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Literature DB >> 27523778

Chagas Disease: A Solvable Problem, Ignored.

Abstract

Chagas disease is the highest impact parasitic disease in the Americas, yet remains virtually unknown and untreated, despite the fact that the infection is curable and the global problem of Chagas disease is manageable. The causes of this situation and how it can be changed are the focus of this communication.

Entities: Chemical Disease Species

Keywords: Chagas disease; Trypanosoma cruzi.; drug discovery; neglected diseases

Mesh：

Substances：
Trypanocidal Agents

Year: 2016 PMID： 27523778 PMCID： PMC5748248 DOI： 10.1016/j.molmed.2016.07.008

Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951

16 in total

1. Sustainability of vector control strategies in the Gran Chaco Region: current challenges and possible approaches.

Authors: Ricardo E Gürtler
Journal: Mem Inst Oswaldo Cruz Date: 2009-07 Impact factor: 2.743

Review 2. Potential new clinical therapies for Chagas disease.

Authors: Juan M Bustamante; Rick L Tarleton
Journal: Expert Rev Clin Pharmacol Date: 2014-04-09 Impact factor: 5.045

3. The Trypanosoma cruzi flagellum is discarded via asymmetric cell division following invasion and provides early targets for protective CD8⁺ T cells.

Authors: Samarchith P Kurup; Rick L Tarleton
Journal: Cell Host Microbe Date: 2014-10-08 Impact factor: 21.023

Review 4. Chagas disease (American trypanosomiasis) in Mexico: an update.

Authors: Alejandro Carabarin-Lima; María Cristina González-Vázquez; Olivia Rodríguez-Morales; Lidia Baylón-Pacheco; José Luis Rosales-Encina; Pedro Antonio Reyes-López; Minerva Arce-Fonseca
Journal: Acta Trop Date: 2013-04-30 Impact factor: 3.112

5. Towards a paradigm shift in the treatment of chronic Chagas disease.

Authors: R Viotti; B Alarcón de Noya; T Araujo-Jorge; M J Grijalva; F Guhl; M C López; J M Ramsey; I Ribeiro; A G Schijman; S Sosa-Estani; F Torrico; J Gascon
Journal: Antimicrob Agents Chemother Date: 2013-11-18 Impact factor: 5.191

Review 6. A systematic review of high quality diagnostic tests for Chagas disease.

Authors: Anna M Afonso; Mark H Ebell; Rick L Tarleton
Journal: PLoS Negl Trop Dis Date: 2012-11-08

7. Is Chagas disease really the "new HIV/AIDS of the Americas"?

Authors: Rick L Tarleton; James W Curran
Journal: PLoS Negl Trop Dis Date: 2012-10-25

8. Reaching for the Holy Grail: insights from infection/cure models on the prospects for vaccines for Trypanosoma cruzi infection.

Authors: Juan Bustamante; Rick Tarleton
Journal: Mem Inst Oswaldo Cruz Date: 2015-04-28 Impact factor: 2.743

9. Chagas disease and the london declaration on neglected tropical diseases.

Authors: Rick L Tarleton; Ricardo E Gürtler; Julio A Urbina; Janine Ramsey; Rodolfo Viotti
Journal: PLoS Negl Trop Dis Date: 2014-10-09

10. The challenges of Chagas Disease-- grim outlook or glimmer of hope.

Authors: Rick L Tarleton; Richard Reithinger; Julio A Urbina; Uriel Kitron; Ricardo E Gürtler
Journal: PLoS Med Date: 2007-12 Impact factor: 11.069

10 in total

1. Trypanosoma cruzi 13C-labeled O-Glycan standards for mass spectrometry.

Authors: M Osman Sheikh; Elisabet Gas-Pascual; John N Glushka; Juan M Bustamante; Lance Wells; Christopher M West
Journal: Glycobiology Date: 2019-04-01 Impact factor: 4.313

2. Serological and molecular inquiry of Chagas disease in an Afro-descendant settlement in Mato Grosso do Sul State, Brazil.

Authors: Mariana Furquim da Silva Martins; Mariane Barroso Pereira; Juliana de Jesus Guimarães Ferreira; Adriana de Oliveira França; Marlon Cézar Cominetti; Eduardo de Castro Ferreira; Maria Elizabeth Moraes Cavalheiros Dorval; Cláudio Lúcio Rossi; Sílvia de Barros Mazon; Eros Antonio de Almeida; Sandra Cecília Botelho Costa; Gláucia Elisete Barbosa Marcon
Journal: PLoS One Date: 2018-01-09 Impact factor: 3.240

Review 3. Computer-Aided Drug Design Using Sesquiterpene Lactones as Sources of New Structures with Potential Activity against Infectious Neglected Diseases.

Authors: Chonny Herrera Acevedo; Luciana Scotti; Mateus Feitosa Alves; Margareth De Fátima Formiga Melo Diniz; Marcus Tullius Scotti
Journal: Molecules Date: 2017-01-03 Impact factor: 4.411

4. Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates.

Authors: Angel M Padilla; Wei Wang; Robert T Jacobs; Rick L Tarleton; Tsutomu Akama; David S Carter; Eric Easom; Yvonne Freund; Jason S Halladay; Yang Liu; Sarah A Hamer; Carolyn L Hodo; Gregory K Wilkerson; Dylan Orr; Brooke White; Arlene George; Huifeng Shen; Yiru Jin; Michael Zhuo Wang; Susanna Tse
Journal: Nat Microbiol Date: 2022-09-05 Impact factor: 30.964

5. SARs for the Antiparasitic Plant Metabolite Pulchrol. 3. Combinations of New Substituents in A/B-Rings and A/C-Rings.

Authors: Paola Terrazas; Efrain Salamanca; Marcelo Dávila; Sophie Manner; Alberto Gimenez; Olov Sterner
Journal: Molecules Date: 2021-06-28 Impact factor: 4.411

Review 6. Discovery and Genetic Validation of Chemotherapeutic Targets for Chagas' Disease.

Authors: Juan Felipe Osorio-Méndez; Ana María Cevallos
Journal: Front Cell Infect Microbiol Date: 2019-01-07 Impact factor: 5.293

Review 7. Cardiac Chagas Disease: MMPs, TIMPs, Galectins, and TGF-β as Tissue Remodelling Players.

Authors: Arthur Wilson Florencio da Costa; Jose Rodrigues do Carmo Neto; Yarlla Loyane Lira Braga; Beatriz Aquino Silva; Amanda Borges Lamounier; Bárbara Oliveira Silva; Marlene Antônia Dos Reis; Flávia Aparecida de Oliveira; Mara Rúbia Nunes Celes; Juliana Reis Machado
Journal: Dis Markers Date: 2019-11-25 Impact factor: 3.434