| Literature DB >> 27532476 |
Susan H Eshleman1, Sarah E Hudelson, Andrew D Redd, Ronald Swanstrom, San-San Ou, Xinyi Cindy Zhang, Li-Hua Ping, Estelle Piwowar-Manning, Stephen F Porcella, Matthew F Sievers, Craig A Martens, Daniel Bruno, Elena Dukhovlinova, Marybeth McCauley, Theresa Gamble, Jessica M Fogel, Devin Sabin, Thomas C Quinn, Laurence Gunde, Madalitso Maliwichi, Nehemiah Nhando, Victor Akelo, Sikhulile Moyo, Ravindre Panchia, Nagalingeswaran Kumarasamy, Nuntisa Chotirosniramit, Marineide Gonçalves de Melo, Jose Pilotto, Beatriz Grinsztejn, Kenneth Mayer, Ying Q Chen, James P Hughes, Myron S Cohen.
Abstract
HIV Prevention Trials Network 052 demonstrated that antiretroviral therapy (ART) prevents HIV transmission in serodiscordant couples. HIV from index-partner pairs was analyzed to determine the genetic linkage status of partner infections. Forty-six infections were classified as linked, indicating that the index was the likely source of the partner's infection. Lack of viral suppression and higher index viral load were associated with linked infection. Eight linked infections were diagnosed after the index started ART: 4 near the time of ART initiation and 4 after ART failure. Linked infections were not observed when the index participant was stably suppressed on ART.Entities:
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Year: 2017 PMID： 27532476 PMCID： PMC5140698 DOI： 10.1097/QAI.0000000000001158
Source DB: PubMed Journal: J Acquir Immune Defic Syndr ISSN： 1525-4135 Impact factor: 3.731