Literature DB >> 2753143

Conserved amino acids in F-helix of bacteriorhodopsin form part of a retinal binding pocket.

K J Rothschild1, M S Braiman, T Mogi, L J Stern, H G Khorana.   

Abstract

A 3-dimensional model for the retinal binding pocket in the light-driven proton pump, bacteriorhodopsin, is proposed on the basis of spectroscopic studies of bacteriorhodopsin mutants. In this model Trp-182, Pro-186 and Trp-189 surround the polyene chain while Tyr-185 is positioned close to the retinylidene Schiff base. This model is supported by sequence homologies in the F-helices of bacteriorhodopsin and the related retinal proteins, halorhodopsin and rhodopsins.

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Year:  1989        PMID： 2753143     DOI： 10.1016/0014-5793(89)80774-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  17 in total

Review 1.  FTIR difference spectroscopy of bacteriorhodopsin: toward a molecular model.

Authors:  K J Rothschild
Journal:  J Bioenerg Biomembr       Date:  1992-04       Impact factor: 2.945

2.  Uv-visible spectroscopy of bacteriorhodopsin mutants: substitution of Arg-82, Asp-85, Tyr-185, and Asp-212 results in abnormal light-dark adaptation.

Authors:  M Duñach; T Marti; H G Khorana; K J Rothschild
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

3.  The reaction of hydroxylamine with bacteriorhodopsin studied with mutants that have altered photocycles: selective reactivity of different photointermediates.

Authors:  S Subramaniam; T Marti; S J Rösselet; K J Rothschild; H G Khorana
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

4.  Protein dynamics in the bacteriorhodopsin photocycle: submillisecond Fourier transform infrared spectra of the L, M, and N photointermediates.

Authors:  M S Braiman; O Bousché; K J Rothschild
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

5.  Hydration dependence of active core fluctuations in bacteriorhodopsin.

Authors:  Kathleen Wood; Ursula Lehnert; Brigitte Kessler; Giuseppe Zaccai; Dieter Oesterhelt
Journal:  Biophys J       Date:  2008-03-13       Impact factor: 4.033

6.  Quantum efficiency of the photochemical cycle of bacteriorhodopsin.

Authors:  R Govindjee; S P Balashov; T G Ebrey
Journal:  Biophys J       Date:  1990-09       Impact factor: 4.033

7.  Peptide building blocks from bacteriorhodopsin: isolation and physicochemical characterization of two individual transmembrane segments.

Authors:  M Wuethrich; H Sigrist
Journal:  J Protein Chem       Date:  1990-04

8.  Protonation state of Asp (Glu)-85 regulates the purple-to-blue transition in bacteriorhodopsin mutants Arg-82----Ala and Asp-85----Glu: the blue form is inactive in proton translocation.

Authors:  S Subramaniam; T Marti; H G Khorana
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

9.  Fourier transform infrared evidence for proline structural changes during the bacteriorhodopsin photocycle.

Authors:  K J Rothschild; Y W He; D Gray; P D Roepe; S L Pelletier; R S Brown; J Herzfeld
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

10.  Dynamics of different functional parts of bacteriorhodopsin: H-2H labeling and neutron scattering.

Authors:  V Réat; H Patzelt; M Ferrand; C Pfister; D Oesterhelt; G Zaccai
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-28       Impact factor: 11.205
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