Imen Hadjkacem1, Héla Ayadi2, Mariem Turki2, Sourour Yaich3, Khaoula Khemekhem2, Adel Walha2, Leila Cherif2, Yousr Moalla2, Farhat Ghribi2. 1. University of Sfax, Hédi Chaker Hospital, Department of Child and Adolescent Psychiatry, Sfax, Tunisia. Electronic address: hadjkacemimen@yahoo.fr. 2. University of Sfax, Hédi Chaker Hospital, Department of Child and Adolescent Psychiatry, Sfax, Tunisia. 3. University of Sfax, Hédi Chaker Hospital, Department of Community Medecine and Epidemiology, Sfax, Tunisia.
Abstract
OBJECTIVE: To identify prenatal, perinatal and postnatal risk factors in children with autism spectrum disorder (ASD) by comparing them to their siblings without autistic disorders. METHOD: The present study is cross sectional and comparative. It was conducted over a period of three months (July-September 2014). It included 101 children: 50 ASD's children diagnosed according to DSM-5 criteria and 51 unaffected siblings. The severity of ASD was assessed by the CARS. RESULTS: Our study revealed a higher prevalence of prenatal, perinatal and postnatal factors in children with ASD in comparison with unaffected siblings. It showed also a significant association between perinatal and postnatal factors and ASD (respectively p=0.03 and p=0.042). In this group, perinatal factors were mainly as type of suffering acute fetal (26% of cases), long duration of delivery and prematurity (18% of cases for each factor), while postnatal factors were represented principally by respiratory infections (24%). As for parental factors, no correlation was found between advanced age of parents at the moment of the conception and ASD. Likewise, no correlation was observed between the severity of ASD and different factors. After logistic regression, the risk factors retained for autism in the final model were: male gender, prenatal urinary tract infection, acute fetal distress, difficult labor and respiratory infection. CONCLUSIONS: The present survey confirms the high prevalence of prenatal, perinatal and postnatal factors in children with ASD and suggests the intervention of some of these factors (acute fetal distress and difficult labor, among others), as determinant variables for the genesis of ASD.
OBJECTIVE: To identify prenatal, perinatal and postnatal risk factors in children with autism spectrum disorder (ASD) by comparing them to their siblings without autistic disorders. METHOD: The present study is cross sectional and comparative. It was conducted over a period of three months (July-September 2014). It included 101 children: 50 ASD's children diagnosed according to DSM-5 criteria and 51 unaffected siblings. The severity of ASD was assessed by the CARS. RESULTS: Our study revealed a higher prevalence of prenatal, perinatal and postnatal factors in children with ASD in comparison with unaffected siblings. It showed also a significant association between perinatal and postnatal factors and ASD (respectively p=0.03 and p=0.042). In this group, perinatal factors were mainly as type of suffering acute fetal (26% of cases), long duration of delivery and prematurity (18% of cases for each factor), while postnatal factors were represented principally by respiratory infections (24%). As for parental factors, no correlation was found between advanced age of parents at the moment of the conception and ASD. Likewise, no correlation was observed between the severity of ASD and different factors. After logistic regression, the risk factors retained for autism in the final model were: male gender, prenatal urinary tract infection, acute fetal distress, difficult labor and respiratory infection. CONCLUSIONS: The present survey confirms the high prevalence of prenatal, perinatal and postnatal factors in children with ASD and suggests the intervention of some of these factors (acute fetal distress and difficult labor, among others), as determinant variables for the genesis of ASD.
Authors: Yan Li; Galen Missig; Beate C Finger; Samantha M Landino; Abigail J Alexander; Emery L Mokler; James O Robbins; Yunona Manasian; Woori Kim; Kwang-Soo Kim; Christopher J McDougle; William A Carlezon; Vadim Y Bolshakov Journal: J Neurosci Date: 2018-02-28 Impact factor: 6.167
Authors: Sepideh Saroukhani; Maureen Samms-Vaughan; MinJae Lee; MacKinsey A Bach; Jan Bressler; Manouchehr Hessabi; Megan L Grove; Sydonnie Shakespeare-Pellington; Katherine A Loveland; Mohammad H Rahbar Journal: J Autism Dev Disord Date: 2020-09
Authors: Fernanda Alves Maia; Liliane Marta Mendes Oliveira; Maria Tereza Carvalho Almeida; Maria Rachel Alves; Vanessa Souza de Araújo Saeger; Victor Bruno da Silva; Victória Spínola Duarte de Oliveira; Hercílio Martelli Junior; Maria Fernanda Santos Figueiredo Brito; Marise Fagundes da Silveira Journal: Rev Paul Pediatr Date: 2019-07-18
Authors: Norrara Scarlytt de Oliveira Holanda; Lidiane Delgado Oliveira da Costa; Sabrinne Suelen Santos Sampaio; Gentil Gomes da Fonseca Filho; Ruth Batista Bezerra; Ingrid Guerra Azevedo; Silvana Alves Pereira Journal: Int J Environ Res Public Health Date: 2020-10-21 Impact factor: 3.390