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Literature DB >> 27518561

Epigenetic Mechanisms of Longevity and Aging.

Payel Sen¹, Parisha P Shah¹, Raffaella Nativio¹, Shelley L Berger².

Abstract

Aging is an inevitable outcome of life, characterized by progressive decline in tissue and organ function and increased risk of mortality. Accumulating evidence links aging to genetic and epigenetic alterations. Given the reversible nature of epigenetic mechanisms, these pathways provide promising avenues for therapeutics against age-related decline and disease. In this review, we provide a comprehensive overview of epigenetic studies from invertebrate organisms, vertebrate models, tissues, and in vitro systems. We establish links between common operative aging pathways and hallmark chromatin signatures that can be used to identify "druggable" targets to counter human aging and age-related disease.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Histones

Year: 2016 PMID： 27518561 PMCID： PMC5821249 DOI： 10.1016/j.cell.2016.07.050

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

183 in total

1. Lamin a truncation in Hutchinson-Gilford progeria.

Authors: Annachiara De Sandre-Giovannoli; Rafaëlle Bernard; Pierre Cau; Claire Navarro; Jeanne Amiel; Irène Boccaccio; Stanislas Lyonnet; Colin L Stewart; Arnold Munnich; Martine Le Merrer; Nicolas Lévy
Journal: Science Date: 2003-04-17 Impact factor: 47.728

2. Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction.

Authors: Blanka Rogina; Stephen L Helfand; Stewart Frankel
Journal: Science Date: 2002-11-29 Impact factor: 47.728

3. N6-methyladenine DNA modification in Drosophila.

Authors: Guoqiang Zhang; Hua Huang; Di Liu; Ying Cheng; Xiaoling Liu; Wenxin Zhang; Ruichuan Yin; Dapeng Zhang; Peng Zhang; Jianzhao Liu; Chaoyi Li; Baodong Liu; Yuewan Luo; Yuanxiang Zhu; Ning Zhang; Shunmin He; Chuan He; Hailin Wang; Dahua Chen
Journal: Cell Date: 2015-04-30 Impact factor: 41.582

4. Expression of DNA methyltransferases is influenced by growth hormone in the long-living Ames dwarf mouse in vivo and in vitro.

Authors: Vanessa L Armstrong; Sharlene Rakoczy; Lalida Rojanathammanee; Holly M Brown-Borg
Journal: J Gerontol A Biol Sci Med Sci Date: 2013-11-07 Impact factor: 6.053

5. Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging.

Authors: Dale K Shumaker; Thomas Dechat; Alexander Kohlmaier; Stephen A Adam; Matthew R Bozovsky; Michael R Erdos; Maria Eriksson; Anne E Goldman; Satya Khuon; Francis S Collins; Thomas Jenuwein; Robert D Goldman
Journal: Proc Natl Acad Sci U S A Date: 2006-05-31 Impact factor: 11.205

6. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.

Authors: M Kaeberlein; M McVey; L Guarente
Journal: Genes Dev Date: 1999-10-01 Impact factor: 11.361

7. Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae.

Authors: S Kim; A Benguria; C Y Lai; S M Jazwinski
Journal: Mol Biol Cell Date: 1999-10 Impact factor: 4.138

8. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

Authors: Konrad T Howitz; Kevin J Bitterman; Haim Y Cohen; Dudley W Lamming; Siva Lavu; Jason G Wood; Robert E Zipkin; Phuong Chung; Anne Kisielewski; Li-Li Zhang; Brandy Scherer; David A Sinclair
Journal: Nature Date: 2003-08-24 Impact factor: 49.962

9. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.

Authors: Pankaj Kapahi; Brian M Zid; Tony Harper; Daniel Koslover; Viveca Sapin; Seymour Benzer
Journal: Curr Biol Date: 2004-05-25 Impact factor: 10.834

Review 10. Recent developments in yeast aging.

Authors: Matt Kaeberlein; Christopher R Burtner; Brian K Kennedy
Journal: PLoS Genet Date: 2007-05-25 Impact factor: 5.917

232 in total

Review 1. Epigenetic Regulation in Neurodegenerative Diseases.

Authors: Amit Berson; Raffaella Nativio; Shelley L Berger; Nancy M Bonini
Journal: Trends Neurosci Date: 2018-06-07 Impact factor: 13.837

Review 2. Alpha-1 Antitrypsin Deficiency and Accelerated Aging: A New Model for an Old Disease?

Authors: Diana Crossley; Robert Stockley; Elizabeth Sapey
Journal: Drugs Aging Date: 2019-09 Impact factor: 3.923

3. The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways.

Authors: Wonkyoung Cho; Xiongjie Jin; Junfeng Pang; Yan Wang; Nahid F Mivechi; Demetrius Moskophidis
Journal: Mol Cell Biol Date: 2019-04-16 Impact factor: 4.272

4. Calorie restriction breaks an epigenetic barrier to longevity.

Authors: Diego Molina-Serrano; Antonis Kirmizis
Journal: Cell Cycle Date: 2017-03-20 Impact factor: 4.534

Review 5. The role of epigenetics in renal ageing.

Authors: Paul G Shiels; Dagmara McGuinness; Maria Eriksson; Jeroen P Kooman; Peter Stenvinkel
Journal: Nat Rev Nephrol Date: 2017-06-19 Impact factor: 28.314

6. From HDACi to KDACi: we need to revisit non-epigenetic pathways affected by inhibiting lysine deacetylases in therapy.

Authors: Axel Imhof; Shahaf Peleg
Journal: EMBO Rep Date: 2016-10-24 Impact factor: 8.807