Literature DB >> 27519135

Leptin and Hormones: Energy Homeostasis.

Georgios A Triantafyllou1, Stavroula A Paschou1, Christos S Mantzoros2.   

Abstract

Leptin, a 167 amino acid adipokine, plays a major role in human energy homeostasis. Its actions are mediated through binding to leptin receptor and activating JAK-STAT3 signal transduction pathway. It is expressed mainly in adipocytes, and its circulating levels reflect the body's energy stores in adipose tissue. Recombinant methionyl human leptin has been FDA approved for patients with generalized non-HIV lipodystrophy and for compassionate use in subjects with congenital leptin deficiency. The purpose of this review is to outline the role of leptin in energy homeostasis, as well as its interaction with other hormones.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Energy homeostasis; Hormonal interactions; Leptin; Metabolism; Obesity

Mesh：

Substances：

Year:  2016        PMID： 27519135     DOI： 10.1016/j.ecl.2016.04.012

Source DB:  PubMed          Journal:  Endocrinol Metab Clin North Am        ISSN： 0889-8529            Impact factor:   4.741


  25 in total

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Authors:  Izael S Costa; Amanda F Medeiros; Fabiana M C Carvalho; Vanessa C O Lima; Raphael P Serquiz; Alexandre C Serquiz; Vivian N Silbiger; Raul H Bortolin; Bruna L L Maciel; Elizeu A Santos; Ana H A Morais
Journal:  Obes Facts       Date:  2018-12-11       Impact factor: 3.942

Review 2.  Phenotypic and Genetic Characteristics of Lipodystrophy: Pathophysiology, Metabolic Abnormalities, and Comorbidities.

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Journal:  Curr Diab Rep       Date:  2018-11-08       Impact factor: 4.810

3.  Impact of Intragastric Balloon Treatment on Adipokines, Cytokines, and Metabolic Profile in Obese Individuals.

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Journal:  Obes Surg       Date:  2019-08       Impact factor: 4.129

4.  Effect of barley supplementation on the fecal microbiota, caecal biochemistry, and key biomarkers of obesity and inflammation in obese db/db mice.

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Review 5.  Effects of maternal obesity on placental function and fetal development.

Authors:  Kristy R Howell; Theresa L Powell
Journal:  Reproduction       Date:  2016-11-18       Impact factor: 3.906

Review 6.  Early Pregnancy Biochemical Predictors of Gestational Diabetes Mellitus.

Authors:  Camille E Powe
Journal:  Curr Diab Rep       Date:  2017-02       Impact factor: 4.810

Review 7.  Treatment Options for Lipodystrophy in Children.

Authors:  Francesca Mainieri; Veronica Maria Tagi; Francesco Chiarelli
Journal:  Front Endocrinol (Lausanne)       Date:  2022-05-04       Impact factor: 6.055

Review 8.  Placental function in maternal obesity.

Authors:  Amy C Kelly; Theresa L Powell; Thomas Jansson
Journal:  Clin Sci (Lond)       Date:  2020-04-30       Impact factor: 6.124

9.  Effects of early-life exposure to Western diet and voluntary exercise on adult activity levels, exercise physiology, and associated traits in selectively bred High Runner mice.

Authors:  Marcell D Cadney; Layla Hiramatsu; Zoe Thompson; Meng Zhao; Jarren C Kay; Jennifer M Singleton; Ralph Lacerda de Albuquerque; Margaret P Schmill; Wendy Saltzman; Theodore Garland
Journal:  Physiol Behav       Date:  2021-03-16

10.  Association of ADIPOQ-rs2241766 and FTO-rs9939609 genetic variants with body mass index trajectory in women of reproductive age over 6 years of follow-up: the PREDI study.

Authors:  Caroline Kroll; Dayana Rodrigues Farias; Thaís Rangel Bousquet Carrilho; Gilberto Kac; Marco Fabio Mastroeni
Journal:  Eur J Clin Nutr       Date:  2021-04-13       Impact factor: 4.016
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