| Literature DB >> 27520941 |
Wagner A V da Silva1, Daniele C Rodrigues1, Ramon G de Oliveira1, Rhuan K S Mendes1, Tayná R Olegário1, Juliana C Rocha2, Tatjana S L Keesen2, Claudio G Lima-Junior3, Mário L A A Vasconcellos4.
Abstract
It is reported here the synthesis of novel Homodimers 12-19 of Morita-Baylis-Hillman adducts (MBHA) from one-pot Morita-Baylis-Hillman Reaction (MBHR) between aromatic aldehydes as eletrophiles and ethylene glycol diacrylate as Michael acceptor (35-94% yields) using cheap and green conditions. The bioactivities were evaluated against promastigote form of Leishmania donovani. All homodimers showed to be more potent than corresponding monomers. It is worth highlighting that the halogenated homodimers 17 and 18 (0.50μM) is almost 400 times more active than the corresponding monomer 10 and 1.24 times more potent than the second-line drug amphotericin B (0.62μM). Moreover, the selectivity index to 18 is very high (SIrb>400) far better than amphotericin B (SIrb=18.73). This is the first report of twin drugs strategy applied on Morita-Baylis-Hillman adducts.Entities:
Keywords: Homodimers; Leishmania donovani; Morita–Baylis–Hillman adducts; Twin drugs
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Year: 2016 PMID： 27520941 DOI： 10.1016/j.bmcl.2016.07.022
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823