplasia and squamous cell carcinoma (SCC) groups both revealed a higher level of NLR, PLR, and MLR comparing to the no dysplasia, mild dysplasia, and moderate dysplasia groups. NLR, PLR, and MLR in high-risk group (moderate, severe dysplasia and carcinoma) also elevated comparing to low-risk group (no dysplasia, mild dysplasia) (P = 0.039, 0.011, 0.007, respectively). CONCLUSIONS: The peripheral inflammatory markers NLR, PLR, and MLR are closely connected with the development of vocal fold leukoplakia. NLR may be a potential marker to predict the poor outcomes (recurrence or canceration) of patients in first surgery.
Authors: Aswin Mangerich; Charles G Knutson; Nicola M Parry; Sureshkumar Muthupalani; Wenjie Ye; Erin Prestwich; Liang Cui; Jose L McFaline; Melissa Mobley; Zhongming Ge; Koli Taghizadeh; John S Wishnok; Gerald N Wogan; James G Fox; Steven R Tannenbaum; Peter C Dedon Journal: Proc Natl Acad Sci U S A Date: 2012-06-11 Impact factor: 11.205
Authors: Mati Mann; Arnav Mehta; Carl G de Boer; Monika S Kowalczyk; Kevin Lee; Pearce Haldeman; Noga Rogel; Abigail R Knecht; Daneyal Farouq; Aviv Regev; David Baltimore Journal: Cell Rep Date: 2018-12-11 Impact factor: 9.423
Authors: Marco de Vincentiis; Armando De Virgilio; Francesco Bussu; Roberto Gallus; Andrea Gallo; Giovanni Bastanza; Claudio Parrilla; Antonio Greco; Jacopo Galli; Rosaria Turchetta; Giovanni Almadori; Giulio Pagliuca; Vincenzo Valentini; Gaetano Paludetti Journal: Head Neck Date: 2014-04-17 Impact factor: 3.147
Authors: Ruth A Franklin; Will Liao; Abira Sarkar; Myoungjoo V Kim; Michael R Bivona; Kang Liu; Eric G Pamer; Ming O Li Journal: Science Date: 2014-05-08 Impact factor: 47.728
Authors: L Staníková; J Šatanková; H Kučová; R Walderová; K Zeleník; Pavel Komínek Journal: Eur Arch Otorhinolaryngol Date: 2016-08-11 Impact factor: 2.503
Authors: Jian Zhou; Duo Zhang; Bin Chen; Qing Li; Lin Zhou; Fei Liu; Kuang-Yen Chou; Lei Tao; Li-Ming Lu Journal: Oncol Lett Date: 2014-02-26 Impact factor: 2.967
Authors: C P Campello; M F B Lima-Silva; E L S de Lima; G R S Nunes; H A M Silva; E Dellalibera; L R P B de Britto; C A A Lemos; M T C Muniz Journal: Braz J Med Biol Res Date: 2022-03-11 Impact factor: 2.590