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Literature DB >> 30338150

Optofluidic detection of Zika nucleic acid and protein biomarkers using multimode interference multiplexing.

Alexandra Stambaugh¹, Joshua W Parks¹, Matthew A Stott², Gopikrishnan G Meena¹, Aaron R Hawkins², Holger Schmidt¹.

Abstract

The recent massive Zika virus (ZIKV) outbreak illustrates the need for rapid and specific diagnostic techniques. Detecting ZIKV in biological samples poses unique problems: antibody detection of ZIKV is insufficient due to cross-reactivity of Zika antibodies with other flaviviruses, and nucleic acid and protein biomarkers for ZIKV are detectable at different stages of infection. Here, we describe a new optofluidic approach for the parallel detection of different molecular biomarkers using multimode interference (MMI) waveguides. We report differentiated, multiplex detection of both ZIKV biomarker types using multi-spot excitation at two visible wavelengths with over 98% fidelity by combining several analysis techniques.

Entities: Chemical Disease Species

Keywords: (130.3120) Integrated optics devices; (170.0170) Medical optics and biotechnology; (170.1610) Clinical applications; (230.7390) Waveguides, planar

Year: 2018 PMID： 30338150 PMCID： PMC6191625 DOI： 10.1364/BOE.9.003725

Source DB: PubMed Journal: Biomed Opt Express ISSN： 2156-7085 Impact factor: 3.732

24 in total

1. Microcephaly in Brazil: how to interpret reported numbers?

Authors: Cesar Gomes Victora; Lavinia Schuler-Faccini; Alicia Matijasevich; Erlane Ribeiro; André Pessoa; Fernando Celso Barros
Journal: Lancet Date: 2016-02-07 Impact factor: 79.321

2. Planar optofluidic chip for single particle detection, manipulation, and analysis.

Authors: Dongliang Yin; Evan J Lunt; Mikhail I Rudenko; David W Deamer; Aaron R Hawkins; Holger Schmidt
Journal: Lab Chip Date: 2007-06-27 Impact factor: 6.799

3. Phylogeny of the genus Flavivirus.

Authors: G Kuno; G J Chang; K R Tsuchiya; N Karabatsos; C B Cropp
Journal: J Virol Date: 1998-01 Impact factor: 5.103

4. Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of Ebola virus.

Authors: K Du; H Cai; M Park; T A Wall; M A Stott; K J Alfson; A Griffiths; R Carrion; J L Patterson; A R Hawkins; H Schmidt; R A Mathies
Journal: Biosens Bioelectron Date: 2017-01-03 Impact factor: 10.618

5. Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection.

Authors: Karin Stettler; Martina Beltramello; Diego A Espinosa; Victoria Graham; Antonino Cassotta; Siro Bianchi; Fabrizia Vanzetta; Andrea Minola; Stefano Jaconi; Federico Mele; Mathilde Foglierini; Mattia Pedotti; Luca Simonelli; Stuart Dowall; Barry Atkinson; Elena Percivalle; Cameron P Simmons; Luca Varani; Johannes Blum; Fausto Baldanti; Elisabetta Cameroni; Roger Hewson; Eva Harris; Antonio Lanzavecchia; Federica Sallusto; Davide Corti
Journal: Science Date: 2016-07-14 Impact factor: 47.728

6. Optofluidic bioanalysis: fundamentals and applications.

Authors: Damla Ozcelik; Hong Cai; Kaelyn D Leake; Aaron R Hawkins; Holger Schmidt
Journal: Nanophotonics Date: 2017-03-16 Impact factor: 8.449

7. Hybrid optofluidic integration.

Authors: Joshua W Parks; Hong Cai; Lynnell Zempoaltecatl; Thomas D Yuzvinsky; Kaelyn Leake; Aaron R Hawkins; Holger Schmidt
Journal: Lab Chip Date: 2013-08-23 Impact factor: 6.799

8. Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013.

Authors: E Oehler; L Watrin; P Larre; I Leparc-Goffart; S Lastere; F Valour; L Baudouin; Hp Mallet; D Musso; F Ghawche
Journal: Euro Surveill Date: 2014-03-06

9. Scalable Spatial-Spectral Multiplexing of Single-Virus Detection Using Multimode Interference Waveguides.

Authors: Damla Ozcelik; Aadhar Jain; Alexandra Stambaugh; Matthew A Stott; Joshua W Parks; Aaron Hawkins; Holger Schmidt
Journal: Sci Rep Date: 2017-09-22 Impact factor: 4.379

10. Correlated electrical and optical analysis of single nanoparticles and biomolecules on a nanopore-gated optofluidic chip.

Authors: Shuo Liu; Yue Zhao; Joshua W Parks; David W Deamer; Aaron R Hawkins; Holger Schmidt
Journal: Nano Lett Date: 2014-07-11 Impact factor: 11.189

12 in total

Optofluidic detection of Zika nucleic acid and protein biomarkers using multimode interference multiplexing.

1. Microcephaly in Brazil: how to interpret reported numbers?

2. Planar optofluidic chip for single particle detection, manipulation, and analysis.

3. Phylogeny of the genus Flavivirus.

4. Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of Ebola virus.

5. Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection.

6. Optofluidic bioanalysis: fundamentals and applications.

7. Hybrid optofluidic integration.

8. Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013.

9. Scalable Spatial-Spectral Multiplexing of Single-Virus Detection Using Multimode Interference Waveguides.

10. Correlated electrical and optical analysis of single nanoparticles and biomolecules on a nanopore-gated optofluidic chip.

1. Ultrasensitive detection of SARS-CoV-2 RNA and antigen using single-molecule optofluidic chip.

2. Free-Space Excitation of Optofluidic Devices for Pattern-Based Single Particle Detection.

3. 3× multiplexed detection of antibiotic resistant plasmids with single molecule sensitivity.

4. Greatly Enhanced Single Particle Fluorescence Detection Using High Refractive Index Liquid-Core Waveguides.

5. On-Chip Optical Detection of Viruses: A Review.

6. FPGA Integrated Optofluidic Biosensor for Real-Time Single Biomarker Analysis.

7. Fast custom wavelet analysis technique for single molecule detection and identification.

Review 8. Smartphone-Based Multiplexed Biosensing Tools for Health Monitoring.

9. Optofluidic Amplification-free Multiplex Detection of Viral Hemorrhagic Fevers.

10. 3D Hydrodynamic Focusing in Microscale Optofluidic Channels Formed with a Single Sacrificial Layer.