Kirsten Bibbins-Domingo1, David C Grossman2, Susan J Curry3, Karina W Davidson4, John W Epling5, Francisco A R García6, Matthew W Gillman7, Alex R Kemper8, Alex H Krist9, Ann E Kurth10, C Seth Landefeld11, Michael LeFevre12, Carol M Mangione13, Douglas K Owens14, William R Phillips15, Maureen G Phipps16, Michael P Pignone17, Albert L Siu18. 1. University of California, San Francisco. 2. Group Health Research Institute, Seattle, Washington. 3. University of Iowa, Iowa City. 4. Columbia University, New York, New York. 5. State University of New York Upstate Medical University, Syracuse. 6. Pima County Department of Health, Tucson, Arizona. 7. Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts. 8. Duke University, Durham, North Carolina. 9. Fairfax Family Practice Residency, Fairfax, Virginia10Virginia Commonwealth University, Richmond. 10. Yale University, New Haven, Connecticut. 11. University of Alabama at Birmingham. 12. University of Missouri, Columbia. 13. University of California, Los Angeles. 14. Veterans Affairs Palo Alto Health Care System, Palo Alto, California16Stanford University, Stanford, California. 15. University of Washington, Seattle. 16. Brown University, Providence, Rhode Island. 17. University of Texas at Austin. 18. Mount Sinai School of Medicine, New York, New York21James J. Peters Veterans Affairs Medical Center, Bronx, New York.
Abstract
IMPORTANCE: Elevations in levels of total, low-density lipoprotein, and non-high-density lipoprotein cholesterol; lower levels of high-density lipoprotein cholesterol; and, to a lesser extent, elevated triglyceride levels are associated with risk of cardiovascular disease in adults. OBJECTIVE: To update the 2007 US Preventive Services Task Force (USPSTF) recommendation on screening for lipid disorders in children, adolescents, and young adults. EVIDENCE REVIEW: The USPSTF reviewed the evidence on screening for lipid disorders in children and adolescents 20 years or younger--1 review focused on screening for heterozygous familial hypercholesterolemia, and 1 review focused on screening for multifactorial dyslipidemia. FINDINGS: Evidence on the quantitative difference in diagnostic yield between universal and selective screening approaches, the effectiveness and harms of long-term treatment and the harms of screening, and the association between changes in intermediate outcomes and improvements in adult cardiovascular health outcomes are limited. Therefore, the USPSTF concludes that the balance of benefits and harms cannot be determined. CONCLUSIONS AND RECOMMENDATION: The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for lipid disorders in children and adolescents 20 years or younger. (I statement).
IMPORTANCE: Elevations in levels of total, low-density lipoprotein, and non-high-density lipoprotein cholesterol; lower levels of high-density lipoprotein cholesterol; and, to a lesser extent, elevated triglyceride levels are associated with risk of cardiovascular disease in adults. OBJECTIVE: To update the 2007 US Preventive Services Task Force (USPSTF) recommendation on screening for lipid disorders in children, adolescents, and young adults. EVIDENCE REVIEW: The USPSTF reviewed the evidence on screening for lipid disorders in children and adolescents 20 years or younger--1 review focused on screening for heterozygous familial hypercholesterolemia, and 1 review focused on screening for multifactorial dyslipidemia. FINDINGS: Evidence on the quantitative difference in diagnostic yield between universal and selective screening approaches, the effectiveness and harms of long-term treatment and the harms of screening, and the association between changes in intermediate outcomes and improvements in adult cardiovascular health outcomes are limited. Therefore, the USPSTF concludes that the balance of benefits and harms cannot be determined. CONCLUSIONS AND RECOMMENDATION: The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for lipid disorders in children and adolescents 20 years or younger. (I statement).
Authors: Kathryn Foti; Randi E Foraker; Pamela Martyn-Nemeth; Cheryl A M Anderson; Nancy R Cook; Alice H Lichtenstein; Sarah D de Ferranti; Deborah Rohm Young; Marie-France Hivert; Robert Ross; Prakash Deedwania; Laurie P Whitsel; Lawrence J Appel Journal: Circ Cardiovasc Qual Outcomes Date: 2020-09-28
Authors: Emily F Gregory; Jeffrey M Miller; Richard C Wasserman; Roopa Seshadri; Robert W Grundmeier; David M Rubin; Alexander G Fiks Journal: Circ Cardiovasc Qual Outcomes Date: 2020-07-17
Authors: Matthew K Armstrong; Brooklyn J Fraser; Olli Hartiala; Marie-Jeanne Buscot; Markus Juonala; Feitong Wu; Juha Koskinen; Nina Hutri-Kähönen; Mika Kähönen; Tomi P Laitinen; Terho Lehtimäki; Jorma S A Viikari; Olli T Raitakari; Costan G Magnussen Journal: JAMA Cardiol Date: 2021-06-01 Impact factor: 14.676