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Literature DB >> 27516729

Circulating Tumor Cells Versus Circulating Tumor DNA in Colorectal Cancer: Pros and Cons.

Carlyn Rose C Tan¹, Lanlan Zhou¹, Wafik S El-Deiry¹.

Abstract

Circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) are emerging noninvasive multifunctional biomarkers in liquid biopsy allowing for early diagnosis, accurate prognosis, therapeutic target selection, spatiotemporal monitoring of metastasis, as well as monitoring response and resistance to treatment. CTCs and ctDNA are released from different tumor types at different stages and contribute complementary information for clinical decision. Although big strides have been taken in technology development for detection, isolation and characterization of CTCs and sensitive and specific detection of ctDNA, CTC-, and ctDNA-based liquid biopsies may not be widely adopted for routine cancer patient care until the suitability, accuracy, and reliability of these tests are validated and more standardized protocols are corroborated in large, independent, prospectively designed trials. This review covers CTC- and ctDNA-related technologies and their application in colorectal cancer. The promise of CTC-and ctDNA-based liquid biopsies is envisioned.

Entities: Chemical Disease Gene Species

Keywords: CTC enrichment; Circulatingtumor DNA (ctDNA); Circulatingtumorcells(CTCs); Colorectal cancer (CRC); Liquid biopsy; Negative selection; Positive selection; Precision medicine; Resistance mechanism; Tumor heterogeneity

Year: 2016 PMID： 27516729 PMCID： PMC4976692 DOI： 10.1007/s11888-016-0320-y

Source DB: PubMed Journal: Curr Colorectal Cancer Rep ISSN： 1556-3790

87 in total

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21 in total

Review 1. PrediCTC, liquid biopsy in precision oncology: a technology transfer experience in the Spanish health system.

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Journal: Clin Transl Oncol Date: 2017-10-20 Impact factor: 3.405

Review 2. Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine.

Authors: Shuji Ogino; Jonathan A Nowak; Tsuyoshi Hamada; Amanda I Phipps; Ulrike Peters; Danny A Milner; Edward L Giovannucci; Reiko Nishihara; Marios Giannakis; Wendy S Garrett; Mingyang Song
Journal: Gut Date: 2018-02-06 Impact factor: 23.059

3. Association of clinical outcomes in metastatic breast cancer patients with circulating tumour cell and circulating cell-free DNA.

Authors: Zhong Ye; Chun Wang; Shaogui Wan; Zhaomei Mu; Zhenchao Zhang; Maysa M Abu-Khalaf; Frederick M Fellin; Daniel P Silver; Manish Neupane; Rebecca J Jaslow; Saveri Bhattacharya; Theodore N Tsangaris; Inna Chervoneva; Adam Berger; Laura Austin; Juan P Palazzo; Ronald E Myers; Neha Pancholy; Darayus Toorkey; Kaelan Yao; Max Krall; Xiuling Li; Xiaobing Chen; Xiuhong Fu; Jinliang Xing; Lifang Hou; Qiang Wei; Bingshan Li; Massimo Cristofanilli; Hushan Yang
Journal: Eur J Cancer Date: 2018-12-04 Impact factor: 9.162

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Authors: Junyun Wang; Shuang Chang; Guochao Li; Yingli Sun
Journal: Front Med Date: 2017-07-25 Impact factor: 4.592

Review 5. Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer.

Authors: Mark Lawler; Deborah Alsina; Richard A Adams; Annie S Anderson; Gina Brown; Nicola S Fearnhead; Stephen W Fenwick; Stephen P Halloran; Daniel Hochhauser; Mark A Hull; Viktor H Koelzer; Angus G K McNair; Kevin J Monahan; Inke Näthke; Christine Norton; Marco R Novelli; Robert J C Steele; Anne L Thomas; Lisa M Wilde; Richard H Wilson; Ian Tomlinson
Journal: Gut Date: 2018-01 Impact factor: 23.059

6. Predicting Outcome and Therapy Response in mCRC Patients Using an Indirect Method for CTCs Detection by a Multigene Expression Panel: A Multicentric Prospective Validation Study.

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Journal: Int J Mol Sci Date: 2017-06-13 Impact factor: 5.923